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6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Additionally we are shipping PGD Antibodies (81) and PGD Proteins (19) and many more products for this protein.
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Studies indicate link between the 6-phosphogluconate dehydrogenase, oxidative pentose phosphate pathway (PPP) and lipogenesis through Ru-5-P-dependent inhibition of serine/threonine protein kinase LKB1 (show STK11 ELISA Kits)-AMPK (show PRKAA1 ELISA Kits) signalling.
copy number gain of the PGD gene was consistently identified in cervical cancers but not in the normal tissues
Results show that 6PGD activity is upregulated with increased lysine acetylation in primary leukemia cells from human patients, providing mechanistic insights into 6PGD upregulation in cancer cells.
Expression of 6PGD positively correlates with advancing stage of lung carcinoma. Knockdown of 6PGD by shRNA potently inhibits c-Met tyrosine phosphorylation.
Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence
Data suggest that the affinity of Nox2 (show CYBB ELISA Kits) for NADPH (show NQO1 ELISA Kits) is increased in the presence of 6PGDH on cell stimulation.
Hsa (show CD24 ELISA Kits)-miR (show MLXIP ELISA Kits)-132 and -212 were negatively correlated with PGD in the prefrontal cortex of individuals affected with schizophrenia and bipolar disorders.
These results indicate that the PHGDH (show PHGDH ELISA Kits) gene expression, dictated by IL-2R signaling, is a crucial event for DNA synthesis during S phase of activated T cells.
Using transgenic mice expressing enhanced GFP under the Srr (show SRR ELISA Kits) promoter and mice with targeted deletion of Srr (show SRR ELISA Kits) or 3-Phosphoglycerate dehydrogenase (show PHGDH ELISA Kits), we demonstrate predominantly neuronal sources of d-serine dependent on astrocytic supply of l-serine.
Elevated levels of 4E-BP1 (show EIF4EBP1 ELISA Kits) may be involved in a mechanism to arrest brain development in Phgdh (show PHGDH ELISA Kits) knock out embryos.
Phgdh (show PHGDH ELISA Kits) deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of brain D-serine, an N-methyl-D-aspartate receptor (show GRIN1 ELISA Kits) co-agonist
Data suggest expression of Phgdh (show PHGDH ELISA Kits) in endometrium is regulated by Hoxa10 (show HOXA10 ELISA Kits).
Taken together, these data suggest that ADD1/SREBP1c (show SREBF1 ELISA Kits) is a key transcription factor for 6PGDH gene expression and would coordinate glucose metabolism and lipogenesis for energy homeostasis.
the Phgdh (show PHGDH ELISA Kits)-dependent phosphorylated pathway is essential for normal embryonic development, especially for brain morphogenesis
the presence of cis (show CISH ELISA Kits)-acting elements confer the cell type specificity of Phgdh (show PHGDH ELISA Kits) transcription in the distal promoter region.
The mouse Phgdh (show PHGDH ELISA Kits) gene spans approximately 27 kilobases in length and comprises 12 exons with 11 intervening introns and is mapped to chromosome 3, region F2-F3 by FISH.
6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two enzymopathies.
6-phosphogluconate dehydrogenase, decarboxylating
, 6-phosphogluconate dehydrogenase
, NADP-6 phosphogluconate dehydrogenase
, phosphogluconate dehydrogenase
, 6-phosphogluconate dehydrogenase (decarboxylating)
, 3-phosphoglycerate dehyrogenase
, D-3-phosphoglycerate dehydrogenase
, 6-phosphogluconate dehydrogenase, decarboxylating-like