Poly(A) Binding Protein, Cytoplasmic 1 Proteins (PABPC1)

PABPC1 encodes a poly(A) binding protein. Additionally we are shipping Poly(A) Binding Protein, Cytoplasmic 1 Antibodies (75) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PABPC1 26986 P11940
PABPC1 18458 P29341
PABPC1 171350 Q9EPH8
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Top Poly(A) Binding Protein, Cytoplasmic 1 Proteins at antibodies-online.com

Showing 7 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Escherichia coli (E. coli) Human His-SUMO Tag   50 μg Log in to see 11 Days
$341.00
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,840.83
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   250 μg Log in to see 2 to 3 Days
$777.50
Details

PABPC1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Mouse (Murine)

Rat (Rattus)

Top referenced Poly(A) Binding Protein, Cytoplasmic 1 Proteins

  1. Human PABPC1 Protein expressed in Wheat germ - ABIN1313849 : Massimelli, Majerciak, Kruhlak, Zheng: Interplay between polyadenylate-binding protein 1 and Kaposi's sarcoma-associated herpesvirus ORF57 in accumulation of polyadenylated nuclear RNA, a viral long noncoding RNA. in Journal of virology 2012 (PubMed)

More Proteins for Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1) Interaction Partners

Human Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1) interaction partners

  1. Data suggest that DEAD-box helicase 3 (DDX3X (show DDX3X Proteins)) physically interacts and co-localizes with poly(A)-binding cytoplasmic protein (show BLZF1 Proteins) 1 (PABPC1) and caprin-1 in lamellipodia at the leading edge of spreading cells; these interactions are dependent on mRNA; depletion of DDX3X (show DDX3X Proteins) (via gene silencing with the CRISPR-Cas (show CSE1L Proteins) system) leads to decreased cell motility. These studies were conducted using MRC5 lung fibroblast cell line.

  2. Data suggest that hnRNPLL (show HNRPLL Proteins) specifically associates with cytoplasmic PABPC1 in both T-lymphocytes and plasma cells; PABPC1 promotes binding of hnRNPLL (show HNRPLL Proteins) to immunoglobulin H (IgH, heavy chain) mRNA and regulates switching from mIgH (membrane isoform) to sIgH (secreted isoform) in plasma cells. (hnRNPLL (show HNRPLL Proteins) = heterogeneous nuclear ribonucleoprotein L-like (show HNRPLL Proteins) protein; PABPC1 = cytoplasmic poly[A]-binding protein 1)

  3. PABP enhances the productive binding of the eRF1 (show ZFP36L1 Proteins)-eRF3 complex to the ribosome, via interactions with the N-terminal domain of eRF3a (show GSPT1 Proteins) which itself has an active role in translation termination.

  4. Unr (show P2RY4 Proteins) stimulated the binding of PABP1 to mRNA, and that Unr (show P2RY4 Proteins) was required for the stable interaction of PABP1 and eIF4G (show EIF4G1 Proteins) in cells.

  5. PABPC1 decreased expression in in infertile men with non-obstructive azoospermia

  6. BTG2 (show BTG2 Proteins) stimulates mRNA deadenylation via CAF1 (show CHAF1B Proteins) activation through interaction with PABPC1. Interaction of BTG2 (show BTG2 Proteins) with the first RRM domain of PABPC1 is required for BTG2 (show BTG2 Proteins) to control cell proliferation.

  7. PABPC1 is a novel co-regulator of the AR

  8. PABPC1 is upregulated in gastric carcinoma tissues, and high PABPC1 expression predicts poor survival. PABPC1 regulates proliferation and transformation of gastric cancer cells in vitro and in vivo. PABPC1 knockdown induces apoptosis.

  9. PABPC1 interacts with AGO2 (show EIF2C2 Proteins) and is responsible for the microRNA mediated gene silencing in high grade hepatocellular carcinoma.

