Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) ELISA Kits

The precise function of PARK2 is unknown\; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Additionally we are shipping PARK2 Antibodies (176) and PARK2 Proteins (11) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
PARK2 50873 Q9WVS6
PARK2 56816 Q9JK66
PARK2 5071 O60260
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Top PARK2 ELISA Kits at antibodies-online.com

Showing 4 out of 18 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Mouse 0.78 pg/mL 3.12-200 pg/mL Typical standard curve 96 Tests Log in to see 15 to 18 Days
$910.56
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Human 0.053 ng/mL 0.15-10 ng/mL   96 Tests Log in to see 13 to 16 Days
$648.42
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Human
  96 Tests Log in to see 11 Days
$848.18
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Rat
  96 Tests Log in to see 15 to 18 Days
$875.60
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More ELISA Kits for PARK2 Interaction Partners

Fruit Fly (Drosophila melanogaster) Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) interaction partners

  1. Our data indicate that PINK1 and Parkin play an important role in FUS (show FUS ELISA Kits)-induced neurodegeneration. This study has uncovered a previously unknown link between FUS (show FUS ELISA Kits) proteinopathy and PINK1/Parkin genes, providing new insights into the pathogenesis of FUS (show FUS ELISA Kits) proteinopathy.

  2. Clu (show CLU ELISA Kits) is upstream of and binds to VCP (show vcp ELISA Kits) in vivo and promotes VCP (show vcp ELISA Kits)-dependent Marf (show MFN2 ELISA Kits) degradation in vitro Marf (show MFN2 ELISA Kits) accumulates in whole muscle lysates of clu (show CLU ELISA Kits)-deficient flies and is destabilized upon Clu (show CLU ELISA Kits) overexpression. Thus, Clu (show CLU ELISA Kits) is essential for mitochondrial homeostasis and functions in concert with Parkin and VCP (show vcp ELISA Kits) for Marf (show MFN2 ELISA Kits) degradation to promote damaged mitochondrial clearance.

  3. Buffy has a role enhancing the loss of parkin and suppressing the loss of Pink1 phenotypes in Drosophila

  4. Parkin-dependent mitophagy suppresses neural neurodegeneration by removing damaged mitochondria.

  5. We demonstrate here that vps35 (show vps35 ELISA Kits) genetically interacts with parkin

  6. Clu directly modulates mitochondrial function, and that Clu's function contributes to the PINK1-Park pathway of mitochondrial quality control.

  7. Human Mask homolog ANKHD1 (show ANKHD1 ELISA Kits) may serve as a potential therapeutic target for treating Parkinson disease caused by pink1/parkin mutations.

  8. These results indicate that the in vivo rescue is due to restoring CI activity rather than promoting mitophagy Our findings support the emerging view that PINK1 plays a role in regulating CI activity separate from its role with Parkin in mitophagy

  9. MUL1 acts in parallel to the PINK1/parkin pathway on a shared target mitofusin (show MFN2 ELISA Kits) to maintain mitochondrial integrity.

  10. Parkin cooperates with PINK1 to promote hnRNP-F/Glo ubiquitination and nRCC mRNA translation.

Zebrafish Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) interaction partners

  1. Melatonin, added together with MPTP or added once MPTP was removed, prevented and recovered, respectively, the parkinsonian phenotype once it was established, restoring gene expression and normal function of the parkin/PINK1/DJ-1/MUL1 loop and also the normal motor activity of the embryos.

Mouse (Murine) Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) interaction partners

  1. These findings suggest that insufficient mitophagy-mediated PDGFR (show PDGFRB ELISA Kits)/PI3K/AKT (show AKT1 ELISA Kits) activation, which is mainly attributed to reduced PARK2 expression, is a potent underlying mechanism for myofibroblast differentiation and proliferation in fibroblastic foci formation during idiopathic pulmonary fibrosis pathogenesis

  2. Mfn2 (show MFN2 ELISA Kits) downregulation or the exogenous expression of normal Parkin restored cytosolic Ca(2 (show CA2 ELISA Kits)+) transients in fibroblasts from patients with PARK2 mutations, a catalytically inactive Parkinson's disease (PD)-related Parkin variant had no effect. Parkin is directly involved in regulating ER-mitochondria contacts and provide new insight into the role of the loss of Parkin function in PD development

  3. Our results provide a molecular explanation for the contribution of Drp1 (show CRMP1 ELISA Kits) to the pathogenesis of sporadic Parkinson's disease (PD). These findings indicate that the SNO (show SBNO2 ELISA Kits)-Parkin pathway may be a novel therapeutic target to treat PD

  4. These results suggest a previously unidentified role of parkin in mediating endotoxin-induced endothelial proinflammatory signaling and indicate that it may play a critical role in acute inflammation.

  5. These studies suggest that changes in intestinal lipid absorption may play a primary role in protection from nutritional stress in Park2 KO mice by preventing HFD-induced weight gain and highlight the need for tissue-specific models to address the role of PARK2 during metabolic stress.

