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Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.. Additionally we are shipping and many more products for this protein.
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The formation of endoderm-derived taste sensory organs requires a Pax9-dependent expansion of embryonic taste bud progenitor cells. A primary function for Pax9 in the expansion of taste progenitor fields in taste papillae.
Transfection of Pax9 and Bmp4 (show BMP4 ELISA Kits) into mouse induced pluripotent stem cells facilitates their differentiation into odontoblast-like cells for cell- and tissue-based therapy.
Disruption of Slc25a21 (show Slc25a21 ELISA Kits) is associated with orofacial defects and otitis media due to diminished expression of a neighboring gene, pax9.
Our data indicate that Pax9 regulates a molecular network involving the Bmp4, Fgf10, Shh and Osr2 pathways to control palatal shelf patterning and morphogenesis.
the transcription factors Pax3 (show PAX3 ELISA Kits) and Pax9 as redundant regulators of mouse heterochromatin, as they repress RNA output from major satellite repeats by associating with DNA within pericentric heterochromatin
Mice lacking both Osr2 and Pax9 exhibited early tooth developmental arrest with significantly reduced Bmp4 (show BMP4 ELISA Kits) and Msx1 (show MSX1 ELISA Kits) mRNA expression in the developing tooth mesenchyme.
Genetic interactions between Pax9 and Msx1 (show MSX1 ELISA Kits) regulate lip development and several stages of tooth morphogenesis.
Thymopoiesis requires Pax9 function in thymic epithelial cells. In Pax9 null mice, the thymic anlage develops as an ectopic polyp-like structure in the larynx, fails to perform the normal caudo-ventral movement to the upper mediastinum, and remains small.
Pax1 (show PAX1 ELISA Kits) and Pax9 can transactivate regulatory sequences in the Bapx1 (show NKX3-2 ELISA Kits) promoter to induce chondrogenic differentiation in the sclerotome.
PAX9 has a role in tooth development in humans
Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs.
paired box gene 9
, paired box protein Pax-9