PAX5 antibody (Paired Box 5) (N-Term)

Details for Product anti-PAX5 Antibody No. ABIN2775953, Supplier: Log in to see
Antigen
  • PAX5
  • BSAP
  • Pax-5
  • pax5-a
  • RGD1565236
  • EBB-1
  • KLP
  • Pax[Zf-b]
  • noi
  • pax2.1
  • pax2a
  • paxzf-b
  • paired box 5
  • paired box gene 5
  • PAX5
  • pax5
  • Pax5
Epitope
N-Term
26
25
24
14
12
10
9
8
5
4
4
3
2
2
2
2
2
2
2
2
1
1
1
1
Reactivity
Cow (Bovine), Dog (Canine), Guinea Pig, Horse (Equine), Human, Mouse (Murine), Rabbit, Rat (Rattus), Zebrafish
242
103
28
5
3
2
2
2
2
2
1
1
1
1
Host
Rabbit
129
62
35
16
Clonality
Polyclonal
Conjugate
This PAX5 antibody is un-conjugated
11
10
10
7
6
6
4
4
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), Western Blotting (WB)
176
94
84
63
54
21
13
6
6
3
3
2
2
1
1
1
1
Options
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Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human PAX5
Blocking Peptide Blocking peptide for this product available: ABIN981389
Sequence CVSKILGRYY ETGSIKPGVI GGSKPKVATP KVVEKIAEYK RQNPTMFAWE
Predicted Reactivity Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%
Characteristics This is a rabbit polyclonal antibody against PAX5. It was validated on Western Blot and immunohistochemistry.
Purification Affinity Purified
Alternative Name PAX5 (PAX5 Antibody Abstract)
Background The PAX5 gene is a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. The PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. The PAX5 gene encodes the B-cell lineage specific activator protein (BSAP) that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis, therefore, PAX5 gene product may not only play an important role in B-cell differentiation, but also in neural development and spermatogenesis.
Alias Symbols: BSAP
Protein Interaction Partner: TBP, RB1, EP300, RUNX1, TLE4, DAXX, KPNA1, KPNA2, ID2, ID3, CREBBP, MYB, PAX5, ETS1, EBF1,
Protein Size: 391
Molecular Weight 42 kDa
Gene ID 5079
NCBI Accession NM_016734, NP_057953
UniProt Q02548
Research Area Chromatin and Nuclear Signaling, Transcription Factors
Application Notes Optimal working dilutions should be determined experimentally by the investigator.
Comment

Antigen size: 391 AA

Restrictions For Research Use only
Format Liquid
Concentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freeze-thaw cycles.
Storage -20 °C
Storage Comment For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Supplier Images
Western Blotting (WB) image for anti-PAX5 antibody (Paired Box 5) (N-Term) (ABIN2775953) WB Suggested Anti-PAX5 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: ...
Immunohistochemistry (IHC) image for anti-PAX5 antibody (Paired Box 5) (N-Term) (ABIN2775953) anti-Paired Box 5 (PAX5) (N-Term) antibody (Image 2)
Background publications Robichaud, Nardini, Laflamme, Cuperlovic-Culf, Ouellette: "Human Pax-5 C-terminal isoforms possess distinct transactivation properties and are differentially modulated in normal and malignant B cells." in: The Journal of biological chemistry, Vol. 279, Issue 48, pp. 49956-63, 2004 (PubMed).