  6. Parkin negatively regulates the number and connectivity of mitochondria via a Drp1 (show CRMP1 ELISA Kits)-independent mechanism.

  7. Parkin-overexpressing cells also showed reductions in apoptotic BAX (show BAX ELISA Kits) translocation to the mitochondria and cytochrome c (show CYCS ELISA Kits) release to the cytosol

  8. Parkin protects against oxygen-glucose deprivation/reperfusion insult by promoting degradation of Drp1 (show CRMP1 ELISA Kits).

  9. The identification of PINK1 and Parkin as suppressors of an immune-response-eliciting pathway provoked by inflammation suggests new insights into Parkinson's disease pathology.

  10. p62 (show GTF2H1 ELISA Kits) are subjected to parkin mediated proteasomal degradation

Human Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) interaction partners

  1. Neurodegeneration in Parkinson's patients harboring homozygous loss-of-function mutations in the PARK2 gene may result from unbalanced levels of ROS (show ROS1 ELISA Kits), which are mostly produced in mitochondria and can irreparably damage macromolecules and trigger apoptosis.

  2. These findings suggest that insufficient mitophagy-mediated PDGFR (show PDGFRB ELISA Kits)/PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits) activation, which is mainly attributed to reduced PARK2 expression, is a potent underlying mechanism for myofibroblast differentiation and proliferation in fibroblastic foci formation during idiopathic pulmonary fibrosis pathogenesis

  3. PKA-mediated phosphorylation of MIC60 negatively regulates mitochondrial clearance that is initiated by PINK1 and Parkin.

  4. Mfn2 (show MFN2 ELISA Kits) downregulation or the exogenous expression of normal Parkin restored cytosolic Ca(2 (show CA2 ELISA Kits)+) transients in fibroblasts from patients with PARK2 mutations, a catalytically inactive Parkinson's disease (PD)-related Parkin variant had no effect. Parkin is directly involved in regulating ER-mitochondria contacts and provide new insight into the role of the loss of Parkin function in PD development

  5. This study found that Parkin-deficient animals do not accumulate senescent mitochondria in their motor axons or neuromuscular junctions.

  6. Our study provided sufficient information and insight for investigation of PARK-2 and highlighted its role as a tumor suppressor gene in cervical cancer in North Indian population

  7. The authors now report the crystal structure of a human Parkin-phosphoubiquitin complex, which shows that phosphoubiquitin binding induces movement in the 'in-between RING' (IBR) domain to reveal a cryptic ubiquitin-binding site.

  8. These results suggest a previously unidentified role of parkin in mediating endotoxin-induced endothelial proinflammatory signaling and indicate that it may play a critical role in acute inflammation.

  9. Dopa-responsive dystonia phenotype may have heterogeneous genetic background and may be caused by point mutations or rearrangements in the GCH1 (show GCH1 ELISA Kits) gene as well as in the PARK2 gene.

  10. study highlights the novel role of parkin in antiviral signaling

Pig (Porcine) Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) interaction partners

  1. Single nucleotide polymorphism (SNP) analysis revealed seven SNPs in the porcine PARK2 gene, one missense and one silent mutation in exon 7 and five SNPs in intron 7

PARK2 Antigen Profile

Antigen Summary

The precise function of this gene is unknown\; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.

Gene names and symbols associated with PARK2

  • parkin (park) antibody
  • Parkinson disease (autosomal recessive, juvenile) 2, parkin (park2) antibody
  • parkinson protein 2, E3 ubiquitin protein ligase (parkin) (PARK2) antibody
  • parkin (CpipJ_CPIJ014867) antibody
  • Parkinson disease (autosomal recessive, juvenile) 2, parkin (LOC100150461) antibody
  • Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) antibody
  • parkinson protein 2, E3 ubiquitin protein ligase (Park2) antibody
  • parkinson protein 2, E3 ubiquitin protein ligase (parkin) (Park2) antibody
  • AR-JP antibody
  • CG10523 antibody
  • Dmel\\CG10523 antibody
  • Dpark antibody
  • dpk antibody
  • LOC100150461 antibody
  • LPRS2 antibody
  • Park antibody
  • PDJ antibody
  • pdr-1 antibody
  • Prkn antibody
  • SD01679 antibody
  • si:ch211-123f21.1 antibody
  • zgc:112390 antibody

Protein level used designations for PARK2

CG10523-PB , CG10523-PC , D-parkin , dparkin , park-PB , park-PC , E3 ubiquitin-protein ligase parkin , parkin , Parkinson disease (autosomal recessive, juvenile) 2, parkin , parkin protein , parkin variant SV5DEL , parkinson juvenile disease protein 2

GENE ID SPECIES
40336 Drosophila melanogaster
550328 Danio rerio
741350 Pan troglodytes
6049109 Culex quinquefasciatus
100150461 Danio rerio
50873 Mus musculus
56816 Rattus norvegicus
5071 Homo sapiens
612316 Canis lupus familiaris
733673 Sus scrofa
100724550 Cavia porcellus
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