Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) ELISA Kits

The precise function of PARK2 is unknown\; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Additionally we are shipping PARK2 Antibodies (178) and PARK2 Proteins (11) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
PARK2 50873 Q9WVS6
PARK2 56816 Q9JK66
PARK2 5071 O60260
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top PARK2 ELISA Kits at antibodies-online.com

Showing 4 out of 18 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.053 ng/mL 0.156-10 ng/mL 96 Tests Log in to see 15 to 17 Days
$983.85
Details
Mouse 0.78 pg/mL 3.12-200 pg/mL Typical standard curve 96 Tests Log in to see 15 to 18 Days
$910.56
Details
Human
  96 Tests Log in to see 11 Days
$848.18
Details
Rat
  96 Tests Log in to see 15 to 18 Days
$875.60
Details

More ELISA Kits for PARK2 Interaction Partners

Fruit Fly (Drosophila melanogaster) Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) interaction partners

  1. activation of endoplasmic reticulum stress by defective mitochondria is neurotoxic in pink1 and parkin flies and that the reduction of this signalling is neuroprotective, independently of defective mitochondria.

  2. Pharmacological or genetic activation of heat shock protein 70 (Hsp70) protects against loss of parkin Function. Heat shock protein members may act as compensatory factors for parkin loss of function and that the exploitation of these factors may be of potential therapeutic value.

  3. autophosphorylation of PINK1 is essential for the mitochondrial translocation of Parkin and for subsequent phosphorylation and activation of Parkin.

  4. Our data indicate that PINK1 and Parkin play an important role in FUS (show FUS ELISA Kits)-induced neurodegeneration. This study has uncovered a previously unknown link between FUS (show FUS ELISA Kits) proteinopathy and PINK1/Parkin genes, providing new insights into the pathogenesis of FUS (show FUS ELISA Kits) proteinopathy.

  5. Clu (show CLU ELISA Kits) is upstream of and binds to VCP (show vcp ELISA Kits) in vivo and promotes VCP (show vcp ELISA Kits)-dependent Marf (show MFN2 ELISA Kits) degradation in vitro Marf (show MFN2 ELISA Kits) accumulates in whole muscle lysates of clu (show CLU ELISA Kits)-deficient flies and is destabilized upon Clu (show CLU ELISA Kits) overexpression. Thus, Clu (show CLU ELISA Kits) is essential for mitochondrial homeostasis and functions in concert with Parkin and VCP (show vcp ELISA Kits) for Marf (show MFN2 ELISA Kits) degradation to promote damaged mitochondrial clearance.

  6. Buffy has a role enhancing the loss of parkin and suppressing the loss of Pink1 phenotypes in Drosophila

  7. Parkin-dependent mitophagy suppresses neural neurodegeneration by removing damaged mitochondria.

  8. We demonstrate here that vps35 (show vps35 ELISA Kits) genetically interacts with parkin

  9. Clu directly modulates mitochondrial function, and that Clu's function contributes to the PINK1-Park pathway of mitochondrial quality control.

  10. Human Mask homolog ANKHD1 (show ANKHD1 ELISA Kits) may serve as a potential therapeutic target for treating Parkinson disease caused by pink1/parkin mutations.

Zebrafish Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) interaction partners

  1. Melatonin, added together with MPTP or added once MPTP was removed, prevented and recovered, respectively, the parkinsonian phenotype once it was established, restoring gene expression and normal function of the parkin/PINK1/DJ-1/MUL1 loop and also the normal motor activity of the embryos.

Mouse (Murine) Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) interaction partners

  1. These findings suggest that insufficient mitophagy-mediated PDGFR (show PDGFRB ELISA Kits)/PI3K/AKT (show AKT1 ELISA Kits) activation, which is mainly attributed to reduced PARK2 expression, is a potent underlying mechanism for myofibroblast differentiation and proliferation in fibroblastic foci formation during idiopathic pulmonary fibrosis pathogenesis

  2. Mfn2 (show MFN2 ELISA Kits) downregulation or the exogenous expression of normal Parkin restored cytosolic Ca(2 (show CA2 ELISA Kits)+) transients in fibroblasts from patients with PARK2 mutations, a catalytically inactive Parkinson's disease (PD)-related Parkin variant had no effect. Parkin is directly involved in regulating ER-mitochondria contacts and provide new insight into the role of the loss of Parkin function in PD development

  3. Our results provide a molecular explanation for the contribution of Drp1 (show CRMP1 ELISA Kits) to the pathogenesis of sporadic Parkinson's disease (PD). These findings indicate that the SNO (show SBNO2 ELISA Kits)-Parkin pathway may be a novel therapeutic target to treat PD

  4. These results suggest a previously unidentified role of parkin in mediating endotoxin-induced endothelial proinflammatory signaling and indicate that it may play a critical role in acute inflammation.

  5. These studies suggest that changes in intestinal lipid absorption may play a primary role in protection from nutritional stress in Park2 KO mice by preventing HFD-induced weight gain and highlight the need for tissue-specific models to address the role of PARK2 during metabolic stress.

  6. Parkin negatively regulates the number and connectivity of mitochondria via a Drp1 (show CRMP1 ELISA Kits)-independent mechanism.

  7. Parkin-overexpressing cells also showed reductions in apoptotic BAX (show BAX ELISA Kits) translocation to the mitochondria and cytochrome c (show CYCS ELISA Kits) release to the cytosol

  8. Parkin protects against oxygen-glucose deprivation/reperfusion insult by promoting degradation of Drp1 (show CRMP1 ELISA Kits).

