Paired Box 5 Proteins (PAX5)

PAX5 encodes a member of the paired box (PAX) family of transcription factors. Additionally we are shipping PAX5 Antibodies (244) and PAX5 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PAX5 5079 Q02548
Rat PAX5 PAX5 500453  
PAX5 18507 Q02650
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Top PAX5 Proteins at antibodies-online.com

Showing 6 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
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HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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Yeast Xenopus laevis His tag   1 mg Log in to see 60 to 71 Days
$3,070.83
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HOST_Escherichia coli (E. coli) Human Un-conjugated   5 applications Log in to see 1 to 2 Days
$312.71
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PAX5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine) ,

More Proteins for Paired Box 5 (PAX5) Interaction Partners

Human Paired Box 5 (PAX5) interaction partners

  1. These findings suggested that pax5 is critically important for the proliferation and survival of pre-B cells.

  2. a mechanism of transcriptional regulation mediated by p27 (show PAK2 Proteins), Pax5, and PCAF (show KAT2B Proteins)

  3. Data show that paired box gene 5 (B-cell lineage specific activator) protein (Pax-5) induces E-cadherin (show CDH1 Proteins) expression in breast cancer cells.

  4. a new function of PAX5 in regulating RIP1 and RIP2 activation, which is at least involved in chemotherapeutic drug resistance in B-lymphoproliferative disorders, is reported.

  5. PAX5-KIDINS220 fusion is associated with Philadelphia-like acute lymphoblastic leukemia.

  6. this study shows that Pax5 expression is lower in antibody-secreting cells than in naive B cells or plasmablasts

  7. The histological observations suggested that the patients represent diverse cases of NHL like mature B-cell type, mature T-cell type and high grade diffuse B-cell type NHL. The findings indicate that patients with NHL may also be analyzed for status of PAX5, CD19 and ZAP70, and their transcriptional and post-translational variants for the differential diagnosis of NHL and therapy.

  8. B cell receptor signaling component, SYK (show SYK Proteins), caused PAX5 tyrosine phosphorylation in vitro and in cells. Transcriptional repression on the BLIMP1 (show PRDM1 Proteins) promoter by PAX5 was attenuated by this phosphorylation.

  9. PAX5 haploinsufficiency promotes tumorigenesis and may be related to genomic instability, immune tolerance, and tumor pathways

  10. FISH studies showed false-negative results in 10, 40, and 28% of the samples tested for the IKZF1 (show IKZF1 Proteins),PAX5, and CDKN2A/B gene deletions, respectively. The PAX5 and IKZF1 (show IKZF1 Proteins) abnormalities are highly specific to B (show TDO2 Proteins)-ALL and can be used as diagnostic markers

Xenopus laevis Paired Box 5 (PAX5) interaction partners

  1. Pax5 transcription factor cooperates in patterning the Xenopus brain.

Mouse (Murine) Paired Box 5 (PAX5) interaction partners

  1. identify Pax5 and cyclin D1 as Zfp521 target genes

  2. Together with similar observations made in human PAX5-ETV6 (show ETV6 Proteins)(+) B-ALLs, these data identified PAX5-ETV6 (show ETV6 Proteins) fusion as a potent oncoprotein that drives B-cell leukemia development.

  3. PAX5 was found to be an epigenetically inactivated tumor suppressor that inhibited non-small-cell lung proliferation and metastasis, through down-regulating the beta-catenin (show CTNNB1 Proteins) pathway and up-regulating GADD45G (show GADD45G Proteins) expression.

  4. Differential PAX5 levels promote malignant B-cell infiltration, progression and drug resistance, and predict a poor prognosis in mantle cell lymphoma independent of CCND1 (show CCND1 Proteins).

  5. Spleen-specific isoform of Pax5 and Ataxin-7 can be considered as spleen-specific unique molecular markers for the evaluation of splenomegaly and lympho-proliferative disorders.

  6. Pax5 and Ebf1 (show EBF1 Proteins) collaborate to modulate the transcriptional response to Notch (show NOTCH1 Proteins) signaling, and their combined heterozygous loss allows for T-lineage conversion of B cell progenitors.

  7. a dramatic increase in the frequency of pro-B cell leukemia was observed in mice with combined heterozygous mutations in the Ebf1 (show EBF1 Proteins) and Pax5 genes, revealing a synergistic effect of combined dose reduction of these proteins

  8. These results show that in contrast to simple Pax5 haploinsufficiency, multiple sequential alterations targeting lymphoid development are central to leukemogenesis and contribute to the arrest in lymphoid maturation characteristic of ALL.

  9. miR (show MLXIP Proteins)-155 inhibits PU.1 expression, leading to Pax5 down-regulation and the initiation of the plasma cell differentiation pathway.

  10. restoring endogenous Pax5 expression in established B-ALL triggers immunophenotypic maturation and durable disease remission by engaging a transcriptional program reminiscent of normal B-cell differentiation

Zebrafish Paired Box 5 (PAX5) interaction partners

  1. pax5 works in conjunction with fgf3 (show FGF3 Proteins) and pax2a to establish and/or maintain the utricular macula and is essential for vestibular function.

PAX5 Protein Profile

Protein Summary

This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9\;14)(p13\;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.

Gene names and symbols associated with Paired Box 5 Proteins (PAX5)

  • paired box 5 (PAX5)
  • paired box 5 (pax5)
  • paired box 5 (Pax5)
  • paired box gene 5 (Pax5)
  • paired box gene 5 (pax5)
  • BSAP protein
  • EBB-1 protein
  • KLP protein
  • noi protein
  • Pax-5 protein
  • pax2.1 protein
  • pax2a protein
  • PAX5 protein
  • pax5-a protein
  • paxzf-b protein
  • Pax[Zf-b] protein
  • RGD1565236 protein

Protein level used designations for Paired Box 5 Proteins (PAX5)

paired box 5 , paired box gene 5 (B-cell lineage specific activator) , paired box protein Pax-5 , paired box protein Pax-5-like , B-cell lineage specific activator , paired box homeotic gene 5 , paired domain gene 5 , transcription factor PAX 5 , XPax-5 , B-cell-specific transcription factor , Pax5 variant 1 , Pax5 variant 2 , No isthmus protein

GENE ID SPECIES
716839 Macaca mulatta
747452 Pan troglodytes
100055252 Equus caballus
100389113 Callithrix jacchus
100457719 Pongo abelii
100481668 Ailuropoda melanoleuca
100586040 Nomascus leucogenys
5079 Homo sapiens
378499 Xenopus laevis
387330 Gallus gallus
612021 Canis lupus familiaris
500453 Rattus norvegicus
100520167 Sus scrofa
538371 Bos taurus
18507 Mus musculus
60636 Danio rerio
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