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OSBPL11 encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Additionally we are shipping Oxysterol Binding Protein-Like 11 Antibodies (71) and many more products for this protein.
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ORP8 (show OSBPL8 Proteins) overexpression resulted in reduced expression of the aP2 (show GTF3A Proteins) mRNA, while down-regulation of adiponectin (show ADIPOQ Proteins) and aP2 (show GTF3A Proteins) was observed in ORP11 silenced cells. ORP8 (show OSBPL8 Proteins) overexpression or silencing of ORP11 markedly decreased cellular triglyceride storage.
The results identify ORP11 as an OSBP (show OSBP Proteins) homologue distributing at the Golgi-LE interface and define the ORP9 (show OSBPL9 Proteins)-ORP11 dimer as a functional unit that may act as an intracellular lipid sensor or transporter.
The OSBPL11 gene is involved in cholesterol and glucose metabolism in obese individuals.
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Like most members, the encoded protein contains an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain.
oxysterol binding protein-like 11
, oxysterol-binding protein-related protein 11
, oxysterol-binding protein-like protein 11
, osbpl11 protein
, oxysterol-binding protein-related protein 11-like
, OSBP-related protein 11