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PLEKHA1 encodes a pleckstrin homology domain-containing adapter protein. Additionally we are shipping PLEKHA1 Proteins (7) and many more products for this protein.
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Studies indicate that the high-risk allele of the 10q26 locus encompasses three genes, PLEKHA1, ARMS2 (show ARMS2 Antibodies), and HTRA1 (show HTRA1 Antibodies) with high linkage disequilibrium.
CX3CR1 (show CX3CR1 Antibodies) (T280M and V249I) and PLEKHA1 (A320T) polymorphisms were not found to be associated with age-related macular degeneration in an Indian population.
This study provides evidence of the joint contribution of genetic variants in PLEKHA1/ARMS2 (show ARMS2 Antibodies)/HTRA1 (show HTRA1 Antibodies) to age-related macular degeneration risk.
TAPP1 binds to protein tyrosine phosphatase PTPL1 (show PTPN13 Antibodies).
syntrophins regulate the localization of TAPP1, which may be important for remodeling the actin cytoskeleton in response to growth factor stimulation
PLEKHA1 is strongly implicated as primarily responsible for the evidence of linkage of age-related maculopathy (ARM) to the 10q26 locus and as a major contributor to ARM.susceptibility.
Although a role for PLEKHA1 could not be totally excluded, there was a four times higher age-related macular degeneration risk was associated with haplotype "A-T-A" involving "PLEKHA1-LOC387715-HTRA1 (show HTRA1 Antibodies)" risk alleles.
Independent of CFH (show CFH Antibodies) genotype or smoking history, an individual's risk of AMD (show AMD1 Antibodies) (age-related macular degeneration) could be increased or decreased, depending on their genotype or haplotype in the 10q26 region.
Results identify TAPP1 as an important negative regulator of oligodendrocyte precursor cells differentiation through the Mek (show MDK Antibodies)/Erk (show EPHB2 Antibodies) signaling pathway.
interacts with phosphatidylinositol (3,4)-bisphosphate thus regulating B-cell activation (show BLNK Antibodies) and autoantibody production
This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.
pleckstrin homology domain-containing family A member 1
, pleckstrin homology domain-containing protein family A member 1
, tandem PH domain containing protein-1
, pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
, tandem PH domain-containing protein 1
, PH domain-containing family A member 1