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NPY encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. Additionally we are shipping NPY Kits (63) and NPY Proteins (12) and many more products for this protein.
Showing 10 out of 140 products:
Alpaca (Vicugna pacos) Polyclonal NPY Primary Antibody for IEM, ICC - ABIN617905
Hogan, Terwilleger, Berman: Development of subpopulations of GABAergic neurons in cat visual cortical areas. in Neuroreport 1993
Show all 286 references for ABIN617905
Human Monoclonal NPY Primary Antibody for ELISA, WB - ABIN395848
Ide, Hara, Ohno, Tamano, Koseki, Naka, Maruyama, Kaneda, Yoshioka, Minami: Opposing roles of corticotropin-releasing factor and neuropeptide Y within the dorsolateral bed nucleus of the stria terminalis in the negative affective component of pain in rats. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2013
Human Polyclonal NPY Primary Antibody for IF (p), IHC (p) - ABIN724475
Duan, Hao, Fan, Wang, Liu, Hao, Xu, Liu, Zhang: The role of neuropeptide Y and aquaporin 4 in the pathogenesis of intestinal dysfunction caused by traumatic brain injury. in The Journal of surgical research 2013
Human Monoclonal NPY Primary Antibody for ELISA, WB - ABIN518402
Yang, Fung, Rothwell, Tianmei, Weickert: Increased interstitial white matter neuron density in the dorsolateral prefrontal cortex of people with schizophrenia. in Biological psychiatry 2010
Neuropeptide Y mRNA content decreased 6 h after a meal, but increased to prefeeding levels by 24 h.
NPY plays important roles in the pathogenesis and pathophysiology of pituitary adenomas, as shown in this clinical study.
NPY levels were higher in both obese and non-obese PCOS patients compared to healthy controls.
Authors observed that NPY levels were decreased in two (show ATXN3 Antibodies)Machado-Joseph disease patients' cerebella.
Suggest IL-4 (show IL4 Antibodies) as marker of allergic airway inflammation in asthma, and roles for adiponectin (show ADIPOQ Antibodies) and neuropeptide Y in neurohormonal signaling.
This study suggests that NPY rs16147 T and rs16139 C minor alleles are associated with increased risk, whereas the minor allele T of the rs5574 is associated with a reduced risk of obesity.
NPY expression is increased during atherogenesis and in particular in unstable plaques
The C-terminal alpha-helix of Neuropeptide Y, which is formed in a membrane environment in the absence of the receptor, is unwound starting at T(32) to provide optimal contacts in a binding pocket within the transmembrane bundle of the NPY-Y2 receptor (show NPY2R Antibodies).
Data suggest that nutritional status and up-regulation of NPY in cerebrospinal fluid are related to disease progression in adults with chronic kidney disease (CKD); up-regulation of serum NPY levels may predict risk of cardiovascular events in CKD.
in AN patients, the NPY system is not up-regulated by chronic undernutrition suggesting that this may play a role in the inability of anorectic women to adapt food intake to their energy demand.
The mean neuropeptide-Y level was 62.29 +/- 13.89 pg/mL in the breath-holding spells group and 58.24 +/- 12.30 pg/mL in the control group.
Neuropeptide Y (NPY) has been shown to be important in the modulation of anxiety.
Diet composition, not calorie intake, rapidly alters intrinsic excitability of hypothalamic AgRP (show AGRP Antibodies)/NPY neurons in mice.
NPY might be involved in the pathogenesis of METH (show MTRR Antibodies)-induced atherogenic effects through NPY Y1 receptor pathway in ApoE (show APOE Antibodies) knockout mice
NPY deficiency leads to reduced orexigenic stimulation and water diffusion parameters
NPY suppresses cAMP activation of brown-like adipocytes via down-regulation o brown fat-relevant gene expression and mitochondrial function.
