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The protein encoded by PIM1 belongs to the Ser/Thr protein kinase family, and PIM subfamily. Additionally we are shipping PIM1 Kits (33) and PIM1 Proteins (19) and many more products for this protein.
Showing 10 out of 179 products:
Human Polyclonal PIM1 Primary Antibody for EIA, IHC (p) - ABIN360328
Pasqualucci, Neumeister, Goossens, Nanjangud, Chaganti, Küppers, Dalla-Favera: Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas. in Nature 2001
Show all 5 references for ABIN360328
Human Polyclonal PIM1 Primary Antibody for IHC (p), WB - ABIN392440
Wallentine, Kim, Seiler, Vaughn, Crockett, Tripp, Elenitoba-Johnson, Lim: Comprehensive identification of proteins in Hodgkin lymphoma-derived Reed-Sternberg cells by LC-MS/MS. in Laboratory investigation; a journal of technical methods and pathology 2007
Show all 5 references for ABIN392440
Human Polyclonal PIM1 Primary Antibody for IHC (p), WB - ABIN392441
Baron, Anastasi, Hyjek, Bies, Reddy, Dong, Joseph, Thirman, Wroblewski, Wolff, Baron: PIM1 gene cooperates with human BCL6 gene to promote the development of lymphomas. in Proceedings of the National Academy of Sciences of the United States of America 2012
Human Polyclonal PIM1 Primary Antibody for ELISA, WB - ABIN1532475
Selten, Cuypers, Boelens, Robanus-Maandag, Verbeek, Domen, van Beveren, Berns: The primary structure of the putative oncogene pim-1 shows extensive homology with protein kinases. in Cell 1986
Cow (Bovine) Polyclonal PIM1 Primary Antibody for WB - ABIN2786676
Wernig, Gonneville, Crowley, Rodrigues, Reddy, Hudon, Walz, Reiter, Podar, Royer, Constantinescu, Tomasson, Griffin, Gilliland, Sattler: The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes. in Blood 2008
Human Polyclonal PIM1 Primary Antibody for EIA, IHC (p) - ABIN360327
Chen, Kobayashi, Darmanin, Qiao, Gully, Zhao, Kondo, Wang, Wang, Yeung, Lee: Hypoxia-mediated up-regulation of Pim-1 contributes to solid tumor formation. in The American journal of pathology 2009
Inhibition of the Pim1 oncogene (show RAB1A Antibodies) results in diminished visual function.
Data suggest that combining PIM and JAK2 (show JAK2 Antibodies) kinase inhibitors may offer a more efficacious therapeutic approach for myeloproliferative neoplasms (MPNs) over JAK2 (show JAK2 Antibodies) inhibitor mono-therapy.
A high percentage of urothelial carcinomas express Pim kinases. Pim expression differs in NILG, NIHG, and IHG lesions.
Mutations of Lon (show LONP1 Antibodies), which likely impair its chaperone properties, are at the basis of a genetic inherited disease named the cerebral, ocular, dental, auricular, skeletal (CODAS) syndrome. (Review)
Downregulation of microRNA33a promotes the expression CDK6 (show CDK6 Antibodies), CCND1 (show CCND1 Antibodies), and PIM1, and gastric cancer cell proliferation.
glycogen synthase kinase 3 beta (GSK3B (show GSK3b Antibodies)) and the forkhead box P3 (FOXP3 (show FOXP3 Antibodies)) transcription factors are direct PIM1 targets.
Inhibition of Lon (show LONP1 Antibodies) protease by triterpenoids alters mitochondria and is associated to cell death in human cancer cells.
By associating with PIM-1L, CD180 (show CD180 Antibodies) can thus obtain autonomous signaling capabilities, and this complex is then channeling inflammatory signals into B cell survival programs
Pim1 kinase activity maintains airway epithelial integrity and protects against house dust mite-induced proinflammatory activation of the airway epithelium.
Pim-1 and Pim-3 (show PIM3 Antibodies) enhance phosphorylation and cell surface expression of CXCR4 (show CXCR4 Antibodies) in prostate cancer cells. PC-3 (show PCSK1 Antibodies) prostate cancer cells overexpressing either Pim-1 or Pim-3 (show PIM3 Antibodies) kinases form larger xenograft tumors than the parental PC-3 (show PCSK1 Antibodies) cells.
Lon (show LONP1 Antibodies) downregulation attenuated hypoxia-induced cardiomyocyte apoptosis through a reduction of reactive oxygen species level.
Pim kinases prevent premature cardiac aging and maintain a healthy pool of functional mitochondria leading to efficient cellular energetics.
Pim-1 kinase activity regulates hepatocyte growth factor (show HGF Antibodies)-induced tumor cell migration, invasion, and cell scattering.
these results identify Pim1 as a novel effector molecule sufficient to drive CD4 (show CD4 Antibodies)( ) alphabeta T-cell development and survival in the absence of gammac cytokine receptor (show LEPR Antibodies) signaling.
Our data suggest that Pim1 might contribute to progression rather than initiation in prostate neoplasia.
Loss of PIM1 is associated with abnormal hematopoietic phenotypes.
Pim-1 activity prevents Drp1 (show CRMP1 Antibodies) compartmentalization to the mitochondria and preserves reticular mitochondrial morphology in response to sI
Pim1 kinase deletion and inhibition slows endothelial cell detachment by trypsinization and increases cell adhesion.
Telomere elongation consistent with a young phenotype is observed following Pim-1 overexpression.
demonstrated that over-expression of miR-16 (show GDE1 Antibodies) mimics suppressed Pim-1 expression in FD-FLT3 (show FLT3 Antibodies)/ITD cells suggesting that increased miR-16 (show GDE1 Antibodies) expression contributes to depletion of Pim-1 after FLT3 (show FLT3 Antibodies) inhibition
The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons (PMIDs:16186805, 1825810).
proto-oncogene serine/threonine-protein kinase pim-1
, kinase pim-1
, proviral integration site 2
, serine/threonine-protein kinase Pim-1
, serine/threonine-protein kinase pim-2
, pim-1 oncogene
, hLON ATP-dependent protease
, lon protease homolog, mitochondrial
, mitochondrial ATP-dependent protease Lon
, mitochondrial lon protease-like protein
, serine protease 15
, Oncogene PIM1
, pim-1 kinase 44 kDa isoform
, pim-1 oncogene (proviral integration site 1)
, serine/threonine-protein kinase pim-1
, non-specific serine/threonine protein kinase
, proto-oncogene serine/threonine-protein kinase Pim-1
, proviral integration site 1