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PON2 encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. Additionally we are shipping PON2 Antibodies (108) and PON2 Kits (20) and many more products for this protein.
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The PON2 Ser311Cys polymorphism is associated with coronary heart disease risk in Caucasians.
Thi study found that the CC genotype of the PON2 S311C polymorphism is a risk factor for ischemic stroke.
Studies indicate that three paraoxonases PON1 (show PON1 Proteins), PON2, and PON3 (show PON3 Proteins) genes are clustered on chromosome 7, and that PONs possess numerous atheroprotective properties.
PON2 SNPs rs12026 and rs7493 were associated with intracerebral hemorrhage. The C alleles of rs12026 and rs7493 contributed to a decreased risk of ICH (show COL4a2 Proteins).
Data indicate the relationship between ubiqutination of lysine (Lys (show LYZ Proteins)) 168 and paraoxonase 2 (PON2) catalytic activity.
Data suggest cigarette smoke leads to inhibition of hydrolytic activity of paraoxonase isoenzymes (PON1 (show PON1 Proteins), PON2, PON3 (show PON3 Proteins)) by modification of thiol groups, by interactions with free radicals/heavy metals, or by decreasing HDL (show HSD11B1 Proteins) level in blood. [REVIEW]
Haplotype containing two risk alleles of PON1 (show PON1 Proteins) and PON2 genes was significantly associated with disease diabetes mellitus, type 2.
D1-like receptors inhibit ROS (show ROS1 Proteins) production by altering PON2 distribution in membrane microdomains in the short-term, and by increasing PON2 expression in the long-term.
PON2 is a central regulator of host cell responses to Pseudomonas aeruginosa N-(3-oxo-dodecanoyl)-L-homoserine lactone
PON2 levels reflect the cells' irradiation sensitivity.
PON2 plays an important role in innate immune defense against Pseudomonas aeruginosa infection.
macrophage triglyceride accumulation upregulates PON2 expression via MEK (show MDK Proteins)/ JNK/c-Jun pathway, and these effects could be related, at least in part, to cellular triglycerides-induced ROS (show ROS1 Proteins) formation.
These results suggest that PON2 is a novel major intracellular factor that protects CNS cells against oxidative stress and confers gender-dependent susceptibility to such stress
Macrophage PON2 modulates mechanisms that link endoplasmic reticulum stress, mitochondrial dysfunction and the development of atherosclerosis.
results demonstrate that PON2 plays an important role in hepatic insulin (show INS Proteins) signalling and underscores the influence of macrophage-mediated inflammatory response on hepatic insulin (show INS Proteins) sensitivity.
Results illustrate that the antiatherogenic effects of PON2 are, in part, mediated by the role of PON2 in mitochondrial function.
Under normal conditions macrophage endoplasmic reticulum stabilizes PON2 activity, and this effect could be attributed to ER proteins and redox status.
PON2 proteins were present in the vast majority of tissues investigated. mRNA for these proteins was also expressed in most of these tissues suggesting local production and the ability to respond in situ to inflammatory stimuli.
Pomegranite juice consumption antioxidative properties on mouse macrophages are mediated via PJ-induced stimulation of macrophage PON2 expression.
analysis of macrophage cholesterol biosynthesis and decreased cellular paraoxonase 2 (PON2) expression in Delta6-desaturase knockout (6-DS KO) mice
The expression of the PON2 gene was greater in Meishan pig than that in Yorkshire on gestational day 26 and 90.
The aim of this study was to evaluate expression of the natural anti-oxidants paraoxonase (PON) 1 (show PON1 Proteins), 2 and 3 in granulosa cells and PON1 (show PON1 Proteins) activity in follicular fluid and plasma of dairy cows.
This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described.
, Aromatic esterase 2
, PON 2
, Serum aryldialkylphosphatase 2
, Serum paraoxonase/arylesterase 2
, paraoxonase 2
, celiac disease 2
, serum paraoxonase/arylesterase 2-like
, serum paraoxonase/arylesterase 2
, aromatic esterase 2
, paraoxonase nirs
, serum aryldialkylphosphatase 2