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In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Additionally we are shipping and many more products for this protein.
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Human Polyclonal PEG3 Primary Antibody for IF (p), IHC (p) - ABIN735653
Ge, Liang, Luo, Wei, Han, Schatten, Sun, Zhang: Diabetic uterus environment may play a key role in alterations of DNA methylation of several imprinted genes at mid-gestation in mice. in Reproductive biology and endocrinology : RB&E 2014
Show all 2 references for ABIN735653
Cow (Bovine) Polyclonal PEG3 Primary Antibody for WB - ABIN2780754
Dowdy, Gostout, Shridhar, Wu, Smith, Podratz, Jiang: Biallelic methylation and silencing of paternally expressed gene 3 (PEG3) in gynecologic cancer cell lines. in Gynecologic oncology 2005
Porcine skeletal muscle-derived PW1(pos)/Pax7 (show PAX7 Antibodies)(neg (show TMEM131 Antibodies)) interstitial cells are a source of stem/progenitor cells.
The PEG3 gene expression was not affected by day of pregnancy or breed.
For PEG3, pigs expressed the paternal allele in skeletal muscle, liver, spleen, kidney, and uterus, but biallele in heart, lung, fat, stomach, small intestine, and ovary.
Peg3 transcriptionally modulates BECN1 (show BECN1 Antibodies) activity.
Data indicate that a set of cis (show CISH Antibodies)-regulatory motifs and corresponding trans factors that may be critical for the transcriptional regulation of the Peg3 (Paternally Expressed Gene 3) domain.
In the current study, the authors have identified three alternative promoters for mouse Peg3 and one alternative promoter for human PEG3.
A resident population of resident smooth muscle progenitor cells expressing PW1 was identified in pulmonary hypertension-associated vascular remodeling.
PW1/Peg3 function is essential for conferring proper mesoangioblast competence and it's level in human mesoangioblasts may serve as a biomarker to identify donor populations for therapeutic application in muscular dystrophies.
The PEG3-SCAN domain appears to constitute an assembly block, enabling PEG3 homo- or heterodimerization to control gene expression in a combinatorial fashion.
Genetic translocations involving PEG3 gene is associated with mesenchymal hamartoma of the liver.
we have unveiled a mechanism for a secreted proteoglycan (show Vcan Antibodies) in inducing Peg3, a master regulator of macroautophagy in endothelial cells
Results show that a five percent increase in DNA methylation (show HELLS Antibodies) of PEG3 is associated with a 1.6-fold increase invasive cervical cancer (ICC) risk.
None of the folate cycle genotypes in the mother or infant were related to the methylation of IGF2, PEG3, or LINE-1.
the expression of PEG3 domain genes within the maternal placenta is not significantly affected by the MIMT1Del mutation and alterations in PEG3 domain gene expression on the fetal side
Data show that a 110 kb microdeletion in the maternally imprinted PEG3 domain that results in a loss of paternal MIMT1 expression and causes late term abortion and stillbirth.
Peg3 was seriously demethylated or showed aberrant methylation patterns in four aborted clones.
PEG3 imprinted domain of humans, cows, and mice contains differing numbers of differentially methylated regions (DMR (show WDR20 Antibodies)), but the PEG3-CpG island is the only DMR (show WDR20 Antibodies) that is conserved among these three species.
promoters of Peg3 derive sexually biased and tissue-specific expression patterns
Our study also identified the imprinting control region (ICR) of H19 (show NCKAP1 Antibodies) as a genomic target. According to the results, PEG3 binds to a specific sequence motif located between the 3(rd) and 4(th) CTCF (show CTCF Antibodies) binding sites of the H19 (show NCKAP1 Antibodies)-ICR. PEG3 also binds to the active maternal allele of the H19 (show NCKAP1 Antibodies)-ICR.
These results support a general role for Pw1/Peg3 in the regulation of body growth but not maternal care and lactation.
Data show that bisperoxovanadium (BpV) treatment induces specific epigenetic modifications at the promoter regions of genes associated with stem cell fate, including Sca-1 (show Ly6a Antibodies) and Pw1.
5'-GTGGCAGT-3'is a DNA-binding motif of PEG3.
the milk letdown process was impaired in nursing females with the Peg3 mutation in the mammary gland, but not in the hypothalamus suggesting that Peg3's roles in the milk letdown process are more critical in the mammary gland than in the hypothalamus.
Study reports, for the first time, the bi-allelic expression of Peg3 in specific areas of mouse brain.
these results demonstrated that paternally expressed Peg3 controls maternally expressed Zim1 as a trans factor.
Oocytes vitrification could lead to the loss of DNA methylation (show HELLS Antibodies) of imprinted genes (H19 (show NCKAP1 Antibodies), Peg3, and Snrpn (show SNRPN Antibodies)) in mouse blastocysts, which is mainly caused by the reductions of DNMTs after vitrification of oocytes.
In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms.
paternally expressed 3
, paternally-expressed gene 3 protein-like
, Kruppel-type zinc finger protein
, paternally-expressed gene 3 protein
, zinc finger and SCAN domain-containing protein 24
, paternally expressed gene 3
, zinc-finger protein
, granule cell antiserum positive 4