Phosphatidylethanolamine N-Methyltransferase Proteins (PEMT)

Phosphatidylcholine (PC) is the most abundant mammalian phospholipid. Additionally we are shipping PEMT Antibodies (42) and PEMT Kits (6) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PEMT 10400 Q9UBM1
PEMT 18618  
Rat PEMT PEMT 25511 Q08388
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Top PEMT Proteins at

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days

PEMT Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

More Proteins for Phosphatidylethanolamine N-Methyltransferase (PEMT) Interaction Partners

Human Phosphatidylethanolamine N-Methyltransferase (PEMT) interaction partners

  1. In genotypic combination analysis considering PEMT -744GG/CHDH (show CHDH Proteins) +432GG/BHMT (show BHMT Proteins) +742GG as the reference combination, PEMT -744GC/CHDH (show CHDH Proteins) +432GG/BHMT (show BHMT Proteins) +742GG genotypic combination was significantly higher in mothers of a down syndrome child compared with that in control mothers with an odds ratio of 2.061 (95% CI: 1.10-3.86, P=0.0342).

  2. Results showed that PEMT mRNA expression in liver tissues of non-alcoholic steatohepatitis (NASH) patients was significantly lower than those with simple steatosis suggesting a distinct clinical entity of lean NASH with insufficiency of PEMT activities.

  3. a significant association between the PEMT rs7946 A-allele and a risk of nonalcoholic fatty liver disease, with the effect being more prominent in East-Asians, but not in non-Asians (Meta-Analysis)

  4. Data show that phosphatidylethanolamineN-methyltransferase (PEMT) rs12325817 polymorphism only marginally changed the association value with academic achievement.

  5. Data suggest that maternal dietary intake during lactation (here, choline intake exceeding dietary recommendations) can alter hepatic PEMT activity and increase choline content of breast milk.

  6. MTHFR rs1801131 C allele and PEMT rs4646356 T allele were associated with a high risk of type 2 diabetes in Han Chinese.

  7. The GG genotype of the PEMT G774C polymorphism, higher levels of serum homocysteine and lower levels of serum betaine are associated with an increased risk of microangiopathy in patients with diabetes.

  8. PEMT is a functional single nucleotide polymorphism (rs7946) in PEMT with sporadic Alzheimer's disease risk in a Han Chinese population.

  9. the PEMT -774G>C and CHDH (show CHDH Proteins) +432G>T polymorphisms were associated with sperm concentration. This finding suggests a possible influence of these genes on sperm quality

  10. genetic association studies on endometriosis in a population of women in Poland: Data suggest interaction between an SNP in PEMT (rs4244593) and an SNP in MTHFR (show MTHFR Proteins) (Ala222Val; rs1801133) in infertile women with some indication of endometriosis.

Mouse (Murine) Phosphatidylethanolamine N-Methyltransferase (PEMT) interaction partners

  1. fenofibrate partially reversed hepatic steatosis and fibrosis in Pemt(-/-) mice when treatment was initiated after nonalcoholic fatty liver disease (NAFLD) had already been established. Increasing hepatic fatty acid oxidation can compensate for the lower VLDL-triacylglycerol secretion rate and prevent/reverse fatty liver disease in mice lacking PEMT.

  2. Results show that hepatic PEMT protein levels and activity are post-translationally repressed in homocystinuria and correlates with decreased phosphatidylcholine (show SGMS2 Proteins).

  3. Activation of PPARgamma (show PPARG Proteins) using pioglitazone in high fat diet-fed Pemt(-/-) mice improved liver function, while these mice were still protected against diet-induced obesity and insulin (show INS Proteins) resistance.

  4. Results showed that Pemt deficiency and high-fat diet in mouse model demonstrated the phenotypes resemble to the clinical features of the patients with lean non-alcoholic steatohepatitis.

  5. propose that cold-induced hypothermia in HF-fed Pemt(-/-) mice is linked to plasma hypoglycemia due to compromised hepatic glucose production.

  6. Lack of PEMT in mice does not promote fatty acid oxidation in skeletal muscle.

  7. Decreased lipogenesis in white adipose tissue may contribute to the resistance to diet-induced obesity in Pemt(-/-) mice.

  8. these findings indicate that the inhibition of Pemt activity ameliorates the ER stress associated with diabetic nephropathy in a model of type 1 diabetes

  9. This study evaluated the role of the role of phosphatidylethanolamine N-methyltransferase in hepatic carbohydrate metabolism in chow-fed mice.

  10. Pemt deficiency results in attenuated secretion of very low-density lipoproteins and homocysteine as well as in increased susceptibility to nonalcoholic liver disease.

PEMT Protein Profile

Protein Summary

Phosphatidylcholine (PC) is the most abundant mammalian phospholipid. This gene encodes an enzyme which converts phosphatidylethanolamine to phosphatidylcholine by sequential methylation in the liver. Another distinct synthetic pathway in nucleated cells converts intracellular choline to phosphatidylcholine by a three-step process. The protein isoforms encoded by this gene localize to the endoplasmic reticulum and mitochondria-associated membranes. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with PEMT

  • phosphatidylethanolamine N-methyltransferase (pemt)
  • phosphatidylethanolamine N-methyltransferase (MCA3065)
  • phosphatidylethanolamine N-methyltransferase (pmtA)
  • phosphatidylethanolamine N-methyltransferase (CNG04250)
  • phosphatidylethanolamine N-methyltransferase (pemtA)
  • phosphatidylethanolamine N-methyltransferase (pemtB)
  • phosphatidylethanolamine N-methyltransferase (PEMT)
  • phosphatidylethanolamine N-methyltransferase (Pemt)
  • AI255394 protein
  • DDBDRAFT_0204815 protein
  • DDBDRAFT_0219474 protein
  • DDBDRAFT_0267052 protein
  • DDBDRAFT_0267053 protein
  • DDB_0204815 protein
  • DDB_0219474 protein
  • DDB_0267052 protein
  • DDB_0267053 protein
  • PEAMT protein
  • Pempt protein
  • Pempt2 protein
  • PEMT2 protein
  • PHOMETH protein
  • PNMT protein
  • zgc:55479 protein

Protein level used designations for PEMT

phosphatidylethanolamine N-methyltransferase , phospholipid methyltransferase family protein , PEAMT , PEMT2

393127 Danio rerio
3103781 Methylococcus capsulatus str. Bath
3196945 Ruegeria pomeroyi DSS-3
3258746 Cryptococcus neoformans var. neoformans JEC21
8623635 Dictyostelium discoideum AX4
8627247 Dictyostelium discoideum AX4
10400 Homo sapiens
18618 Mus musculus
25511 Rattus norvegicus
360197 Bos taurus
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