Pleckstrin Homology Domain Containing, Family O Member 1 Proteins (PLEKHO1)

Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). Additionally we are shipping Pleckstrin Homology Domain Containing, Family O Member 1 Antibodies (50) and Pleckstrin Homology Domain Containing, Family O Member 1 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PLEKHO1 51177 Q53GL0
PLEKHO1 67220 Q9JIY0
PLEKHO1 310674 Q5BJM5
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Top Pleckstrin Homology Domain Containing, Family O Member 1 Proteins at antibodies-online.com

Showing 7 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,131.33
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$3,135.00
Details
Yeast Chicken His tag   1 mg Log in to see 60 to 71 Days
$3,179.00
Details

PLEKHO1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

More Proteins for Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) Interaction Partners

Human Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) interaction partners

  1. the increased PLEKHO1 could suppress Smad-dependent BMP signaling to inhibit bone formation during aging.

  2. High expression levels of CKIP1 were associated with the development of lung cancer, and that CKIP1 knockdown may block tumor cell growth mainly by promoting cell apoptosis.

  3. New light on the molecular mechanism of cell adhesion-mediated drug resistance in Non-Hodgkin's Lymphoma (NHL) and targeting CKIP-1 may be a novel therapeutic target for NHL.

  4. There is a major role of the CK2alpha-interacting protein CKIP-1 in activation of PAK1 (show PAK1 Proteins) for neoplastic prostate cells transformation.

  5. CKIP-1 interacts with CARMA1 (show CARD11 Proteins) and has an inhibitory effect on PKCtheta (show PRKCQ Proteins);-CBM-NF-kappaB (show NFKB1 Proteins) signaling.

  6. CKIP-1 controlled Smurf1 (show SMURF1 Proteins) expression in colon cancer

  7. overexpression triggers classical monocyte activation and transactivation of the TNF (show TNF Proteins) promoter

  8. CKIP-1, through its leucine zipper, interacts with the Rpt6 and mediates the Smurf1 (show SMURF1 Proteins)-Rpt6 interaction.

  9. CKIP-1 is involved in various important signaling pathways, controlling cell growth, apoptosis, differentiation, cytoskeleton and bone formation--REVIEW

  10. The N-terminal PH domain and C-terminal auto-inhibitory region of CKIP-1 coordinate to determine its subcellular localization and the nucleus-plasma membrane shuttling.

Mouse (Murine) Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) interaction partners

  1. The results indicate that CKIP-1 deficiency in mice aggravates HFD-induced fatty liver by upregulating JNK1 (show MAPK8 Proteins) phosphorylation and further upregulating IRS-1 (show IRS1 Proteins) phosphorylation and RI.

  2. the increased PLEKHO1 could suppress Smad-dependent BMP signaling to inhibit bone formation during aging.

  3. Data suggest CKIP1 (casein kinase 2 interacting protein-1) plays role in resistance to oxidative stress in glomerular mesangial cells in development of diabetic nephropathy; mechanisms appear to include down-regulation of expression of ICAM1 (intercellular adhesion molecule-1 (show ICAM1 Proteins)) and fibronectin (show FN1 Proteins) plus activation of Nrf2 (show NFE2L2 Proteins)/ARE (nuclear factor E2-related factor 2/antioxidant response element) antioxidative stress pathway.

  4. the effect of CKIP-1 on the regulation of bone metabolism and osteogenesis

  5. CKIP-1 is a novel inhibitor of MSC (show MSC Proteins)-originated adipogenesis by enhancing HDAC1 (show HDAC1 Proteins)-associated repression of C/EBPalpha (show CEBPA Proteins).

  6. CKIP-1 interacts with TRAF6 (show TRAF6 Proteins), a ubiquitin ligase (show RNF123 Proteins) required for K63-linked ubiquitination and plasma membrane recruitment of Akt (show AKT1 Proteins), and terminates TRAF6 (show TRAF6 Proteins)-mediated Akt (show AKT1 Proteins) activation.

  7. Knockdown of CKIP-1 in RAW264.7 macrophage cells resulted in impaired cell migration.

  8. CKIP-1 was found to be an inhibitor of cardiac hypertrophy by upregulating the dephosphorylation of HDAC4 through the recruitment of protein phosphatase 2A.

  9. CKIP-1 has a role in cell morphology that depends on its interaction with actin-capping protein (show TMOD4 Proteins)

  10. CKIP-1 functions as the first auxiliary factor to enhance the activation of Smurf1 (show SMURF1 Proteins).

Pleckstrin Homology Domain Containing, Family O Member 1 (PLEKHO1) Protein Profile

Protein Summary

Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation (By similarity).

Gene names and symbols associated with PLEKHO1

  • pleckstrin homology domain containing, family O member 1 (PLEKHO1)
  • pleckstrin homology domain containing, family O member 1 (Plekho1)
  • 2810052M02Rik protein
  • CKIP-1 protein
  • Ckip1 protein
  • JZA-20 protein
  • Jza2 protein
  • OC120 protein
  • RGD1311487 protein

Protein level used designations for PLEKHO1

pleckstrin homology domain containing, family O member 1 , OC120 , 2810052M02Rik , C-Jun-binding protein , CK2 interacting protein 1; HQ0024c protein , CK2-interacting protein 1 , JBP , PH domain-containing family O member 1 , casein kinase 2-interacting protein 1 , osteoclast maturation-associated gene 120 protein , pleckstrin homology domain-containing family O member 1 , CK2 interacting protein 1 , Jun zipper-associated 2 , TNF intracellular domain-interacting protein

GENE ID SPECIES
457268 Pan troglodytes
607927 Canis lupus familiaris
706145 Macaca mulatta
100152184 Sus scrofa
100347162 Oryctolagus cuniculus
100444299 Pongo abelii
51177 Homo sapiens
67220 Mus musculus
310674 Rattus norvegicus
788251 Bos taurus
426108 Gallus gallus
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