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Origin Recognition Complex, Subunit 1-Like (Yeast) Proteins (ORC1L)

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Additionally we are shipping Origin Recognition Complex, Subunit 1-Like (Yeast) Antibodies (37) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ORC1L 4998 Q13415
ORC1L 18392 Q9Z1N2
Rat ORC1L ORC1L 313479 Q80Z32
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Top Origin Recognition Complex, Subunit 1-Like (Yeast) Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
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HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
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ORC1L Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for Origin Recognition Complex, Subunit 1-Like (Yeast) (ORC1L) Interaction Partners

Fruit Fly (Drosophila melanogaster) Origin Recognition Complex, Subunit 1-Like (Yeast) (ORC1L) interaction partners

  1. analyses show that orc1 allele newly identified is female sterile and possesses a unique feature of phenotypes that are distinct in different modes of DNA replication

  2. Orc1 functioned in silencing before duplication and Orc1 and Sir2 (show SIRT1 Proteins) may have an ancient history of cooperating to generate chromatin structures, with Sir2 (show SIRT1 Proteins) deacetylating histones and Orc1 binding to these deacetylated nucleosomes

Human Origin Recognition Complex, Subunit 1-Like (Yeast) (ORC1L) interaction partners

  1. Orc1 acts as a nucleating center for origin recognition complex assembly and then pre-replication complex assembly by binding to mitotic chromosomes, followed by gradual removal from chromatin during the G1 phase.

  2. ORC1 harbors a G-rich RNA/ssDNA-binding domain, which may be involved in the preferential binding to G-quadruplex-formable RNA/DNA by ORC. Structure modeling predicts the structural similarity between the G-rich RNA/ssDNA-binding domain of ORC1 and part of mammalian DNA methyltransferase 1 (show DNMT1 Proteins).

  3. ORC1 associated with transcription start sites of coding or noncoding RNAs. Transcription levels at the ORC1 sites directly correlated with replication timing.

  4. results identify the BAH (show ASPH Proteins) domain as a novel methyl-lysine-binding module, thereby establishing the first direct link between histone methylation and the metazoan DNA replication machinery, and defining a pivotal aetiological role for the canonical H4K20me2 mark, via ORC1, in primordial dwarfism

  5. Orc1 harbors a PACT (show RBBP6 Proteins) centrosome-targeting domain and a separate domain that differentially inhibits the protein kinase (show CDK7 Proteins) activities of Cyclin E (show CCNE1 Proteins)-CDK2 (show CDK2 Proteins) and Cyclin A (show CCNA2 Proteins)-CDK2 (show CDK2 Proteins)

  6. Data show that purified Epstein-Barr nuclear antigen 1 EBNA1 (show EBNA-1 Proteins) recruits purified Human Orc1 and Cdc6 (show CDC6 Proteins) onto replication origin oriP.

  7. A lethal phenotype was seen in four individuals with compound heterozygous ORC1 mutations

  8. As cells moved through the cell cycle, the local-ization of ORC1 shifted, suggesting changes in thelocalization of ORC-bound origin sequences.

  9. Mutations in ORC1, encoding a subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome. These mutations disrupt ORC1 functions including pre-replicative complex formation and origin activation.

  10. Data show that Orc1 specifically binds hypo-phosphorylated Rb and that this interaction is competitive with the binding of Rb to E2F1 (show E2F1 Proteins).

Mouse (Murine) Origin Recognition Complex, Subunit 1-Like (Yeast) (ORC1L) interaction partners

  1. mouse Orc1, Orc2, and Orc3 (show ORC3 Proteins) each exist in two alternative-splicing variants and naturally occurring Orc1B lacks a functional domain that is essential for nuclear translocation and proteasome-dependent degradation

Origin Recognition Complex, Subunit 1-Like (Yeast) (ORC1L) Protein Profile

Protein Summary

The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with ORC1L

  • Origin recognition complex subunit 1 (Orc1)
  • origin recognition complex subunit 1 (LOC100689425)
  • origin recognition complex, subunit 1 (ORC1)
  • origin recognition complex, subunit 1 (orc1)
  • origin recognition complex, subunit 1 (Orc1)
  • AA545195 protein
  • CG10667 protein
  • Dmel\\CG10667 protein
  • DmOrc1 protein
  • DmOrc1p protein
  • dORC1 protein
  • HSORC1 protein
  • MmORC1 protein
  • ORC protein
  • orc1 protein
  • Orc1l protein
  • PARC1 protein
  • rDmORC protein
  • xorc1 protein

Protein level used designations for ORC1L

CG10667-PA , Orc1-PA , origin recognition complex 1 , origin recognition complex subunit 1 , origin recognition complex, subunit 1 homolog , replication control protein 1 , origin recognition complex protein 1 , origin recognition complex, subunit 1-like

GENE ID SPECIES
35686 Drosophila melanogaster
100689425 Cricetulus griseus
4998 Homo sapiens
398063 Xenopus laevis
513523 Bos taurus
18392 Mus musculus
313479 Rattus norvegicus
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