Polyribonucleotide Nucleotidyltransferase 1 Proteins (PNPT1)

The protein encoded by PNPT1 belongs to the evolutionary conserved polynucleotide phosphorylase family comprised of phosphate dependent 3'-to-5' exoribonucleases implicated in RNA processing and degradation. Additionally we are shipping Polyribonucleotide Nucleotidyltransferase 1 Antibodies (101) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PNPT1 87178 Q8TCS8
PNPT1 71701 Q8K1R3
Rat PNPT1 PNPT1 360992  
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Top Polyribonucleotide Nucleotidyltransferase 1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$12,127.90
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
$12,127.90
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
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Escherichia coli (E. coli) Human His tag   20 μg Log in to see 2 to 3 Days
$458.77
Details

PNPT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Polyribonucleotide Nucleotidyltransferase 1 (PNPT1) Interaction Partners

Human Polyribonucleotide Nucleotidyltransferase 1 (PNPT1) interaction partners

  1. The PNPT1 p.Arg136His and p.Pro140Leu variants in our subject showed 1) the mutated amino acids are highly conserved and our structural analysis supported them to be functionally deleterious; 2) The carrier frequencies of the variants are very low in populations (1:60.000), with no homozygous carriers found; 3) The RC complex amounts in the subject's myoblasts were functionally rescued by expression of wild-type PNPT1.

  2. Inhibition of homologous PNPase by citrate may represent an evolutionarily conserved communicative link between RNA degradation and central metabolism.

  3. In vitro rescue experiments, using exogenous expression of wild-type PNPT1 in patient fibroblasts, ameliorated the deficiencies in the OXPHOS complex protein expression, supporting the likely pathogenicity of these variants and the importance of Whole-exome sequencingin efficiently identifying rare genetic disease genes

  4. this study provides further evidence that hPNPase(old-35) is associated with global changes in cell cycle-associated genes and identifies potential gene targets for future investigation

  5. fresh insight into cellular pathways regulated by PNPT1

  6. Interaction between PNPase and hSuv3 is essential for efficient mitochondrial RNA degradation.

  7. A mutation in PNPT1, encoding mitochondrial-RNA-import protein PNPase, causes hereditary hearing loss.

  8. Mutation in PNPT1, which encodes a polyribonucleotide nucleotidyltransferase, impairs RNA import into mitochondria and causes respiratory-chain deficiency.

  9. a novel role of nEGFR in radioresistance, and that is, upon ionizing radiation, nEGFR inactivates the ribonuclease activity of PNPase toward c-MYC (show MYC Proteins) mRNA through DNAPK (show PRKDC Proteins)-mediated Ser (show SIGLEC1 Proteins)-776 phosphorylation

  10. targeted overexpression of hPNPase(old-35) represents a novel strategy to selectively downregulate RNA expression and consequently intervene in a variety of pathophysiological conditions

Mouse (Murine) Polyribonucleotide Nucleotidyltransferase 1 (PNPT1) interaction partners

  1. The data support an unanticipated role for PNPASE in mediating the translocation of RNAs into mitochondria

Polyribonucleotide Nucleotidyltransferase 1 (PNPT1) Protein Profile

Protein Summary

The protein encoded by this gene belongs to the evolutionary conserved polynucleotide phosphorylase family comprised of phosphate dependent 3'-to-5' exoribonucleases implicated in RNA processing and degradation. This enzyme is predominantly localized in the mitochondrial intermembrane space and is involved in import of RNA to mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency-13 and autosomal recessive nonsyndromic deafness-70. Related pseudogenes are found on chromosomes 3 and 7.

Gene names and symbols associated with PNPT1

  • polyribonucleotide nucleotidyltransferase 1, mitochondrial (CpipJ_CPIJ005886)
  • polyribonucleotide nucleotidyltransferase 1 (PNPT1)
  • polyribonucleotide nucleotidyltransferase 1 (Pnpt1)
  • 1200003F12Rik protein
  • COXPD13 protein
  • DFNB70 protein
  • old-35 protein
  • Old35 protein
  • PNPase protein
  • Pnptl1 protein

Protein level used designations for PNPT1

polyribonucleotide nucleotidyltransferase 1, mitochondrial , 3'-5' RNA exonuclease OLD35 , PNPase 1 , PNPase old-35 , polynucleotide phosphorylase 1 , polynucleotide phosphorylase-like protein

GENE ID SPECIES
6037837 Culex quinquefasciatus
87178 Homo sapiens
481376 Canis lupus familiaris
508877 Bos taurus
71701 Mus musculus
360992 Rattus norvegicus
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