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PTRF encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. Additionally we are shipping PTRF Kits (10) and PTRF Proteins (6) and many more products for this protein.
Showing 10 out of 59 products:
Human Polyclonal PTRF Primary Antibody for ELISA, ICC - ABIN4240533
Hill, Bastiani, Luetterforst, Kirkham, Kirkham, Nixon, Walser, Abankwa, Oorschot, Martin, Hancock, Parton: PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function. in Cell 2008
Show all 2 Pubmed References
Human Polyclonal PTRF Primary Antibody for IP - ABIN253105
Dávalos, Fernández-Hernando, Sowa, Derakhshan, Lin, Lee, Zhao, Luo, Colangelo, Sessa: Quantitative proteomics of caveolin-1-regulated proteins: characterization of polymerase i and transcript release factor/CAVIN-1 IN endothelial cells. in Molecular & cellular proteomics : MCP 2010
Human Polyclonal PTRF Primary Antibody for IP, WB - ABIN253106
Sathish, Thompson, Sinha, Sieck, Prakash, Pabelick: Inflammation, caveolae and CD38-mediated calcium regulation in human airway smooth muscle. in Biochimica et biophysica acta 2013
Human Polyclonal PTRF Primary Antibody for IHC (p), WB - ABIN391621
Park, Yamaura, Kawamoto, Kurihara, Sato: Reciprocal modulation of surface expression of annexin A2 in a human umbilical vein endothelial cell-derived cell line by eicosapentaenoic acid and docosahexaenoic acid. in PLoS ONE 2014
Human Monoclonal PTRF Primary Antibody for IHC (p), ELISA - ABIN567012
Hansen, Bright, Howard, Nichols: SDPR induces membrane curvature and functions in the formation of caveolae. in Nature cell biology 2009
Human Polyclonal PTRF Primary Antibody for IHC, IHC (p) - ABIN4348623
Nighot, Leung, Ma: Chloride channel ClC- 2 enhances intestinal epithelial tight junction barrier function via regulation of caveolin-1 and caveolar trafficking of occludin. in Experimental cell research 2017
Data suggest that the predominant plasmalemmal anionic lipid phosphatidylserine is essential for proper caveolin/cavin clustering, caveola formation, and caveola dynamics; membrane scrambling (by using other phospholipids) can perturb caveolar stability; these studies involved caveolin-1 (show CAV1 Antibodies) and cavin-1 as models of caveolin/cavin clustering.
DNA methylation (show HELLS Antibodies) profiling identifies PTRF/Cavin-1 as a novel tumor suppressor in Ewing sarcoma when co-expressed with caveolin-1 (show CAV1 Antibodies), which PTRF, disrupts the MDM2 (show MDM2 Antibodies)/p53 (show TP53 Antibodies) complex, leading to apoptosis.
Results show that PTRF is a direct target of miR (show MLXIP Antibodies)-187. PTRF plays crucial roles in miR (show MLXIP Antibodies)-187-induced epithelial-mesenchymal transition and migration of non-small cell lung cancer cells.
The expression of the PTRF protein was significantly weaker than that in the adjacent normal lung tissues using immunohistochemical staining. The findings revealed that miR187 promotes cell growth and invasion by targeting PTRF and miR187 may be a new prognostic factor for nonsmall cell lung cancer
A homozygous PTRF mutation was identified in patient-1. Congenital generalized lipodystrophy type 4 was caused by homozygous PTRF c.481-482insGTGA (p.Lys161Serfs*41) mutation in patient-2.
This study reports an unanticipated function of ROR1 (show ROR1 Antibodies) as a scaffold of cavin-1 and caveolin-1 (show CAV1 Antibodies), two essential structural components of caveolae.
Cavin-1 and cavin-2 (show SDPR Antibodies) are strongly expressed within caveolae-like structures within liver sinusoidal endothelial cells of the hepatitis C-related cirrhotic liver and cavin-1 would play a critical role in regulating aspects of caveolin-1 (show CAV1 Antibodies).
Rather than forming a single coat complex containing the three cavin family members, single-molecule analysis reveals an exquisite specificity of interactions between cavin1, cavin2 (show SDPR Antibodies) and cavin3 (show PRKCDBP Antibodies).
Our data support a role for PTRF/cavin-1, through caveolae formation, as an attenuator of the non-caveolar functionality of Cav1 (show CAV1 Antibodies) in Gal3 (show LGALS3 Antibodies)-Cav1 (show CAV1 Antibodies) signalling and regulation of focal adhesion dynamics and cancer cell migration.
this study presents a novel mutation of PTRF from Saudi Arabia and our findings broaden the mutation spectrum of PTRF in the familial CGL4 phenotype.
The authors show here in mature adipocytes, ribosomal transcription can be acutely regulated in response to metabolic challenges. This acute response is mediated by PTRF (polymerase I transcription and release factor, also known as cavin-1), which has previously been shown to play a critical role in caveolae formation.
The current analyses reveal roles for cavin-1 and related proteins in governing myocardial contractile function and compliance, coronary and cardiac responses to mechanical and ischaemic stressors, and membrane permeability/fragility
acetylated cavin-1 preferentially interacted with hormone-sensitive lipase (show LIPE Antibodies) and recruited it to the caveolae, thereby promoting lipolysis.
these results suggested that the membrane dynamics in cell migration is affected by caveolae associated PTRF/cavin-1.
study demonstrates a critical role of cavin-1 in vascular structure and function, but the influences on arterial resistance cancel each other such that arterial blood pressure remains unaltered in homeostatic conditions
lipid mobilization in cultured adipocytes to induce lipid droplet shrinkage led to biphasic response of cavin-1 with ultimate loss of expression of cavin-1 by protein degradation.
A Western-type diet in apo (show C9orf3 Antibodies)-E2 knock-in mice produced 3 groups of obese mice with PTRF expression correlating with glucose tolerance: normal, hyperinsulinemic glucose-tolerant, or impaired. PTRF compromised adipocyte differentiation of 3T3-L1 cells.
Adipocytes from cavin-1-null mice are markedly dysfunctional exhibiting decreased insulin (show INS Antibodies)-dependent glucose uptake, fatty acid uptake, and lipolysis.
PTRF is a crucial regulator of TLR4 (show TLR4 Antibodies) signaling in the development of sepsis.
an important role for Cavin1 in lung homeostasis
This gene encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy.
polymerase I and transcript release factor
, leucine zipper protein
, leucine-zipper protein
, polymerase I and transcript release factor-like
, RNA polymerase I and transcript release factor
, TTF-I interacting peptide 12