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Phosphoribosyl Pyrophosphate Amidotransferase Proteins (PPAT)

The protein encoded by PPAT is a member of the purine/pyrimidine phosphoribosyltransferase family. Additionally we are shipping PPAT Antibodies (64) and PPAT Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PPAT 5471 Q06203
PPAT 117544 P35433
Mouse PPAT PPAT 231327  
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Top PPAT Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$3,415.50
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,437.50
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PPAT Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Rat (Rattus)

More Proteins for Phosphoribosyl Pyrophosphate Amidotransferase (PPAT) Interaction Partners

Fruit Fly (Drosophila melanogaster) Phosphoribosyl Pyrophosphate Amidotransferase (PPAT) interaction partners

  1. DREF (show ZBED1 Proteins) binds directly upstream of Prat and the DRE (show SUFUH Proteins) sites associated with its activity are necessary for Prat expression

  2. Data show the presence of apoptosis at the cellular level in both ade2 (show PAICS Proteins) and Prat mutants, and the upregulated gene HtrA2 (show HTRA2 Proteins), which encodes an apoptosis effector and is thus a candidate for initiating apoptosis in response to purine depletion.

  3. whereas Mod(Prat:bw)3-5 suppresses Prat in all stages and tissues examined for both sexes.

  4. Evidence suggests that Prat originated by gene duplication by retrotransposition of Prat2.

  5. Regulation of expression of prat in the adult eye was studied.

  6. Use of Prat and Prat2 double RNA interference causes more severe pupal lethal phenotypes and suggests that Prat and Prat2 have partially additive functions during Drosophila metamorphosis.

  7. Data show that the requirement for both Prat and Prat2 in Drosophila is not simply due to differences in protein function. Both genes have developed nonoverlapping patterns of expression, which correlate with their respective loss-of-function phenotypes.

Human Phosphoribosyl Pyrophosphate Amidotransferase (PPAT) interaction partners

  1. purine biosynthetic pathway enzymes PPAT and PAICS, as well as pyruvate kinase activity are increased in lung cancer

PPAT Protein Profile

Protein Summary

The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. It is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosythetic pathway. This gene and PAICS/AIRC gene, a bifunctional enzyme catalyzing steps six and seven of this pathway, are located in close proximity on chromosome 4, and divergently transcribed from an intergenic region.

Gene names and symbols associated with PPAT

  • Phosphoribosylamidotransferase (Prat)
  • phosphoribosyl pyrophosphate amidotransferase (LOC100220341)
  • phosphoribosyl pyrophosphate amidotransferase (LOC100223932)
  • phosphoribosyl pyrophosphate amidotransferase (LOC100348590)
  • phosphoribosyl pyrophosphate amidotransferase (PPAT)
  • phosphoribosyl pyrophosphate amidotransferase (ppat)
  • phosphoribosyl pyrophosphate amidotransferase (Ppat)
  • 5730454C12Rik protein
  • AA408689 protein
  • AA675351 protein
  • AI507113 protein
  • Atase protein
  • C79945 protein
  • CG2867 protein
  • Dmel\\CG2867 protein
  • DmPrat protein
  • GPAT protein
  • PRAT protein

Protein level used designations for PPAT

CG2867-PA , CG2867-PB , Prat-PA , Prat-PB , phosphoribosylamidotransferase , transcript D , phosphoribosyl pyrophosphate amidotransferase , amidophosphoribosyltransferase-like , amidophosphoribosyltransferase , glutamine PRPP amidotransferase , glutamine phosphoribosylpyrophosphatate amidotransferase , glutamine phosphoribosylpyrophosphate amidotransferase , GPAT , ATase

GENE ID SPECIES
40935 Drosophila melanogaster
100220341 Taeniopygia guttata
100223932 Taeniopygia guttata
100348590 Oryctolagus cuniculus
100415443 Callithrix jacchus
398956 Xenopus laevis
5471 Homo sapiens
611407 Canis lupus familiaris
509652 Bos taurus
117544 Rattus norvegicus
231327 Mus musculus
422743 Gallus gallus
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