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In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Additionally we are shipping and many more products for this protein.
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Human Polyclonal PEG3 Primary Antibody for IF (p), IHC (p) - ABIN735653
Ge, Liang, Luo, Wei, Han, Schatten, Sun, Zhang: Diabetic uterus environment may play a key role in alterations of DNA methylation of several imprinted genes at mid-gestation in mice. in Reproductive biology and endocrinology : RB&E 2014
Show all 2 Pubmed References
Porcine skeletal muscle-derived PW1(pos)/Pax7 (show PAX7 Antibodies)(neg (show TMEM131 Antibodies)) interstitial cells are a source of stem/progenitor cells.
The PEG3 gene expression was not affected by day of pregnancy or breed.
For PEG3, pigs expressed the paternal allele in skeletal muscle, liver, spleen, kidney, and uterus, but biallele in heart, lung, fat, stomach, small intestine, and ovary.
Data suggest that PEG3 is required for TFEB (show TFEB Antibodies) induction and nuclear translocation in a VEGFR2 (show KDR Antibodies)- and AMPK (show PRKAA1 Antibodies)-dependent manner for decorin/decorin (show DCN Antibodies) receptor-evoked autophagy. (PEG3 = paternally expressed 3 protein; TFEB (show TFEB Antibodies) = transcription factor EB (show TFEB Antibodies); VEGFR2 (show KDR Antibodies) = vascular endothelial growth factor receptor-2 (show KDR Antibodies); AMPK (show PRKAA1 Antibodies) = AMP-activated protein kinase (show PRKAA2 Antibodies))
Peg3 transcriptionally modulates BECN1 (show BECN1 Antibodies) activity.
Data indicate that a set of cis (show CISH Antibodies)-regulatory motifs and corresponding trans factors that may be critical for the transcriptional regulation of the Peg3 (Paternally Expressed Gene 3) domain.
In the current study, the authors have identified three alternative promoters for mouse Peg3 and one alternative promoter for human PEG3.
A resident population of resident smooth muscle progenitor cells expressing PW1 was identified in pulmonary hypertension-associated vascular remodeling.
PW1/Peg3 function is essential for conferring proper mesoangioblast competence and it's level in human mesoangioblasts may serve as a biomarker to identify donor populations for therapeutic application in muscular dystrophies.
The PEG3-SCAN domain appears to constitute an assembly block, enabling PEG3 homo- or heterodimerization to control gene expression in a combinatorial fashion.
Genetic translocations involving PEG3 gene is associated with mesenchymal hamartoma of the liver.
we have unveiled a mechanism for a secreted proteoglycan (show Vcan Antibodies) in inducing Peg3, a master regulator of macroautophagy in endothelial cells
Results show that a five percent increase in DNA methylation (show HELLS Antibodies) of PEG3 is associated with a 1.6-fold increase invasive cervical cancer (ICC) risk.
the expression of PEG3 domain genes within the maternal placenta is not significantly affected by the MIMT1Del mutation and alterations in PEG3 domain gene expression on the fetal side
Data show that a 110 kb microdeletion in the maternally imprinted PEG3 domain that results in a loss of paternal MIMT1 expression and causes late term abortion and stillbirth.
Peg3 was seriously demethylated or showed aberrant methylation patterns in four aborted clones.
PEG3 imprinted domain of humans, cows, and mice contains differing numbers of differentially methylated regions (DMR (show WDR20 Antibodies)), but the PEG3-CpG island is the only DMR (show WDR20 Antibodies) that is conserved among these three species.
Data suggest that the upregulations of Myb (show MYB Antibodies) and Peg3 are likely the key anti-cancer events of EGCG in vivo.
Strand-specific CpG hemimethylation, a novel epigenetic modification functional for genomic imprinting, has been demonstrated for Peg3 gene.
Data show that complete removal of paternally expressed gene 3 (PEG3) resulted in up-regulation of male-specific lethal 1 (Msl1 (show OPRK1 Antibodies)) and male-specific lethal 3 (Msl3 (show MSL3 Antibodies)).
orientation of the Peg3-ICR may play no role in its allele-specific DNA methylation (show HELLS Antibodies)
The results indicate that PW1 is a co-regulator of the beta cell cycle and can thus be considered a novel therapeutic target in diabetes.
This study demonstrated the existence of a novel population of resident adult cardiac stem cells expressing PW1(+) and their involvement in fibrotic remodeling after MI.
promoters of Peg3 derive sexually biased and tissue-specific expression patterns
Our study also identified the imprinting control region (ICR) of H19 (show NCKAP1 Antibodies) as a genomic target. According to the results, PEG3 binds to a specific sequence motif located between the 3(rd) and 4(th) CTCF (show CTCF Antibodies) binding sites of the H19 (show NCKAP1 Antibodies)-ICR. PEG3 also binds to the active maternal allele of the H19 (show NCKAP1 Antibodies)-ICR.
These results support a general role for Pw1/Peg3 in the regulation of body growth but not maternal care and lactation.
In human, ZIM2 and PEG3 are treated as two distinct genes though they share multiple 5' exons and a common promoter and both genes are paternally expressed (PMID:15203203). Alternative splicing events connect their shared 5' exons either with the remaining 4 exons unique to ZIM2, or with the remaining 2 exons unique to PEG3. In contrast, in other mammals ZIM2 does not undergo imprinting and, in mouse, cow, and likely other mammals as well, the ZIM2 and PEG3 genes do not share exons. Human PEG3 protein belongs to the Kruppel C2H2-type zinc finger protein family. PEG3 may play a role in cell proliferation and p53-mediated apoptosis. PEG3 has also shown tumor suppressor activity and tumorigenesis in glioma and ovarian cells. Alternative splicing of this PEG3 gene results in multiple transcript variants encoding distinct isoforms.
paternally expressed 3
, paternally-expressed gene 3 protein-like
, Kruppel-type zinc finger protein
, paternally-expressed gene 3 protein
, zinc finger and SCAN domain-containing protein 24
, paternally expressed gene 3
, zinc-finger protein
, granule cell antiserum positive 4