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PAX Interacting (With Transcription-Activation Domain) Protein 1 Proteins (PAXIP1)

PAXIP1 is a member of the paired box (PAX) gene family and encodes a nuclear protein with six BRCT (breast cancer carboxy-terminal) domains. Additionally we are shipping PAXIP1 Antibodies (21) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PAXIP1 22976 Q6ZW49
PAXIP1 55982 Q6NZQ4
PAXIP1 311944  
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Top PAXIP1 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$344.14
Details

PAXIP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

Rat (Rattus)

More Proteins for PAX Interacting (With Transcription-Activation Domain) Protein 1 (PAXIP1) Interaction Partners

Human PAX Interacting (With Transcription-Activation Domain) Protein 1 (PAXIP1) interaction partners

  1. PTIP promotes double-strand break repair through a direct role in homologous recombination.

  2. PPM1B (show PPM1B Proteins) can dephosphorylate the Pax2 (show PAX2 Proteins) activation domain and displace the adaptor protein PTIP, thus inhibiting H3K4 methylation and gene activation.

  3. uncovered a nuclease (show DCLRE1C Proteins), Artemis (show DCLRE1C Proteins), as a PTIP-binding protein

  4. PITX2 (show PITX2 Proteins) and PTIP co-occupy the promoter of the PITX2 (show PITX2 Proteins)'s transcriptional target.

  5. Polyglutamine expansion AR sequesters PTIP to attenuate DNA repair and increase genomic instability.

  6. a new clue to identify the role of PTIP in DNA damage pathway

  7. PTIP controls expression of P (show PPARG Proteins)PARgamma and C/ (show CEBPA Proteins)EBPalpha, the two principal adipogenic transcription factors, and is therefore required for adipogenesis.

  8. PTIP (PAXIP1) is a strong inhibitor of the trans-activation activities of Pax2A and Pax2B on the glucagon (show GCG Proteins) gene promoter and p8 binding to PTIP prevents inhibition of this promoter.

  9. identified tandem BRCT (BRCA1 carboxyl-terminal) domains in PTIP and in BRCA1 as phosphoserine- or phosphothreonine-specific binding modules that recognize substrates phosphorylated by the kinases ATM and ATR in response to gamma-irradiation

  10. hPTIP (PAXIP1) shows increased association with 53BP1 (show TP53BP1 Proteins) in response to ionizing radiation but not in response to other DNA-damaging agents.

Xenopus laevis PAX Interacting (With Transcription-Activation Domain) Protein 1 (PAXIP1) interaction partners

  1. Immunodepletion of PTIP/Swift from Xenopus extracts prevented efficient proliferating cell nuclear antigen (show PCNA Proteins) ubiquitination and polymerase eta (show POLH Proteins) recruitment to chromatin during replicative stress

Mouse (Murine) PAX Interacting (With Transcription-Activation Domain) Protein 1 (PAXIP1) interaction partners

  1. a PTIP-PA1 subcomplex functions independently from the MLL3/MLL4 complex to mediate transcription during CSR

  2. Study concludes that 53BP1 (show TP53BP1 Proteins) promotes productive class switch recombination and suppresses mutagenic DNA repair through distinct phosphodependent interactions with RIF1 and PTIP.

  3. Polyglutamine expansion AR sequesters PTIP to attenuate DNA repair and increase genomic instability.

  4. PAXIP1 controls distinct transcriptional programs during DP differentiation necessary for Tcra locus accessibility, licensing mature thymocytes for trafficking and natural killer T cell development.

  5. PTIP plays an important role in the DNA repair process associated with the development of mature spermatozoa.

  6. PTIP stabilizes the Pax5 (show PAX5 Proteins) DNA interactions that promote chromatin looping and regulate transcriptional responses needed for class switch recombination.

  7. Data show that loss of PTIP resulting in subtle changes in gene expression patterns and lower H3K4 methylation.

  8. PTIP accumulation at double stranded breaks contributes to class switch recombination and genome stability independently of Igh switch transcription

  9. PTIP is an essential element of the cell proliferation machinery, perhaps by functioning in the DNA repair pathways

  10. Pax (show PXN Proteins) transactivation domain-interacting protein is required for the urine concentration mechanism by modulating arginine vasopressin receptor 2 and AQP2 (show AQP2 Proteins) expression in the inner medulla.

PAXIP1 Protein Profile

Protein Summary

This gene is a member of the paired box (PAX) gene family and encodes a nuclear protein with six BRCT (breast cancer carboxy-terminal) domains. This protein plays a critical role in maintaining genome stability, condensation of chromatin and progression through mitosis.

Gene names and symbols associated with PAXIP1

  • PAX interacting (with transcription-activation domain) protein 1 (PAXIP1)
  • PAX interacting (with transcription-activation domain) protein 1 (paxip1)
  • pax interacting (with transcription-activation domain) protein 1 (paxip1)
  • PAX interacting (with transcription-activation domain) protein 1 (Paxip1)
  • cagf28 protein
  • cagf29 protein
  • D5Ertd149e protein
  • k14 protein
  • pacip1 protein
  • paxip1l protein
  • ptip protein
  • tnrc2 protein
  • wu:fa04b06 protein
  • zgc:92593 protein

Protein level used designations for PAXIP1

PAX transcription activation domain interacting protein 1 like , PAX-interacting protein 1 , protein encoded by CAG trinucleotide repeats , PAX transactivation activation domain-interacting protein , fa04b06 , SMAD wing for transcriptional activation , Swift , protein Swift , PAX interacting protein 1

GENE ID SPECIES
22976 Homo sapiens
449658 Danio rerio
398236 Xenopus laevis
482813 Canis lupus familiaris
513213 Bos taurus
55982 Mus musculus
311944 Rattus norvegicus
463836 Pan troglodytes
100455902 Pongo abelii
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