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anti-Opsin 4 (OPN4) Antibodies

Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. Additionally we are shipping OPN4 Kits (4) and OPN4 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
OPN4 192223 Q8R456
OPN4 94233 Q9UHM6
OPN4 30044 Q9QXZ9
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Top anti-OPN4 Antibodies at

Showing 10 out of 20 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from COLO cells, using OPN4 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
Human Rabbit Un-conjugated ELISA, IF, WB Western Blot (WB) analysis of specific lysis using Melanopsin Polyclonal Antibody. 100 μL Log in to see 14 Days
Human Rabbit Un-conjugated WB Western blot analysis of Melanopsin expression in HEK293T (A) whole cell lysates. 200 μL Log in to see 9 Days
Human Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 6 to 11 Days
Human Rabbit Un-conjugated IF, WB 0.1 mg Log in to see 6 to 8 Days
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 8 to 10 Days
Human Rabbit Un-conjugated ICC, IHC (fro), IF, IHC, WB Figure 1 shows immunofluorescence staining of melanopsin in rat retinal ganglion cells using ABIN261558. Immunocytochemistry/Immunofluorescence: Melanopsin Antibody [ABIN2615580] - Staining in rat retinal ganglion cells. 0.1 mg Log in to see 5 to 7 Days
Human Rabbit Un-conjugated IHC, IHC (p) Immunohistochemistry: Melanopsin Antibody [NBP1-92105] - Staining of human placenta shows strong membrane positivity in trophoblastic cells. 0.1 mL Log in to see 16 to 18 Days
Human Rabbit Un-conjugated IHC, WB   100 μL Log in to see 7 to 8 Days
Mouse Rabbit Un-conjugated IHC, WB   100 μL Log in to see 7 to 8 Days

OPN4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Rat (Rattus)

Human ,

Mouse (Murine)

Top referenced anti-OPN4 Antibodies

  1. Human Polyclonal OPN4 Primary Antibody for IHC, WB - ABIN350459 : Dacey, Liao, Peterson, Robinson, Smith, Pokorny, Yau, Gamlin: Melanopsin-expressing ganglion cells in primate retina signal colour and irradiance and project to the LGN. in Nature 2005 (PubMed)
    Show all 5 references for ABIN350459

  2. Mouse (Murine) Polyclonal OPN4 Primary Antibody for IHC, WB - ABIN350682 : Hattar, Lucas, Mrosovsky, Thompson, Douglas, Hankins, Lem, Biel, Hofmann, Foster, Yau: Melanopsin and rod-cone photoreceptive systems account for all major accessory visual functions in mice. in Nature 2003 (PubMed)
    Show all 2 references for ABIN350682

  3. Human Polyclonal OPN4 Primary Antibody for ELISA, WB - ABIN1535846 : Melyan, Tarttelin, Bellingham, Lucas, Hankins: Addition of human melanopsin renders mammalian cells photoresponsive. in Nature 2005 (PubMed)

More Antibodies against OPN4 Interaction Partners

Zebrafish Opsin 4 (OPN4) interaction partners

  1. Melanopsin photostimulation triggers the phosphoinositide pathway through activation of a G-Protein, G11 (show STK19 Antibodies).

  2. The opn4a gene is expressed continuously from 1 to 3 dpf in the presumptive preoptic area, as defined by coexpression of the orthopedia homolog (otp (show OTP Antibodies)) gene.

  3. description of the discovery and functional characterisation of a new melanopsin gene in fish, bird, and amphibian genomes, demonstrating that vertebrates have evolved two quite separate melanopsins

Turkey Opsin 4 (OPN4) interaction partners

  1. Expressed locally in the premammillary nucleus of the hypothalamus in temperate zone birds, melanopsin is an important regulator of reproductive activity.

Human Opsin 4 (OPN4) interaction partners

  1. The light-induced FOS response in melanopsin expressing HEK (show EPHA3 Antibodies)-293 cells is correlated with melanopsin quantity and dependent on light duration and irradiance.

  2. By broadening the tuning of intrinsically photosensitive retinal ganglion cells, melanopsin tristability produces signal integration.

  3. The response of the human pupil to the separate stimulation of the cones and melanopsin at a range of temporal frequencies under photopic conditions, was measured.

  4. Studied OPN4*Ile394Thr gene polymorphism in association with sleep/wake timing.

  5. The results of this study showed that the post illumination pupil response varied on the basis of OPN4 I394T genotype among individuals with seasonal affective disorder.

  6. Studied the association between melanopsin gene polymorphism and pupillary light reflex under diverse photic conditions, including different intensities and wavelengths.

