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Polo-Like Kinase 4 Proteins (PLK4)

PLK4 encodes a member of the polo family of serine/threonine protein kinases. Additionally we are shipping Polo-Like Kinase 4 Antibodies (30) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PLK4 10733 O00444
PLK4 20873 Q64702
Rat PLK4 PLK4 310344  
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Top Polo-Like Kinase 4 Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) REACT_Bacteriophage 42D Un-conjugated   100 μg Log in to see 9 to 11 Days
$229.90
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details

PLK4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Polo-Like Kinase 4 (PLK4) Interaction Partners

Fruit Fly (Drosophila melanogaster) Polo-Like Kinase 4 (PLK4) interaction partners

  1. When Asl (show ADSL Proteins) reduction is attenuated by Asl (show ADSL Proteins) overexpression, plk4 mutations, Plk4 RNAi, or Slimb overexpression, Asl (show ADSL Proteins) levels are higher in spermatozoa, resulting in embryos with reduced viability.

  2. Drosophila Plk4 phosphorylates four conserved serines in the STAN motif of the core centriole protein Ana2 to enable it to bind and recruit its Sas6 (show SASS6 Proteins) partner.

  3. Plk4 directly generates its own phosphodegron.Phosphorylation of only S293 of the Slimb-recognition motif is required for Slimb binding to Plk4.

  4. Regulation of autophosphorylation controls PLK4 self-destruction and centriole number.PLK4 protein levels are controlled by Slimb.

  5. Data indicate that interphase centrioles are closely associated with Sas-4, Spd-2, Polo kinase, Pericentrin-like protein (Dplp), Asterless (Asl), Plk4 kinase, Centrosomin (Cnn) and gamma-tubulin.

  6. SAK/PLK4 is required for centriole duplication and flagella development.

Human Polo-Like Kinase 4 (PLK4) interaction partners

  1. Decreased PLK4 protein expression due to promoter hypermethylation was negatively correlated with JAK2 (show JAK2 Proteins) overexpression, a common occurrence in hematological malignancies.

  2. KLF14 transcription is signi (show SP6 Proteins)ficantly downregulated, whereas Plk4 transcription is upregulated in multiple types of cancers, and there exists an inverse correlation between KLF14 and Plk4 protein expression in human breast and colon cancers.

  3. The authors suggest that the STIL-coiled-coil region/PLK4 interaction mediates PLK4 activation as well as stabilization of centriolar PLK4 and plays a key role in centriole duplication.

  4. We demonstrate that centrioles promote PLK4 activation through its recruitment and local accumulation. Though centriole removal reduces the proportion of active PLK4, this is rescued by concentrating PLK4 to the peroxisome lumen

  5. these results identify the interaction between Mib1 and Plk4 as a new and important element in the control of centriole homeostasis.

  6. PLK4 functions downstream of ROCK2 (show ROCK2 Proteins) to drive centrosome amplification in arrested cells.

  7. PLK4 overexpression induces centrosome amplification and chromosome instability and causes the suppression of primary cilia formation (show PIFO Proteins).

  8. Negative feedback by centriolar STIL regulates bimodal centriolar distribution of Plk4 and seemingly restricts occurrence of procentriole formation to one site on each parental centriole.

  9. An unexpected activity of Plk4 that promotes cell migration and may underlie an association between increased Plk4 expression, cancer progression and death from metastasis in solid tumor patients.

  10. Plk4 activity promotes the recruitment of STIL to the centriole and primes the direct binding of STIL to the C terminus of SAS6 (show SASS6 Proteins).

Mouse (Murine) Polo-Like Kinase 4 (PLK4) interaction partners

  1. that aneuploidy induced by transient centrosome amplification can accelerate tumorigenesis in p53 (show TP53 Proteins)-deficient cells

  2. Transient knockdown of KLF14 (show SP6 Proteins) is sufficient to induce Plk4-directed centrosome amplification.

  3. PLK4 is essential for meiotic resumption but may not influence spindle formation in mouse oocytes during meiotic maturation

  4. p53-Dependent and cell specific epigenetic regulation of the polo-like kinases under oxidative stress.

  5. The Plk4-Cep152 complex has an unexpected role in promoting microtubule nucleation in the vicinity of chromosomes to mediate bipolar spindle formation in the absence of centrioles.

  6. Loss of Plk4 is associated with centrosome amplification causing microcephaly.

  7. PP2A (show PPP2R2B Proteins) (Protein Phosphatase 2A(Twins)) counteracts Plk4 autophosphorylation, thus stabilizing Plk4 and promoting centriole duplication

  8. the I242N heterozygous mutation in PLK4 is causative for patchy germ cell loss beginning at P10 (show NUTF2 Proteins), suggesting a role for PLK4 during the initiation of spermatogenesis.

  9. Aberrant Plk methylation is correlated with the development of hepatocellular carcinoma in mice.

  10. Plk4 is required for cytokinesis and maintenance of chromosomal stability

Zebrafish Polo-Like Kinase 4 (PLK4) interaction partners

  1. results provide the first steps in defining a new role for plk4 in organogenesis and implies a role in planar cell polarity, segmentation, and in recently described PLK4 mutations in human

Polo-Like Kinase 4 (PLK4) Protein Profile

Protein Summary

This gene encodes a member of the polo family of serine/threonine protein kinases. The protein localizes to centrioles, complex microtubule-based structures found in centrosomes, and regulates centriole duplication during the cell cycle. Three alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.

Gene names and symbols associated with Polo-Like Kinase 4 Proteins (PLK4)

  • Sak kinase (SAK)
  • polo-like kinase 4 (PLK4)
  • polo-like kinase 4 (Plk4)
  • polo-like kinase 4 (Drosophila) (plk4)
  • serine/threonine protein kinase (AaeL_AAEL009360)
  • 1700028H20 protein
  • AI385771 protein
  • CG7186 protein
  • Dmel\\CG7186 protein
  • DmSAK protein
  • PLK-4 protein
  • plk4 protein
  • SAK protein
  • SAK/PLK protein
  • SAK/PLK4 protein
  • stk18 protein
  • wu:fi33g07 protein

Protein level used designations for Polo-Like Kinase 4 Proteins (PLK4)

CG7186-PA , SAK-PA , PLK-4 , Snk akin kinase , serine/threonine kinase 18 , serine/threonine protein kinase SAK , serine/threonine-protein kinase 18 , serine/threonine-protein kinase PLK4 , serine/threonine-protein kinase Sak

GENE ID SPECIES
40384 Drosophila melanogaster
10733 Homo sapiens
20873 Mus musculus
310344 Rattus norvegicus
476087 Canis lupus familiaris
100517044 Sus scrofa
514405 Bos taurus
368390 Danio rerio
5571876 Aedes aegypti
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