anti-Polymerase I and Transcript Release Factor (PTRF) Antibodies

PTRF encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. Additionally we are shipping PTRF Kits (10) and PTRF Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
PTRF 284119 Q6NZI2
PTRF 19285 O54724
PTRF 287710  
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Top anti-PTRF Antibodies at antibodies-online.com

Showing 10 out of 59 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB <b>IHC Information: </b>Paraffin embedded mouse vessel and adipocytes (skeletal muscle) tissue, tested with an antibody dilution of 5 ug/ml. 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of anti-PTRF Antibody (N-term) Pab in A375 cell line lysates (35ug/lane). PTRF(arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with PTRF antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Western blot analysis of anti-PTRF Antibody (N-term) in A375 cell line lysates (35ug/lane). PTRF(arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-PTRF Antibody (N-term) (ABIN391621) in A375 cell line lysates (35 µg/lane). PTRF(arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with PTRF antibody (N-term) (ABIN391621), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IP, WB Western Blot and Immunoprecipitation: PTRF Antibody [ABIN253106] - Detection of Human and Mouse PTRF by Western Blot (h&m) and Immunoprecipitation (h). Samples: Whole cell lysate from HeLa (5, 15 and 50 mcg for WB, 1 mg for IP, 20% of IP loaded) and mouse NIH3T3 (M, 50 mcg) cells. Antibodies: Affinity purified rabbit anti-PTRF antibody ABIN253106 used for WB at 0.04 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 3 mcg/mg lysate. PTRF was also immunoprecipitated by rabbit anti-PTRF antibodies ABIN253104 and ABIN253105 which recognize upstream epitopes. Detection: Chemiluminescence with exposure times of 3 minutes (A) and 3 seconds (B). 0.1 mL Log in to see 7 to 9 Days
$486.94
Details
Human Rabbit Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$340.00
Details
Human Rabbit Un-conjugated IP Western Blot: PTRF Antibody [ABIN253105] - Detection of Human PTRF by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-PTRF antibody ABIN253105 used for IP at 3 mcg/mg lysate. PTRF was also immunoprecipitated by rabbit anti-PTRF antibodies ABIN253104 and ABIN253106, which recognize other epitopes. Detection: Chemiluminescence with exposure times of 3 seconds (A and B). 100 μL Log in to see 7 to 9 Days
$486.94
Details
Cow Rabbit Un-conjugated IHC (p), WB Mouse Vessel and Adipocytes: Formalin-Fixed, Paraffin-Embedded (FFPE) 100 μg Log in to see 7 to 9 Days
$595.83
Details
Human Rabbit Un-conjugated WB Western blot analysis of anti-PTRF Antibody (N-term) Pab (ABIN391622) in A375 cell line lysates (35 µg/lane). PTRF(arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: PTRF Antibody [NBP1-80220] - Sample Tissue: Mouse Lung Antibody Dilution: 1.0ug/ml Immunohistochemistry-Paraffin: PTRF Antibody [NBP1-80220] - Mouse vessel and adipocytes (skeletal muscle), 5 ug/ml. 100 μL Log in to see 8 to 11 Days
$408.19
Details

PTRF Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , , , ,
,
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Mouse (Murine)


Rat (Rattus)


Top referenced anti-PTRF Antibodies

  1. Human Polyclonal PTRF Primary Antibody for ELISA, ICC - ABIN4240533 : Hill, Bastiani, Luetterforst, Kirkham, Kirkham, Nixon, Walser, Abankwa, Oorschot, Martin, Hancock, Parton: PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function. in Cell 2008 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal PTRF Primary Antibody for IHC (p), WB - ABIN391621 : Park, Yamaura, Kawamoto, Kurihara, Sato: Reciprocal modulation of surface expression of annexin A2 in a human umbilical vein endothelial cell-derived cell line by eicosapentaenoic acid and docosahexaenoic acid. in PLoS ONE 2014 (PubMed)

  3. Human Polyclonal PTRF Primary Antibody for IP - ABIN253105 : Dávalos, Fernández-Hernando, Sowa, Derakhshan, Lin, Lee, Zhao, Luo, Colangelo, Sessa: Quantitative proteomics of caveolin-1-regulated proteins: characterization of polymerase i and transcript release factor/CAVIN-1 IN endothelial cells. in Molecular & cellular proteomics : MCP 2010 (PubMed)

  4. Human Polyclonal PTRF Primary Antibody for IHC, IHC (p) - ABIN4348623 : Nighot, Leung, Ma: Chloride channel ClC- 2 enhances intestinal epithelial tight junction barrier function via regulation of caveolin-1 and caveolar trafficking of occludin. in Experimental cell research 2017 (PubMed)

  5. Human Monoclonal PTRF Primary Antibody for IHC (p), ELISA - ABIN567012 : Hansen, Bright, Howard, Nichols: SDPR induces membrane curvature and functions in the formation of caveolae. in Nature cell biology 2009 (PubMed)

  6. Human Polyclonal PTRF Primary Antibody for IP, WB - ABIN253106 : Sathish, Thompson, Sinha, Sieck, Prakash, Pabelick: Inflammation, caveolae and CD38-mediated calcium regulation in human airway smooth muscle. in Biochimica et biophysica acta 2013 (PubMed)

More Antibodies against PTRF Interaction Partners

Zebrafish Polymerase I and Transcript Release Factor (PTRF) interaction partners

Human Polymerase I and Transcript Release Factor (PTRF) interaction partners

  1. Data suggest that the predominant plasmalemmal anionic lipid phosphatidylserine is essential for proper caveolin/cavin clustering, caveola formation, and caveola dynamics; membrane scrambling (by using other phospholipids) can perturb caveolar stability; these studies involved caveolin-1 (show CAV1 Antibodies) and cavin-1 as models of caveolin/cavin clustering.

