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NOD2 is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). Additionally we are shipping NOD2 Kits (2) and and many more products for this protein.
Showing 10 out of 110 products:
Human Polyclonal NOD2 Primary Antibody for EIA, IHC (p) - ABIN500363
Inohara, Koseki, del Peso, Hu, Yee, Chen, Carrio, Merino, Liu, Ni, Núñez: Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-kappaB. in The Journal of biological chemistry 1999
Show all 4 references for ABIN500363
Human Polyclonal NOD2 Primary Antibody for EIA, IF - ABIN500365
Ogura, Inohara, Benito, Chen, Yamaoka, Nunez: Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. in The Journal of biological chemistry 2001
Show all 4 references for ABIN500365
Human Monoclonal NOD2 Primary Antibody for BCA - ABIN2666357
Miceli-Richard, Lesage, Rybojad, Prieur, Manouvrier-Hanu, Häfner, Chamaillard, Zouali, Thomas, Hugot: CARD15 mutations in Blau syndrome. in Nature genetics 2001
Show all 3 references for ABIN2666357
Human Polyclonal NOD2 Primary Antibody for IF, WB - ABIN318706
Inohara, Nuñez: NODs: intracellular proteins involved in inflammation and apoptosis. in Nature reviews. Immunology 2003
Show all 3 references for ABIN318706
Mouse (Murine) Monoclonal NOD2 Primary Antibody for WB - ABIN280900
Zanello, Goethel, Forster, Geddes, Philpott, Croitoru: Nod2 activates NF-kB in CD4+ T cells but its expression is dispensable for T cell-induced colitis. in PLoS ONE 2013
Human Polyclonal NOD2 Primary Antibody for ELISA, WB - ABIN185703
Keshav: Paneth cells: leukocyte-like mediators of innate immunity in the intestine. in Journal of leukocyte biology 2006
Human Monoclonal NOD2 Primary Antibody for ICC, IF - ABIN1721812
Cooney, Baker, Brain, Danis, Pichulik, Allan, Ferguson, Campbell, Jewell, Simmons: NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. in Nature medicine 2010
Significant associations were found between Crohn's disease (CD) and minor NOD2 variants, as well as TLR4 (show TLR4 Antibodies) 299Gly, TNF-alpha (show TNF Antibodies) G-308A, IL-6 (show IL6 Antibodies) G-174C and IL-1RN (show IL1RN Antibodies) VNTR A2 variants, while ulcerative colitis (UC) was associated only with IL-1RN (show IL1RN Antibodies) VNTR A2 variants.
CaSR (show CASR Antibodies)-induced constitutive macropinocytosis facilitates the sentinel function of macrophages, promoting the efficient delivery of ligands to cytosolic pattern-recognition receptors.
The INCA (show CARD17 Antibodies) trial (impact of NOD2 genotype-guided antibiotic prevention on survival in patients with liver cirrhosis and ascites): precision medicine for patients with liver cirrhosis and ascites
This is the first description of gonosomal NOD2 mosaicism as the cause of intrafamilial recurrence of Blau syndrome.
the rs2066847 variant of the NOD2/CARD15 gene is not associated with lung cancer risk in the Turkish population
data describe donor NOD2 SNP13 as a significant risk factor for the development of septic shock after allogeneic stem cell transplantation
NOD1 (show NOD1 Antibodies) and NOD2, two members of the NOD-like receptor family of pattern recognition receptors, are important mediators of ER-stress-induced inflammation in mouse and human cells
Blau syndrome has been strongly associated with mutations in the NOD2 gene. Read More: http://www.atsjournals.org/doi/full/10.1164/rccm.201507-1344LE#.VrgfNNL2byA
None of the NOD2/CARD15 variants was statistically associated to CRC (show CALR Antibodies) susceptibility in our Malaysian population.
data demonstrate that in Crohn's disease patients the IVS4+10 A>C NOD2 variant is strongly associated with the development of perianal fistulas
CD44 (show CD44 Antibodies), NOD2, and Fas (show FAS Antibodies) have distinct functions in regulating changes in trabecular and cortical bone indices during unloading.
The results indicate that Nod1 (show NOD1 Antibodies) cooperates with Nod2 or TLRs to produce cytokines in macrophages in response to M. tuberculosis infection.
Myocardial ischemia reperfusion injury markedly up-regulated NOD2 expression in heart tissue.
A novel crosstalk between TLR4 (show TLR4 Antibodies)- and NOD2-mediated signaling in the regulation of intestinal inflammation
Nod2-/- alveolar macrophages and blood neutrophils displayed a reduced capacity to internalize pneumococci in vitro.
NOD1 (show NOD1 Antibodies) and NOD2, play a collaborative role in T cell activation by alloantigen and that their blockade in vitro can inhibit T cell responses.
NOD2 and its downstream adaptor protein IPS-1 (show ISYNA1 Antibodies) have been found to be essential for LTB4 (show PTGR1 Antibodies)-mediated effects against IAV infection.
helminth infection protects mice deficient in the Crohn's disease susceptibility gene Nod2 from intestinal abnormalities by inhibiting colonization by an inflammatory Bacteroides species.
Macrophages from nod2 mutant R314Q mice and from patients from Blau syndrome showed reduced cytokine production and intracellular signaling of pathways normally activated by muramyl dipeptide
Data indicate six single-nucleotide polymorphisms (SNPs) in the caspase recruitment domain 15 protein (CARD15) gene associated with susceptibility to bovine tuberculosis (BTB) in Chinese Holstein cows.
Data indicate that the Nod2 signaling adaptor protein (NOD2) G-->A at position 1594 bp plays a critical role in increasing 305-day milk yields.
Genetic variation and putative regulatory regions in bovine CARD15.
A significant association was found between two polymorphisms of CARD15 and paratuberculosis status; cows with the heterozygous genotype were 3.35 times more likely to be infected than cows with the reference genotype.
This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome.
caspase recruitment domain 15 protein
, NLR family, CARD domain containing 2
, NOD-like receptor C2
, caspase recruitment domain family, member 15
, caspase recruitment domain protein 15
, caspase recruitment domain-containing protein 15
, inflammatory bowel disease protein 1
, nucleotide-binding oligomerization domain 2
, nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 2
, nucleotide-binding oligomerization domain-containing protein 2