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PC4 and SFRS1 Interacting Protein 1 Proteins (PSIP1)

Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Additionally we are shipping PC4 and SFRS1 Interacting Protein 1 Antibodies (56) and PC4 and SFRS1 Interacting Protein 1 Kits (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PSIP1 11168 O75475
PSIP1 101739 Q99JF8
PSIP1 313323 Q812D1
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Top PC4 and SFRS1 Interacting Protein 1 Proteins at antibodies-online.com

Showing 10 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Rat His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$598.40
Details
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$668.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,505.33
Details
HOST_Baculovirus Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$197.86
Details
HOST_Escherichia coli (E. coli) Rat Un-conjugated   100 μg Log in to see 9 to 19 Days
$778.92
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$841.86
Details

PSIP1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)
,
Rat (Rattus) ,
,

More Proteins for PC4 and SFRS1 Interacting Protein 1 (PSIP1) Interaction Partners

Human PC4 and SFRS1 Interacting Protein 1 (PSIP1) interaction partners

  1. LEDGF/p75 Overexpression Attenuates Oxidative Stress-Induced (show SQSTM1 Proteins) Necrosis and Upregulates the Oxidoreductase ERP57/PDIA3/GRP58 (show PDIA3 Proteins) in Prostate Cancer

  2. common LEDGF/p75 interaction interface shared by JPO2 (show CDCA7L Proteins), PogZ, MLL1, IWS1 and HIV IN

  3. Results show that these antibodies are highly specific for dense fine speckles 70 protein DFS70/LEDGFp75 and do not target methyl CpG binding protein 2 (MeCP2 (show MECP2 Proteins)).

  4. LEDGF/p75 interacts with splicing factors, contributes to exon choice, and directs HIV-1 integration to transcription units that are highly spliced.

  5. Together, these results provide evidence for an Integrase/Pol mediated uptake of LEDGF/p75 in HIV-1 viral particles and a specific cleavage by HIV protease.

  6. Altogether, these results indicate that a complex containing LEDGF/p75, Iws1, and Spt6 participates in regulating postintegration steps of HIV latency.

  7. LEDGF and 44 other novel putative nuclear targets of human thioredoxin 1 have been identified.

  8. Results of the present work reinforce the association of PSIP1 gene and rs61744944 single nucleotide polymorphism with HIV-1 infection long-term nonprogressors status.

  9. Data show that the same site on integrase-binding domain (IBD) of lens epithelium-derived growth factor (LEDGF) is involved in binding to MLL (show MLL Proteins) protein and HIV-IN (integrase), indicating an approach to target LEDGF in both leukemia and HIV infection.

  10. Authors identified an additional LEDGF/p75-MLL (show MLL Proteins) interface, which overlaps with the binding site of known LEDGF/p75 interactors-HIV-1 integrase, PogZ, and JPO2 (show CDCA7L Proteins).

Mouse (Murine) PC4 and SFRS1 Interacting Protein 1 (PSIP1) interaction partners

  1. The role of Psip1 in cardiac development

  2. conclude that small peptides disrupting the LEDGF/p75-MLL (show MLL Proteins) interface have selective anti-leukemic activity providing a direct rationale for the design of small molecule inhibitors targeting this interaction

  3. Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration.

  4. Alcohol (ADH (show AVP Proteins)) and ALDH (show ALDH3A1 Proteins) dehydrogenases are implicated in cellular detoxification and conversion of vitamin A to RA. Lens epithelium-derived growth factor provides cellular protection against stress by transactivating stress-associated genes.

  5. Results suggest that TNF-alpha (show TNF Proteins) elevates the expression of lens epithelium-derived growth factor (LEDGF) and that LEDGF is one of the transactivators of gamma-glutamylcysteine synthetase heavy subunit (show GCLC Proteins) gene.

  6. These suggest a role for Psip1 in the control of Homeobox (show PRRX1 Proteins) expression and may also explain why PSIP1 (LEDGF) is found as a fusion partner with NUP98 (show NUP98 Proteins) in myeloid leukemias.

  7. some DFS70-positive sera have antibodies that recognize antigens of the lens

PC4 and SFRS1 Interacting Protein 1 (PSIP1) Protein Profile

Protein Summary

Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis (By similarity).

Gene names and symbols associated with PSIP1

  • PC4 and SFRS1 interacting protein 1 (psip1)
  • PC4 and SFRS1 interacting protein 1 (PSIP1)
  • PC4 and SFRS1 interacting protein 1 (LOC100230181)
  • PC4 and SFRS1 interacting protein 1 (LOC100339871)
  • LEDGF/p75 transcription factor-like (psip1)
  • PC4 and SFRS1 interacting protein 1 (Psip1)
  • AA408851 protein
  • AU015605 protein
  • Dfs70 protein
  • im:7149861 protein
  • Ledgf protein
  • LEDGF/p75 protein
  • Ledgfa protein
  • Ledgfb protein
  • p52 protein
  • p75 protein
  • PAIP protein
  • PSIP1 protein
  • Psip2 protein
  • SBP75 protein
  • zgc:109898 protein

Protein level used designations for PSIP1

PC4 and SFRS1 interacting protein 1 , LEDGF/p75 , PC4 and SFRS1-interacting protein , PC4 and SFRS1-interacting protein-like protein , Lens epithelium-derived growth factor , PC4 and SFRS1-interacting protein-like , putative LEDGF/p75 transcription factor , lens epithelium-derived growth factor , CLL-associated antigen KW-7 , DFS 70 , dense fine speckles 70 kDa protein , transcriptional coactivator p52/p75 , transcriptional coactivator p75/p52 , PC4 and SFRS1 interacting protein 2 , dense fine speckles 70 , mLEDGF , supercoiled DNA binding protein 75 , lens epithelium derived growth factor p75 , transcription coactivator p75

GENE ID SPECIES
398545 Xenopus laevis
465001 Pan troglodytes
553760 Danio rerio
100016299 Monodelphis domestica
100034217 Equus caballus
100145476 Xenopus (Silurana) tropicalis
100195391 Salmo salar
100230181 Taeniopygia guttata
100233239 Ovis aries
100339871 Oryctolagus cuniculus
100401055 Callithrix jacchus
100584230 Nomascus leucogenys
734236 Xenopus laevis
431605 Gallus gallus
11168 Homo sapiens
474712 Canis lupus familiaris
282011 Bos taurus
101739 Mus musculus
313323 Rattus norvegicus
493969 Felis catus
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