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The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. Additionally we are shipping ODF1 Antibodies (8) and many more products for this protein.
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Study provides evidence that ODF1 down regulation is responsible for male infertility.
The expression of ODF1 was significantly decreased in the ejaculated spermatozoa of asthenozoospermic men.
Severe male subfertility provoked by haplo-deficiency of ODF1 is therefore most probably caused by impaired head-to-tail coupling that eventually might induce sperm decapitation on the specific conditions of in vivo fertilisation.
Heterozygous mutant male mice are fertile while sperm motility is reduced, but Odf1-deficient male mice are infertile due to the detachment of the sperm head.
Association of kinesin light chain with outer dense fibers in a microtubule-independent fashion.
The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. The human outer dense fibers contains at least 10 major proteins and this gene encodes the main protein.
outer dense fiber of sperm tails 1
, cancer/testis antigen 133
, outer dense fiber of sperm tails, 27-kD
, outer dense fiber protein 1
, outer dense fiber protein-1
, RTS 5/1
, Sperm outer dense fiber major protein 1
, outer dense fibers