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Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Additionally we are shipping NPRL2 Proteins (4) and many more products for this protein.
Showing 10 out of 81 products:
Human Polyclonal NPRL2 Primary Antibody for ELISA, WB - ABIN408699
Ueda, Kawashima, Ohtani, Deng, Ravoori, Bankson, Gao, Girard, Minna, Roth, Kundra, Ji: The 3p21.3 tumor suppressor NPRL2 plays an important role in cisplatin-induced resistance in human non-small-cell lung cancer cells. in Cancer research 2006
Cow (Bovine) Polyclonal NPRL2 Primary Antibody for WB - ABIN2784227
Ewing, Chu, Elisma, Li, Taylor, Climie, McBroom-Cerajewski, Robinson, OConnor, Li, Taylor, Dharsee, Ho, Heilbut, Moore, Zhang, Ornatsky, Bukhman, Ethier, Sheng, Vasilescu, Abu-Farha, Lambert, Duewel et al.: Large-scale mapping of human protein-protein interactions by mass spectrometry. ... in Molecular systems biology 2007
This study demonstrated that NPRL2 mutation in familial focal epilepsies and focal cortical dysplasia.
Data confirmed NPRL2 was downregulated in gliomas. More importantly, NPRL2 was able to inhibit cell proliferation in vitro and repress tumorigenicity in vivo, suggesting its role as a tumor suppressor.
The positive regulation of mTORC1 activity by NPRL2 is mediated through NPRL2 interaction with Raptor (show RPTOR Antibodies).
NPRL2 mutations are significant cause of focal epilepsy.
NPRL2 acts as a functional tumor suppressor in colorectal cancer cell lines.
NPRL2 enhances sensitivity to oxaliplatin in colon cancer cells.
Decreased expression of NPRL2 is associated with renal cancer.
NPRL2 mRNA blood levels could be a potentially useful marker for the detection of early stage adenomas and colorectal cancers.
Results provide a set of genetic and biologic proofs that TUSC4 functions as a bona fide tumor suppressor by regulating the protein stability and function of BRCA1 in breast cancer.
NPRL2 expression is negatively related with the survival of osteosarcoma patients, indicating its value as a prognosis factor of osteosarcoma.
Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at the Tyr-9 Tyr-373 and Tyr-376 residues. May act as a tumor suppressor. Suppresses cell growth and enhanced sensitivity to various anticancer drugs.
, gene 21 protein
, nitrogen permase homolog
, nitrogen permease regulator 2-like protein
, tumor suppressor candidate 4
, G21 protein
, homologous to yeast nitrogen permease (candidate tumor suppressor)