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6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Additionally we are shipping PGD Proteins (24) and PGD Kits (6) and many more products for this protein.
Showing 10 out of 81 products:
Human Polyclonal PGD Primary Antibody for ICC, IF - ABIN441587
Elf, Lin, Xia, Pan, Shan, Wu, Lonial, Gaddh, Arellano, Khoury, Khuri, Lee, Boggon, Fan, Chen: Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin. in Oncogene 2016
Show all 2 Pubmed References
These results indicate that the PHGDH (show PHGDH Antibodies) gene expression, dictated by IL-2R signaling, is a crucial event for DNA synthesis during S phase of activated T cells.
Using transgenic mice expressing enhanced GFP under the Srr (show SRR Antibodies) promoter and mice with targeted deletion of Srr (show SRR Antibodies) or 3-Phosphoglycerate dehydrogenase (show PHGDH Antibodies), we demonstrate predominantly neuronal sources of d-serine dependent on astrocytic supply of l-serine.
Elevated levels of 4E-BP1 (show EIF4EBP1 Antibodies) may be involved in a mechanism to arrest brain development in Phgdh (show PHGDH Antibodies) knock out embryos.
Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence
Phgdh (show PHGDH Antibodies) deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of brain D-serine, an N-methyl-D-aspartate receptor (show GRIN1 Antibodies) co-agonist
Data suggest expression of Phgdh (show PHGDH Antibodies) in endometrium is regulated by Hoxa10 (show HOXA10 Antibodies).
Taken together, these data suggest that ADD1/SREBP1c (show SREBF1 Antibodies) is a key transcription factor for 6PGDH gene expression and would coordinate glucose metabolism and lipogenesis for energy homeostasis.
the Phgdh (show PHGDH Antibodies)-dependent phosphorylated pathway is essential for normal embryonic development, especially for brain morphogenesis
the presence of cis (show CISH Antibodies)-acting elements confer the cell type specificity of Phgdh (show PHGDH Antibodies) transcription in the distal promoter region.
The mouse Phgdh (show PHGDH Antibodies) gene spans approximately 27 kilobases in length and comprises 12 exons with 11 intervening introns and is mapped to chromosome 3, region F2-F3 by FISH.
Studies indicate link between the 6-phosphogluconate dehydrogenase, oxidative pentose phosphate pathway (PPP) and lipogenesis through Ru-5-P-dependent inhibition of serine/threonine protein kinase LKB1 (show STK11 Antibodies)-AMPK (show PRKAA1 Antibodies) signalling.
copy number gain of the PGD gene was consistently identified in cervical cancers but not in the normal tissues
Results show that 6PGD activity is upregulated with increased lysine acetylation in primary leukemia cells from human patients, providing mechanistic insights into 6PGD upregulation in cancer cells.
Expression of 6PGD positively correlates with advancing stage of lung carcinoma. Knockdown of 6PGD by shRNA potently inhibits c-Met tyrosine phosphorylation.
Data suggest that the affinity of Nox2 (show CYBB Antibodies) for NADPH (show NQO1 Antibodies) is increased in the presence of 6PGDH on cell stimulation.
Hsa (show CD24 Antibodies)-miR (show MLXIP Antibodies)-132 and -212 were negatively correlated with PGD in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders.
6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies.
, 6-phosphogluconate dehydrogenase
, NADP-6 phosphogluconate dehydrogenase
, phosphogluconate dehydrogenase
, 6-phosphogluconate dehydrogenase, decarboxylating
, 3-phosphoglycerate dehyrogenase
, D-3-phosphoglycerate dehydrogenase
, 6-phosphogluconate dehydrogenase (decarboxylating)