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Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. Additionally we are shipping Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 Kits (9) and Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 Proteins (6) and many more products for this protein.
Showing 10 out of 141 products:
Human Polyclonal KCNJ11 Primary Antibody for IF, IHC - ABIN1532705
Inagaki, Gonoi, Clement, Namba, Inazawa, Gonzalez, Aguilar-Bryan, Seino, Bryan: Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor. in Science (New York, N.Y.) 1996
Human Polyclonal KCNJ11 Primary Antibody for IHC (p), WB - ABIN374886
Filosa, Bonev, Straub, Meredith, Wilkerson, Aldrich, Nelson: Local potassium signaling couples neuronal activity to vasodilation in the brain. in Nature neuroscience 2006
A Conserved Residue Cluster That Governs Kinetics of ATP-dependent Gating of Kir6.2 Potassium Channels.
ATP-sensitive potassium currents from channels formed by Kir6 and a modified cardiac mitochondrial SUR2 (show ABCC9 Antibodies) variant
The Kir6.2-containing K-ATP channel is required for cardioprotection of resveratrol.
Report mechanical dyssynchrony as an early marker of cardiomyopathic disease in ATP-sensitive K channel (show KCNC4 Antibodies)-deficient dilated cardiomyopathy.
a role of K(ATP)-channel-dependent neuronal excitability in catecholaminergic neurons in maintaining thermogenic BAT (show BAAT Antibodies) sympathetic tone and energy homeostasis.
Data indicate that betaIV-Spectrin-targeted CaMKII (show CAMK2G Antibodies) directly phosphorylates the inwardly-rectifying potassium channel (show KCNAB2 Antibodies), Kir6.2.
Kir6.2 subunits are critical in resistance to endotoxemia-induced cardiac dysfunction through reducing myocardial damage by inhibition of apoptosis and inflammation.
These findings reveal unrecognized slide helix elements that are required for functional channel expression and control of Kir6.2 gating by intracellular ATP.
We found that perfused hearts from Kir6.2(-/-) mice exhibited a normal baseline response to ischemia-reperfusion injury, were not protected by ischemic preconditioning
Data from Kir6.2 knockout mice suggest that KATP channel-independent mechanism mediated by vagus nerve plays critical role in insulin (show INS Antibodies) secretion by pancreatic beta cells in response to eating of dietary carbohydrates.
This studypredict response ketogenic dietary therapies. showed that Common variants in KCNJ11 and BAD do not response to ketogenic diety therapy.
KCNJ11 genetic variants may have a role in the development of diabetes mellitus [review]
Mutations in KCNJ11 are associated with neonatal diabetes mellitus.
The hORs were coupled to the Kir6.2 potassium channel (show KCNAB2 Antibodies) for simple odorant detection.
We performed a retrospective cohort study using data on 58 individuals with neonatal diabetes due to KCNJ11 mutations
Polymorphism rs5219 of KCNJ11 gene is associated with type 2 diabetes.
KCNJ11 SNP was associated with diabetic retinopathy in Chinese Han patients with T2DM.
These calculations identified causal genetic variation within the ABCC8 (show ABCC8 Antibodies)/KCNJ11 region for type 2 diabetes mellitus.
A190A-TT or E23K-GG of the KCNJ11 in carriers had higher systolic blood pressure (SBP (show SHBG Antibodies)) than CC or AA carriers in the non-diabetic control and T2DM groups (both p < 0.05).
The KCNJ11 gene encodes for the Kir6.2 subunit of the ATP-sensitive potassium channel (show KCNAB2 Antibodies) in the pancreatic beta cell; thus, mutations in this gene cause impaired insulin (show INS Antibodies) secretion.
Although the expression level of Kir6.2 channel subtype does not differ between aortic smooth muscle cells of control and hypertrophied models, those of Kir6.1 (show KCNJ8 Antibodies) and SUR2B (show ABCC9 Antibodies) subtypes are reduced in left ventricular hypertrophy models.
islets express mRNA transcripts for sulfonylurea receptor 1 (Sur1 (show ABCC8 Antibodies)), inward rectifying potassium channel (show KCNAB2 Antibodies) (Kir6.2, associated with Sur1 (show ABCC8 Antibodies)), glucagon-like peptide 1 receptor (GLP1R (show GLP1R Antibodies)), and adrenergic receptor alpha 2A (show ADRA2A Antibodies) (ADRalpha2A)
The predominant K(ATP) channel expressed in pig urethral smooth muscle possesses a unique, heteromeric pore structure with a pore-forming subunit composition of (Kir6.1 (show KCNJ8 Antibodies))(3)-(Kir6.2).
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
potassium inwardly-rectifying channel, subfamily J, member 11
, potassium inwardly-rectifying channel J11
, ATP-sensitive inward rectifier potassium channel 11
, ATP-sensitive inward rectifier potassium channel 11-like
, inward rectifier K(+) channel Kir6.2
, potassium channel, inwardly rectifying subfamily J member 11
, potassium inwardly-rectifying channel subfamily J member 11
, inward rectifier potassium channel Kir6.2
, beta-cell inward rectifier subunit
, inwardly rectifying potassium channel KIR6.2
, potassium channel inwardly rectifing subfamily J member 11
, potassium inwardly rectifying channel, subfamily J, member 11
, ATP-sensitive inward rectifier potassium channel Kir6.2
, inwardly rectifying potassium channel Kir6.2