  2. DNA methylation (show HELLS Antibodies) profiling identifies PTRF/Cavin-1 as a novel tumor suppressor in Ewing sarcoma when co-expressed with caveolin-1 (show CAV1 Antibodies), which PTRF, disrupts the MDM2 (show MDM2 Antibodies)/p53 (show TP53 Antibodies) complex, leading to apoptosis.

  3. Results show that PTRF is a direct target of miR (show MLXIP Antibodies)-187. PTRF plays crucial roles in miR (show MLXIP Antibodies)-187-induced epithelial-mesenchymal transition and migration of non-small cell lung cancer cells.

  4. The expression of the PTRF protein was significantly weaker than that in the adjacent normal lung tissues using immunohistochemical staining. The findings revealed that miR187 promotes cell growth and invasion by targeting PTRF and miR187 may be a new prognostic factor for nonsmall cell lung cancer

  5. A homozygous PTRF mutation was identified in patient-1. Congenital generalized lipodystrophy type 4 was caused by homozygous PTRF c.481-482insGTGA (p.Lys161Serfs*41) mutation in patient-2.

  6. This study reports an unanticipated function of ROR1 (show ROR1 Antibodies) as a scaffold of cavin-1 and caveolin-1 (show CAV1 Antibodies), two essential structural components of caveolae.

  7. Cavin-1 and cavin-2 (show SDPR Antibodies) are strongly expressed within caveolae-like structures within liver sinusoidal endothelial cells of the hepatitis C-related cirrhotic liver and cavin-1 would play a critical role in regulating aspects of caveolin-1 (show CAV1 Antibodies).

  8. Rather than forming a single coat complex containing the three cavin family members, single-molecule analysis reveals an exquisite specificity of interactions between cavin1, cavin2 (show SDPR Antibodies) and cavin3 (show PRKCDBP Antibodies).

  9. Our data support a role for PTRF/cavin-1, through caveolae formation, as an attenuator of the non-caveolar functionality of Cav1 (show CAV1 Antibodies) in Gal3 (show LGALS3 Antibodies)-Cav1 (show CAV1 Antibodies) signalling and regulation of focal adhesion dynamics and cancer cell migration.

  10. this study presents a novel mutation of PTRF from Saudi Arabia and our findings broaden the mutation spectrum of PTRF in the familial CGL4 phenotype.

Mouse (Murine) Polymerase I and Transcript Release Factor (PTRF) interaction partners

  1. The current analyses reveal roles for cavin-1 and related proteins in governing myocardial contractile function and compliance, coronary and cardiac responses to mechanical and ischaemic stressors, and membrane permeability/fragility

  2. acetylated cavin-1 preferentially interacted with hormone-sensitive lipase (show LIPE Antibodies) and recruited it to the caveolae, thereby promoting lipolysis.

  3. these results suggested that the membrane dynamics in cell migration is affected by caveolae associated PTRF/cavin-1.

  4. study demonstrates a critical role of cavin-1 in vascular structure and function, but the influences on arterial resistance cancel each other such that arterial blood pressure remains unaltered in homeostatic conditions

  5. lipid mobilization in cultured adipocytes to induce lipid droplet shrinkage led to biphasic response of cavin-1 with ultimate loss of expression of cavin-1 by protein degradation.

  6. A Western-type diet in apo (show C9orf3 Antibodies)-E2 knock-in mice produced 3 groups of obese mice with PTRF expression correlating with glucose tolerance: normal, hyperinsulinemic glucose-tolerant, or impaired. PTRF compromised adipocyte differentiation of 3T3-L1 cells.

  7. Adipocytes from cavin-1-null mice are markedly dysfunctional exhibiting decreased insulin (show INS Antibodies)-dependent glucose uptake, fatty acid uptake, and lipolysis.

  8. PTRF is a crucial regulator of TLR4 (show TLR4 Antibodies) signaling in the development of sepsis.

  9. an important role for Cavin1 in lung homeostasis

  10. Cavin-1 is critical for detrusor caveolae and for overall contractility and structure of the urinary bladder.

PTRF Antigen Profile

Protein Summary

This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy.

Gene names and symbols associated with PTRF

  • polymerase I and transcript release factor (ptrf) antibody
  • polymerase I and transcript release factor (PTRF) antibody
  • polymerase I and transcript release factor b (ptrfb) antibody
  • polymerase I and transcript release factor (Ptrf) antibody
  • 2310075E07Rik antibody
  • AW546441 antibody
  • Cav-p60 antibody
  • Cavin antibody
  • cavin-1 antibody
  • CAVIN1 antibody
  • CGL4 antibody
  • fd20g07 antibody
  • MGC53017 antibody
  • MGC89141 antibody
  • ptrf antibody
  • wu:fd20g07 antibody
  • zgc:162917 antibody

Protein level used designations for PTRF

polymerase I and transcript release factor , leucine zipper protein , leucine-zipper protein , polymerase I and transcript release factor-like , RNA polymerase I and transcript release factor , TTF-I interacting peptide 12 , cavin-1 , cav-p60 , cavin

GENE ID SPECIES
380268 Xenopus laevis
396006 Gallus gallus
448589 Xenopus (Silurana) tropicalis
454684 Pan troglodytes
561082 Danio rerio
100411410 Callithrix jacchus
284119 Homo sapiens
490966 Canis lupus familiaris
538457 Bos taurus
19285 Mus musculus
287710 Rattus norvegicus
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