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PAX5 encodes a member of the paired box (PAX) family of transcription factors. Additionally we are shipping PAX5 Proteins (7) and PAX5 Kits (3) and many more products for this protein.
Showing 10 out of 174 products:
Human Monoclonal PAX5 Primary Antibody for IHC (p) - ABIN1687422
Steinert, Schenkel, Fraser, Beura, Manlove, Igyártó, Southern, Masopust: Quantifying Memory CD8 T Cells Reveals Regionalization of Immunosurveillance. in Cell 2015
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Human Monoclonal PAX5 Primary Antibody for FACS, IHC (p) - ABIN1687411
Zanelli, Valli, Capodanno, Ragazzi, Ascani: Anaplastic lymphoma kinase-positive large B-cell lymphoma: description of a case with an unexpected clinical outcome. in International journal of surgical pathology 2015
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Human Monoclonal PAX5 Primary Antibody for WB - ABIN394437
Okamoto, Ogawa, Nowak, Kawamata, Akagi, Kato, Sanada, Weiss, Haferlach, Dugas, Ruckert, Haferlach, Koeffler: Genomic profiling of adult acute lymphoblastic leukemia by single nucleotide polymorphism oligonucleotide microarray and comparison to pediatric acute lymphoblastic leukemia. in Haematologica 2010
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Human Polyclonal PAX5 Primary Antibody for EIA, WB - ABIN954009
Song, Li, Tretiakova, Salgia, Cagle, Husain: Expression patterns of PAX5, c-Met, and paxillin in neuroendocrine tumors of the lung. in Archives of pathology & laboratory medicine 2010
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Human Polyclonal PAX5 Primary Antibody for WB - ABIN493221
Wallin, Wilting, Koseki, Fritsch, Christ, Balling: The role of Pax-1 in axial skeleton development. in Development (Cambridge, England) 1994
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Human Monoclonal PAX5 Primary Antibody for ELISA, WB - ABIN969552
Coyaud, Struski, Prade, Familiades, Eichner, Quelen, Bousquet, Mugneret, Talmant, Pages, Lefebvre, Penther, Lippert, Nadal, Taviaux, Poppe, Luquet, Baranger, Eclache, Radford, Barin, Mozziconacci et al.: Wide diversity of PAX5 alterations in B-ALL: a Groupe Francophone de Cytogenetique Hematologique study. ... in Blood 2010
Show all 2 references for ABIN969552
Human Monoclonal PAX5 Primary Antibody for IHC, ELISA - ABIN1098104
OBrien, Morin, Ouellette, Robichaud: The Pax-5 gene: a pluripotent regulator of B-cell differentiation and cancer disease. in Cancer research 2011
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Human Polyclonal PAX5 Primary Antibody for WB - ABIN374250
Adams, Dörfler, Aguzzi, Kozmik, Urbánek, Maurer-Fogy, Busslinger: Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis. in Genes & development 1992
Chicken Polyclonal PAX5 Primary Antibody for IHC, WB - ABIN2775953
Robichaud, Nardini, Laflamme, Cuperlovic-Culf, Ouellette: Human Pax-5 C-terminal isoforms possess distinct transactivation properties and are differentially modulated in normal and malignant B cells. in The Journal of biological chemistry 2004
PAX2 (show PAX2 Antibodies) and PAX5 are useful biomarker in the differential diagnosis of lung cancer
Our findings suggest that this mutation in a single allele of the PAX5 gene is not sufficient to cause disease, and it is possible that other alleles are also involved in the onset of B-ALL.
PAX5 methylated imprint margins may signify recurrence in head and neck squamous cell carcinoma
Authors demonstrate leukemogenicity of PAX5-PML (show PML Antibodies) by introducing it into normal mouse pro-B cells; B-cell linker protein (Blnk (show BLNK Antibodies)) is repressed by PAX5-PML (show PML Antibodies) in leukemia cells; enforced expression of Blnk (show BLNK Antibodies) increases survival despite introduction of PAX5-PML (show PML Antibodies).
PAX5 deletion is an independent risk factor for DFS (show FST Antibodies) in B-ALL children.
Differential PAX5 levels promote malignant B-cell infiltration, progression and drug resistance, and predict a poor prognosis in mantle cell lymphoma patients independent (show CCND1 Antibodies) of CCND1.
This is the first reported case of a novel complex variant translocation of t(11;14)(q13;q32) and t(9;14)(p13;q32)in PAX5-positive plasma cell myeloma.
data suggested the differential regulation of hDAO expression by two promoters whose activities may be modulated by the binding of PAX2 (show PAX2 Antibodies) and PAX5
Cells from PAX5 translocated patients show LCK (show LCK Antibodies) up-regulation and over-activation, as well as STAT5 (show STAT5A Antibodies) hyper-phosphorylation, compared to PAX5 wt and PAX5 deleted cases.
Increased hypermethylation of PAX5 is associated with Triple negative breast cancer.
Pax5 transcription factor cooperates in patterning the Xenopus brain.
Differential PAX5 levels promote malignant B-cell infiltration, progression and drug resistance, and predict a poor prognosis in mantle cell lymphoma independent of CCND1 (show CCND1 Antibodies).
Spleen-specific isoform of Pax5 and Ataxin-7 (show ATXN7 Antibodies) can be considered as spleen-specific unique molecular markers for the evaluation of splenomegaly and lympho-proliferative disorders.
Pax5 and Ebf1 (show EBF1 Antibodies) collaborate to modulate the transcriptional response to Notch (show NOTCH1 Antibodies) signaling, and their combined heterozygous loss allows for T-lineage conversion of B cell progenitors.
a dramatic increase in the frequency of pro-B cell leukemia was observed in mice with combined heterozygous mutations in the Ebf1 (show EBF1 Antibodies) and Pax5 genes, revealing a synergistic effect of combined dose reduction of these proteins
These results show that in contrast to simple Pax5 haploinsufficiency, multiple sequential alterations targeting lymphoid development are central to leukemogenesis and contribute to the arrest in lymphoid maturation characteristic of ALL.
miR (show MLXIP Antibodies)-155 inhibits PU.1 expression, leading to Pax5 down-regulation and the initiation of the plasma cell differentiation pathway.
restoring endogenous Pax5 expression in established B-ALL triggers immunophenotypic maturation and durable disease remission by engaging a transcriptional program reminiscent of normal B-cell differentiation
Pax5 in GABAergic neurons is essential for normal ventricular development.
results suggest that osteoblastic Pax5 would play a role in ovariectomy-induced bone loss through a mechanism relevant to the promotion of both osteoblastic bone formation and osteoclastic bone resorption in vivo
Pax5 regulates Aicda (show AICDA Antibodies) transcription through its C-terminal-activation domain
pax5 works in conjunction with fgf3 (show FGF3 Antibodies) and pax2a to establish and/or maintain the utricular macula and is essential for vestibular function.
This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9\;14)(p13\;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.
paired box 5
, paired box gene 5 (B-cell lineage specific activator)
, paired box protein Pax-5
, paired box protein Pax-5-like
, B-cell lineage specific activator
, paired box homeotic gene 5
, paired domain gene 5
, transcription factor PAX 5
, B-cell-specific transcription factor
, Pax5 variant 1
, Pax5 variant 2
, No isthmus protein