Data show that chronic caloric restriction (CR) alters hypothalamic agouti-related protein (Agrp (show AGRP Antibodies)) and neuropeptide Y (Npy) gene expression similarly in Ghrelin (show GHRL Antibodies)+/+, Ghrelin (show GHRL Antibodies)-/-, ghrelin receptor Ghsr (show GHSR Antibodies)+/+, and Ghsr (show GHSR Antibodies)-/- mice.
These data demonstrate a clear role for neuropeptide Y as a negative regulator of monocyte recruitment into the central nervous system and provide a new mechanism for suppression of retrovirus-induced neurological disease.
NPY levels are decreased in Machado-Joseph disease (MJD (show ATXN3 Antibodies)) and that NPY overexpression is able to alleviate neuropathology and motor deficits in different MJD (show ATXN3 Antibodies) mouse models.
Prader-Willi critical region deletion in mice containing Snord116, and specifically in NPY neurons, recapitulates the short stature and low bone mass density and aspects of the hormonal imbalance of Prader-Willi syndrome individuals.
Npy gene expression in the arcuate nucleus is increased by intermittent fasting in diet-induced obese male mice.
Results show that the PP-fold is not important for recognition of peptide YY or neuropeptide Y at Y receptors.
NPY has a positive inotropic effect in isolated rat cardiac myocytes, which involves increase in Ca2 (show CA2 Antibodies)+ release after activation of Y1 NPY receptor
High dietary copper appears to increase feed intake and promote weight gain by enhancing NPY concentration and NPY mRNA expression level in the hypothalamus of pigs.
Neuropeptide Y was released from the lung tissue of brain-dead pigs, and its concentration was related to the extent of neurogenic pulmonary edema
Hormonal gene expression involved in residual feed intake in dairy cows may be related to the molecular regulation of the leptin (show LEP Antibodies)-NPY and insulin (show INS Antibodies) signaling pathways.
Data indicate that increased body weight gain during juvenile development accelerates sexual maturation in heifers, coincident with reciprocal changes in circulating concentrations of leptin (show LEP Antibodies) and hypothalamic neuropeptide Y (NPY) release.
There is a strong association between putative favorable allelic variants (SNP) of neuropeptide Y, leptin (show LEP Antibodies), and IGF-1 (show IGF1 Antibodies) genes, and residual feed intake, when animals were grazing on a high-quality, high-availability pasture.
The NPY SNP (NPY1) was associated with the prevalence of the animal being in calf 100 d after calving and 305-d milk yield in the first lactation.
NPY tended to increase serum growth hormone (show GH1 Antibodies), which appeared to be a consequence of increased pulse amplitude. Infusion of NPY also increased CSF (show CSF2 Antibodies) growth hormone-releasing hormone (show GHRH Antibodies).
Data show that PKA and PKC (show PKC Antibodies) pathways are involved in the differential regulation of production of the neuropeptides (Met)enkephalin, galanin (show GAL Antibodies), somatostatin (show SST Antibodies), NPY, and VIP (show Vip Antibodies).
The present investigation provides results of increased vasocontractile effect of NOR and decreased enhancing effect of NPY on NOR vasoconstriction in the rabbit facial artery after carotid occlusion that is related to altered endothelium function
NPY acts as an orexigenic factor in the zebrafish.
Neuropeptide Y/peptide YY receptor Y2 duplicate in zebrafish with unique introns displays distinct peptide binding properties.(
Developmental expression of zYb and zYc receptors suggests a role for neuropeptide Y (NPY) in organogenesis.
In this study described the the lateral line presence of NPY-like immunoreactivity (IR) in of the Antarctic nototheniod fish. Differences in size and cellular composition between the two neuromasts were presen NPY immunoreactivity.
A 2-day fast increased NPY gene expression in the supraoptic nucleus and paraventricular nucleus.
This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases.
, neuropeptide Ya
, prepro-neuropeptide Y
, pro-neuropeptide Y
, pro-neuropeptide Y preproprotein
, neuropeptide Yb
, pre-pro hormone
, preproneuropeptide Y, preproNPY