  9. The identification of PINK1 and Parkin as suppressors of an immune-response-eliciting pathway provoked by inflammation suggests new insights into Parkinson's disease pathology.

  10. p62 (show GTF2H1 ELISA Kits) are subjected to parkin mediated proteasomal degradation

Human Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) interaction partners

  1. Adipogenic process can be dissected into 3 stages according to the participation of PARL (show PARL ELISA Kits)-PINK1-Parkin system. Findings reveal the sequential adipogenic events directed by PARL (show PARL ELISA Kits)-PINK1-Parkin system, add more evidence supporting the convergence of pathogenesis leading to neurodegenerative and metabolic disease

  2. These results highlight the combined effects of Parkin and PGC-1alpha (show PPARGC1A ELISA Kits) in the maintenance of mitochondrial homeostasis in dopaminergic neurons. These two factors synergistically control the quality and function of mitochondria, which is important for the survival of neurons in Parkinson's disease.

  3. Data suggest that inactivation of cytosolic parkin in dopaminergic neurons of the substantia nigra contributes to neurodegeneration in sporadic Parkinson disease. [REVIEW]

  4. we identified a genome-wide significant association involving measures of midface height at 6q26 within an intron of PARK2

  5. PARK2 inactivation connects energy and oxidative stress to Akt activation via redox-mediated inactivation of PTEN by S-nitrosylation to support cell survival under conditions of energy deprivation.

  6. These results suggest that degradation of endogenous APE1 (show APEX1 ELISA Kits) by Parkin occur when cells are stressed to activate Parkin, and imply a role of Parkin in maintaining the quality of APE1 (show APEX1 ELISA Kits), and loss of Parkin may contribute to elevated APE1 (show APEX1 ELISA Kits) levels in glioblastoma.

  7. Neurodegeneration in Parkinson's patients harboring homozygous loss-of-function mutations in the PARK2 gene may result from unbalanced levels of ROS (show ROS1 ELISA Kits), which are mostly produced in mitochondria and can irreparably damage macromolecules and trigger apoptosis.

  8. These findings suggest that insufficient mitophagy-mediated PDGFR (show PDGFRB ELISA Kits)/PI3K (show PIK3CA ELISA Kits)/AKT (show AKT1 ELISA Kits) activation, which is mainly attributed to reduced PARK2 expression, is a potent underlying mechanism for myofibroblast differentiation and proliferation in fibroblastic foci formation during idiopathic pulmonary fibrosis pathogenesis

  9. PKA-mediated phosphorylation of MIC60 negatively regulates mitochondrial clearance that is initiated by PINK1 and Parkin.

  10. Mfn2 (show MFN2 ELISA Kits) downregulation or the exogenous expression of normal Parkin restored cytosolic Ca(2 (show CA2 ELISA Kits)+) transients in fibroblasts from patients with PARK2 mutations, a catalytically inactive Parkinson's disease (PD)-related Parkin variant had no effect. Parkin is directly involved in regulating ER-mitochondria contacts and provide new insight into the role of the loss of Parkin function in PD development

Pig (Porcine) Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) interaction partners

  1. Single nucleotide polymorphism (SNP) analysis revealed seven SNPs in the porcine PARK2 gene, one missense and one silent mutation in exon 7 and five SNPs in intron 7

PARK2 Antigen Profile

Antigen Summary

The precise function of this gene is unknown\; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.

Gene names and symbols associated with PARK2

  • parkin (park) antibody
  • Parkinson disease (autosomal recessive, juvenile) 2, parkin (park2) antibody
  • parkinson protein 2, E3 ubiquitin protein ligase (parkin) (PARK2) antibody
  • parkin (CpipJ_CPIJ014867) antibody
  • Parkinson disease (autosomal recessive, juvenile) 2, parkin (LOC100150461) antibody
  • Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) antibody
  • parkinson protein 2, E3 ubiquitin protein ligase (Park2) antibody
  • parkinson protein 2, E3 ubiquitin protein ligase (parkin) (Park2) antibody
  • AR-JP antibody
  • CG10523 antibody
  • Dmel\\CG10523 antibody
  • Dpark antibody
  • dpk antibody
  • LOC100150461 antibody
  • LPRS2 antibody
  • Park antibody
  • PDJ antibody
  • pdr-1 antibody
  • Prkn antibody
  • SD01679 antibody
  • si:ch211-123f21.1 antibody
  • zgc:112390 antibody

Protein level used designations for PARK2

CG10523-PB , CG10523-PC , D-parkin , dparkin , park-PB , park-PC , E3 ubiquitin-protein ligase parkin , parkin , Parkinson disease (autosomal recessive, juvenile) 2, parkin , parkin protein , parkin variant SV5DEL , parkinson juvenile disease protein 2

GENE ID SPECIES
40336 Drosophila melanogaster
550328 Danio rerio
741350 Pan troglodytes
6049109 Culex quinquefasciatus
100150461 Danio rerio
50873 Mus musculus
56816 Rattus norvegicus
5071 Homo sapiens
612316 Canis lupus familiaris
733673 Sus scrofa
100724550 Cavia porcellus
Selected quality suppliers for PARK2 (PARK2) ELISA Kits
Did you look for something else?