  10. Poly(A) binding protein 1 enhances cap-independent translation initiation of neurovirulence factor from avian herpesvirus

Mouse (Murine) Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1) interaction partners

  1. Data suggest that hnRNPLL (show HNRPLL Proteins) specifically associates with cytoplasmic PABPC1 in both T-lymphocytes and plasma cells; PABPC1 promotes binding of hnRNPLL (show HNRPLL Proteins) to immunoglobulin H (IgH, heavy chain) mRNA and regulates switching from mIgH (membrane isoform) to sIgH (secreted isoform) in plasma cells. (hnRNPLL (show HNRPLL Proteins) = heterogeneous nuclear ribonucleoprotein L-like (show HNRPLL Proteins) protein; PABPC1 = cytoplasmic poly[A]-binding protein 1)

  2. Superovulation with low or high doses of gonadotropins significantly altered Epab and Pabpc1 mRNA levels in GV oocytes, MII oocytes and 1- and 2-cell embryos compared with their respective controls. These changes most likely lead to variations in expression of EPAB- and PABPC1-regulated genes, which may adversely influence the quality of oocytes and early embryos retrieved using superovulation.

  3. Data (including data from studies in knockout mice) suggest that Epab (embryonic poly(A)-binding protein), which is oocyte specific, is required for ability of cumulus cells and granulosa cells to exhibit responsiveness to Egf/Egfr (show EGFR Proteins) signaling.

  4. Epab(-/-) oocytes are smaller in size, contain peripheral germinal vesicles, and are loosely associated with cumulus cells

  5. These findings suggest that EPAB may predominantly play roles in translational regulation of the mRNAs during early oogenesis and folliculogenesis, but PABPC1 most likely perform these roles in the later terms of ovarian development along with EPAB

  6. Epab is dispensable for mouse spermatogenesis and male fertility.

  7. We analyzed the expression of sperm-specific Akap3 and the potential regulatory factors of its protein synthesis during mouse spermiogenesis.

  8. Both Epab and Pabpc1 expression increase during early postnatal life and reach their peak at D32 testis.

  9. our data support the concept that expanded ATXN2 (show ATXN2 Proteins) undergoes progressive insolubility and affects PABPC1 by a toxic gain-of-function mechanism with tissue-specific effects, which may be partially alleviated by the induction of FBXW8 (show FBXW8 Proteins).

  10. EPAB is necessary for oogenesis, folliculogenesis and female fertility in mice.

Poly(A) Binding Protein, Cytoplasmic 1 (PABPC1) Protein Profile

Protein Summary

This gene encodes a poly(A) binding protein. The protein shuttles between the nucleus and cytoplasm and binds to the 3' poly(A) tail of eukaryotic messenger RNAs via RNA-recognition motifs. The binding of this protein to poly(A) promotes ribosome recruitment and translation initiation\; it is also required for poly(A) shortening which is the first step in mRNA decay. The gene is part of a small gene family including three protein-coding genes and several pseudogenes.

Gene names and symbols associated with PABPC1

  • poly(A) binding protein, cytoplasmic 1-like (pabpc1l)
  • poly(A) binding protein, cytoplasmic 1 (pabpc1)
  • poly(A) binding protein, cytoplasmic 1-like (PABPC1L)
  • poly A binding protein, cytoplasmic 1 a (pabpc1a)
  • poly(A) binding protein, cytoplasmic 1 (pabpc1-a)
  • poly(A) binding protein, cytoplasmic 1 (PABPC1)
  • poly(A) binding protein, cytoplasmic 1 (Pabpc1)
  • ePAB protein
  • fi20g03 protein
  • pab-2 protein
  • PAB1 protein
  • Pabp protein
  • Pabp1 protein
  • pabpc1 protein
  • PABPC2 protein
  • PabpI protein
  • Pabpl1 protein
  • wu:fb16a02 protein
  • wu:fi19b08 protein
  • wu:fi20g03 protein
  • wu:fj12d09 protein
  • wu:fj61f06 protein
  • zgc:55855 protein
  • zgc:109879 protein

Protein level used designations for PABPC1

polyadenylate-binding protein 1-like , poly(A) binding protein, cytoplasmic 1 , polyadenylate-binding protein 1 , PABP 1-A , PABP-1-A , PABP-A , cytoplasmic poly(A)-binding protein 1-A , poly(A)-binding protein 1-A , polyadenylate-binding protein 1-A , xPABP1-A , poly(A) binding protein, cytoplasmic 2 , PABP 1 , PABP-1 , poly(A)-binding protein 1 , poly A binding protein 1

GENE ID SPECIES
327625 Danio rerio
448595 Xenopus (Silurana) tropicalis
711882 Macaca mulatta
606498 Danio rerio
379896 Xenopus laevis
430997 Gallus gallus
26986 Homo sapiens
612751 Canis lupus familiaris
282296 Bos taurus
18458 Mus musculus
171350 Rattus norvegicus
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