  7. A comparison of melanopsin with the mechanisms documented for vertebrate (bovine) and invertebrate (squid) visual photoreceptors shows that such a mechanism is not affected by the diversity of the three chromophore cavities.

  8. An action spectrum for the calcium response in cells expressing human melanopsin had the predicted form for an opsin (show RHO Antibodies) : vitamin A1 pigment and peaked at 479 nm. The G-protein selectivity and spectral sensitivity of human melanopsin is similar to that previously described for rodents.

  9. the results indicate that ectopic expression of human OPN4 in orexin (show OX Antibodies) neurons enables long-lasting activation of orexin (show OX Antibodies) neurons by blue light to control sleep/wakefulness of the mice.

  10. These results suggest that the P10L TT genotype of melanopsin interacts with daylength to predispose individuals to vary in sleep onset and chronotype as a function of daylength.

Mouse (Murine) Opsin 4 (OPN4) interaction partners

  1. Melanopsin overexpression in RGCs enhanced the amplitude and duration of their light response, and silencing them with Kir2.1 (show KCNJ2 Antibodies) significantly suppressed the increased mTOR (show FRAP1 Antibodies) signaling and axon regeneration that were induced by melanopsin

  2. mice null for melanopsin (Opn4-/-), lost significantly more weight than wild-type controls or mice lacking rod and cone photoreceptors.

  3. These results suggest GRK2 (show ADRBK1 Antibodies) contributes to melanopsin deactivation, but that other mechanisms account for most of modulation of melanopsin activity in ipRGCs.

  4. Using a combination of conventional knockout, chemogenetic, and receptor-silent substitution manipulations, we continued to show that, over higher irradiances, this increase in firing originates with inner-retinal melanopsin photoreception

  5. Opn4 mediates wavelength-specific, light-dependent vascular relaxation.

  6. Data indicate that retinal molecular circadian clock can be entrained by lighting cycles in vitro, but that rods, cones, and melanopsin (Opn4) are not required for this entrainment.

  7. critical phosphorylation sites on the carboxy tail of melanopsin

  8. Melanopsin Is required for normal Sensitivity and expression in alpha retinal ganglion cells.

  9. the role of melanopsin-expressing retinal ganglion cells in the glaucoma-induced depressive behavioral response pattern was investigated

  10. melanopsin is important for initiation and maintenance of light-induced sleep during the dark phase.

OPN4 Antigen Profile

Protein Summary

Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. This gene encodes a photoreceptive opsin protein that is expressed within the ganglion and amacrine cell layers of the retina. In mouse, retinal ganglion cell axons expressing this gene projected to the suprachiasmatic nucleus and other brain nuclei involved in circadian photoentrainment. In mouse, this protein is coupled to a transient receptor potential (TRP) ion channel through a G protein signaling pathway and produces a physiologic light response via membrane depolarization and increased intracellular calcium. The protein functions as a sensory photopigment and may also have photoisomerase activity. Experiments with knockout mice indicate that this gene attenuates, but does not abolish, photoentrainment. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with anti-Opsin 4 (OPN4) Antibodies

  • opsin 4.1 (opn4.1) antibody
  • opsin 4 (OPN4) antibody
  • opsin 4 (melanopsin) (opn4-A) antibody
  • opsin 4a (melanopsin) (opn4a) antibody
  • opsin 4 (Opn4) antibody
  • opsin 4 (melanopsin) (Opn4) antibody
  • 1110007J02Rik antibody
  • cOpn4L antibody
  • Gm533 antibody
  • melanopsin antibody
  • MOP antibody
  • opn4 antibody
  • OPN4-2 antibody
  • opn4-A antibody
  • opn4d antibody
  • opn4l antibody
  • opn4m2 antibody
  • Xmop antibody

Protein level used designations for anti-Opsin 4 (OPN4) Antibodies

melanopsin opn4m2 , melanopsin-like , opn4c , opsin 4 (melanopsin) , opsin 4, like , melanopsin , melanopsin 2 , opsin 4 like , putative Opsin 4 , opsin 4 , putative photopigment melanopsin , mammalian-like melanopsin , melanopsin opn4m1 , melanopsin-A , melanopsin-M , opn4m1 , opsin-4-A , opsin-4M , opsin-4

352918 Danio rerio
423609 Gallus gallus
515152 Bos taurus
611027 Canis lupus familiaris
735531 Pan troglodytes
100303707 Meleagris gallopavo
373689 Xenopus laevis
571624 Danio rerio
192223 Rattus norvegicus
94233 Homo sapiens
493921 Felis catus
30044 Mus musculus
Selected quality suppliers for anti-OPN4 (OPN4) Antibodies
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