Pituitary Tumor-Transforming 1 Proteins (PTTG1)

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. Additionally we are shipping PTTG1 Antibodies (78) and PTTG1 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PTTG1 9232 O95997
PTTG1 64193 P97613
PTTG1 30939 Q9CQJ7
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Top PTTG1 Proteins at antibodies-online.com

Showing 10 out of 15 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 15 to 19 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
Yeast Wild boar His tag   1 mg Log in to see 60 to 71 Days
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
Yeast Pan troglodytes His tag   1 mg Log in to see 60 to 71 Days
Yeast Schizosaccharomyces pombe His tag   1 mg Log in to see 60 to 71 Days

PTTG1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, , ,
Rat (Rattus)

Mouse (Murine) ,

Top referenced PTTG1 Proteins

  1. Human PTTG1 Protein expressed in Escherichia coli (E. coli) - ABIN666649 : Chien, Pei: A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product. in The Journal of biological chemistry 2000 (PubMed)
    Show all 2 references for 666649

More Proteins for Pituitary Tumor-Transforming 1 (PTTG1) Interaction Partners

Human Pituitary Tumor-Transforming 1 (PTTG1) interaction partners

  1. Findings indicate that PBF (show PTTG1IP Proteins) and PTTG have a critical role in promoting thyroid cancer that is predictive of poorer patient outcome.

  2. PTTG-mediated FGF2 (show FGF2 Proteins) upregulation is associated with more aggressive tumor features in patients with acromegaly. Also, locally produced estrogen through aromatization might have a role in this phenomenon.

  3. All these suggest that the MAP3K M1P site is a potential interacting partner of MAP3K SH3 domain, which may mediate the intermolecular recognition between hPTTG1 and MAP3K.

  4. that PTTG1 is a novel downstream target gene of androgen receptor (show AR Proteins) and take part in prostate cancer proliferation and metastasis

  5. Knockdown of PTTG1 suppresses the growth and invasion of LAC (show LCT Proteins) cells through upregulation of the TGFbeta1 (show TGFB1 Proteins)/SMAD3 (show SMAD3 Proteins) signaling.

  6. PTTG1 is correlated with non-small cell lung cancer (NSCLC) progression and as an independent poor prognostic factor in NSCLC patients.

  7. Our data indicate that securin expression may serve as a strong and independent prognosticator of breast cancer outcome

  8. PTTG1 mRNA expression levels in gastric tumor tissues were significantly higher than in the corresponding adjacent normal gastric mucosa.PTTG1 mRNA and protein expression are independent prognostic factors for gastric cancer patient survival.

  9. Pttg1 may increase BC cell growth through nuclear exclusion of p27 (show PAK2 Proteins), which highlights a novel molecular regulatory machinery in tumorigenesis of BC.

  10. Data show that overexpression of c-myc proto-oncogene (show MYC Proteins) protein (show MYC Proteins) could prevent the metabolic shift induced by pituitary tumor-transforming gene (PTTG) knockwown.

Pig (Porcine) Pituitary Tumor-Transforming 1 (PTTG1) interaction partners

  1. PTTG1 is a new candidate maternal effect gene that may participate in the processes of oocyte maturation and zygotic genome activation during embryogenesis

Mouse (Murine) Pituitary Tumor-Transforming 1 (PTTG1) interaction partners

  1. High PTTG1 expression is associated with pituitary tumor development.

  2. PTTG is functionally required for hepatic fibrosis progression in an animal model of chronic liver injury, and thus a potential treatment target.

  3. RasGrf1 (show RASGRF1 Proteins) is an important upstream component of signal transduction pathways regulating Pttg1 expression and controlling beta cell development and physiological responses.

  4. these results implicate Pttg1 in the regulation of homotypic spacing between specific types of retinal neurons.

  5. Pttg1/securin has roles in branching morphogenesis of the mammary gland and suppression of mammary tumorigenesis

  6. PBF (show PTTG1IP Proteins) is the first protein to interact with the critical TH transporter MCT8 (show MCT8 Proteins) and modulate its function in vivo

  7. CSN3 (show CSN3 Proteins) and CSN5 (show COPS5 Proteins) are involved in oocyte meiosis by regulating degradation of Cyclin B1 (show CCNB1 Proteins) and Securin via APC (show APC Proteins)/C.

  8. The genetically deleting Tff3 (show TFF3 Proteins) in mice altered down-regulated Pttg1 and up-regulated serpina3n (show SERPINA3N Proteins) expression, indicating a potential role of these factors during the development of presbyacusis.

  9. data reveal that up to 9 months of age, Pttg1(-/-) retinas have a healthy morphology and normal photoreceptor function

  10. Pituitary tumor transforming gene 1 (PTTG1), an oncogene (show RAB1A Proteins), was the most up-regulated transcript in KLF6 (show KLF6 Proteins)+/- liver. PTTG1 downregulation represents a novel tumor suppressor pathway of KLF6 (show KLF6 Proteins).

PTTG1 Protein Profile

Protein Summary

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.

Gene names and symbols associated with PTTG1

  • pituitary tumor-transforming 1 (PTTG1)
  • pituitary tumor-transforming 1 (Pttg1)
  • pituitary tumor-transforming gene 1 (Pttg1)
  • AW555095 protein
  • C87862 protein
  • EAP1 protein
  • HPTTG protein
  • Pttg protein
  • PTTG1 protein
  • Pttg3 protein
  • Securin protein
  • TUTR1 protein

Protein level used designations for PTTG1

pituitary tumor-transforming protein 1 , securin , pituitary tumor-transforming 1 , ESP1-associated protein 1 , pituitary tumor-transforming gene 1 protein , tumor-transforming protein 1 , Pituitary tumor transforming

416158 Gallus gallus
479307 Canis lupus familiaris
510673 Bos taurus
539883 Bos taurus
696143 Macaca mulatta
9232 Homo sapiens
64193 Rattus norvegicus
397015 Sus scrofa
508043 Bos taurus
462238 Pan troglodytes
30939 Mus musculus
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