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NCOR1 encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. Additionally we are shipping NCOR1 Kits (10) and NCOR1 Proteins (2) and many more products for this protein.
Showing 10 out of 93 products:
Human Monoclonal NCOR1 Primary Antibody for IHC (p), WB - ABIN1108391
Zhang, Yoon, Wong: JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2). in Molecular and cellular biology 2005
Show all 3 references for ABIN1108391
Human Monoclonal NCOR1 Primary Antibody for IHC, WB - ABIN2869350
Atsumi, Tomita, Kiyoi, Naoe: Histone deacetylase 3 (HDAC3) is recruited to target promoters by PML-RARalpha as a component of the N-CoR co-repressor complex to repress transcription in vivo. in Biochemical and biophysical research communications 2006
Show all 2 references for ABIN2869350
Human Polyclonal NCOR1 Primary Antibody for EIA, IHC (p) - ABIN356671
Tai, Geisterfer, Bell, Moniwa, Davie, Boucher, McBurney: CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins. in Biochemical and biophysical research communications 2003
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Human Polyclonal NCOR1 Primary Antibody for IF, IHC (p) - ABIN387976
Baek, Ohgi, Rose, Koo, Glass, Rosenfeld: Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein. in Cell 2002
Show all 2 references for ABIN387976
Dog (Canine) Polyclonal NCOR1 Primary Antibody for IHC, WB - ABIN2779671
Hörlein, Näär, Heinzel, Torchia, Gloss, Kurokawa, Ryan, Kamei, Söderström, Glass: Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. in Nature 1995
Ncor1 and Ncor2 (show NCOR2 Antibodies) play essential but distinct roles in zebrafish primitive myelopoiesis
demonstrate that the binding of HDAC3 (show HDAC3 Antibodies) to IR nGREs in vivo is mediated through interaction with SMRT (show NCOR2 Antibodies)/NCoR1
GR SUMOylation site is mandatory for the formation of a GR-small ubiquitin-related modifiers (SUMOs)-SMRT (show NCOR2 Antibodies)/NCoR1-HDAC3 (show HDAC3 Antibodies) repressing complex, which is indispensable for NF-kappaB (show NFKB1 Antibodies)/AP1 (show JUN Antibodies)-mediated GC-induced tethered indirect transrepression in vitro
dexamethasone, a powerful regulator of metabolism and of adipocyte differentiation, confers this change in NCoR mRNA splicing in cultured adipocytes.
Phosphorylation-mediated recruitment switch of NCoR1 between nuclear receptor subsets provides a mechanism by which corepressors can selectively modulate liver energy metabolism during the fasting-feeding transition
NCOR1 protein levels were significantly reduced.
corepressor specificity exists in vivo and that nuclear receptor corepressor1 is the principal regulator of thyroid hormone (show PTH Antibodies) action
NCOR1 interacts with Rev-Erbalpha (show NR1D1 Antibodies) to regulate circadian expression of Tshb (show TSHB Antibodies) mRNA independent of thyroid hormone (show PTH Antibodies).
these data indicate that interactions between NCoR1 and TR control a specific pathway involved in regulation of cholesterol metabolism and clearance.
Demonstrate that interaction with NCOR is essential for deacetylase-independent function of HDAC3 (show HDAC3 Antibodies) in liver.
Study shows that NCoR1 is a key target of proteolysis and physically interacts with the transcription factor CREB (show CREB1 Antibodies), the genome-wide map described here ties proteolysis in mammalian cells to active enhancers and to promoters of specific gene families.
Data suggest that complexes of HDAC3 (show HDAC3 Antibodies)-H1.3 with NCOR1 and NCOR2/SMRT (show NCOR2 Antibodies) accumulate on chromatin in synchronized HeLa cells in late G2 phase and mitosis; deacetylation activity of HDAC3 (show HDAC3 Antibodies) is activated via phosphorylation of Ser (show SIGLEC1 Antibodies)-424 by CK2 (show CSNK2A1 Antibodies) only in mitosis.
NCoR depletion enhances cancer cell invasion and increases tumor growth and metastatic potential.
loss of nuclear NCoR results in upregulation of a specific cancer-related genetic signature, and is significantly associated with malignant melanoma progression.
The co-localization of AML1 (show RUNX1 Antibodies)-ETO (show RUNX1T1 Antibodies) with the N-CoR co-repressor to be primarily on genomic regions distal to transcriptional start sites. (NcoR1)
Data suggest that direct interactions of HLCS (show HLCS Antibodies) (holocarboxylase synthetase) with NCOR1 (nuclear receptor corepressor 1) and HDAC1 (histone deacetylase 1 (show HDAC1 Antibodies)) contribute toward transcriptional repression of repeats, presumably increasing genome stability.
Low NCoR expression is associated with glioblastoma.
Site directed mutagenic analysis of N-CoR identified serine 1450 as the crucial residue whose phosphorylation by Akt (show AKT1 Antibodies) was essential for the misfolding and loss of N-CoR protein.
The aberrant cytoplasmic expression of NCoR1 in retinoblastoma appears to be associated with the proliferative and/or dedifferentiated properties of retinoblastoma.
Corepressor molecules NCoR and SMRT (show NCOR2 Antibodies) are present at 1,25(OH)2D3 activated gene enhancers
Data provide in vivo evidence for targeted recruitment of N-CoR/SMRT-TBLR1 (show TBL1XR1 Antibodies) complexes by unliganded thyroid hormone (show PTH Antibodies) receptors in transcriptional repression during vertebrate development
This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.
nuclear receptor corepressor 1
, nuclear receptor co-repressor 1
, retinoid X receptor interacting protein 13
, retinoid X receptor-interacting protein 13
, N-Cor/SMRT corepressor Rip13
, N-Cor/SMRT corepressor, Rip13
, thyroid hormone- and retinoic acid receptor-associated corepressor 1