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anti-Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11) Antibodies

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. Additionally we are shipping Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 Kits (9) and Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KCNJ11 16514 Q61743
KCNJ11 83535 P70673
KCNJ11 3767 Q14654
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Top anti-Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 Antibodies at antibodies-online.com

Showing 10 out of 141 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB Western blot analysis of extracts from 3T3 cells, using Kir6.2 (Ab-224) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using Kir6.2 (Ab-224) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Goat Un-conjugated IHC, ELISA, WB ABIN238541 (0.1µg/ml) staining of Human Muscle lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Goat Un-conjugated IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Dog Goat Un-conjugated IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Rabbit Un-conjugated IF, ELISA, WB Western blot analysis of extracts from HeLa cells, using Kir6.2 (Phospho-Thr224) Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of HuvEc cells, using Kir6.2 (Phospho-Thr224) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated FACS, WB Western blot analysis of KCNJ11 Antibody (N-term) (ABIN653157) in mouse stomach tissue lysates (35 µg/lane). KCNJ11 (arrow) was detected using the purified polyclonal antibody. KCNJ11 Antibody (N-term) (ABIN653157) flow cytometry analysis of CEM cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IF, IHC (p), ELISA, WB Anti-KCNJ11 / Kir6.2 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN1102705 concentration 10 ug/ml. 50 μL Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated WB Mouse Kcnj11 Antibody (N-term)  western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the Mouse Kcnj11 antibody detected the Mouse Kcnj11 protein (arrow). Mouse Kcnj11 Antibody (N-term)  western blot analysis in mouse stomach tissue lysates (35ug/lane).This demonstrates the Mouse Kcnj11 antibody detected the Mouse Kcnj11 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Cow Rabbit Un-conjugated IC, IF, IHC, WB Immunofluorescent analysis of Kir6.2 staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a hidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of Kir6.2 staining in human brain cortex formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Log in to see 9 Days
$487.50
Details
Human Rabbit Un-conjugated EIA, FACS, WB Flow cytometry analysis of CEM cells using KCNJ11 Antibody (N-term) Cat.-No AP52309PU-N (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Western blot analysis of KCNJ11 Antibody (N-term) in mouse stomach tissue lysates (35ug/lane). KCNJ11 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details

KCNJ11 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 Antibodies

  1. Human Polyclonal KCNJ11 Primary Antibody for IF, IHC - ABIN1532705 : Inagaki, Gonoi, Clement, Namba, Inazawa, Gonzalez, Aguilar-Bryan, Seino, Bryan: Reconstitution of IKATP: an inward rectifier subunit plus the sulfonylurea receptor. in Science (New York, N.Y.) 1996 (PubMed)

  2. Human Polyclonal KCNJ11 Primary Antibody for IHC (p), WB - ABIN374886 : Filosa, Bonev, Straub, Meredith, Wilkerson, Aldrich, Nelson: Local potassium signaling couples neuronal activity to vasodilation in the brain. in Nature neuroscience 2006 (PubMed)

More Antibodies against Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 Interaction Partners

Mouse (Murine) Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11) interaction partners

  1. A Conserved Residue Cluster That Governs Kinetics of ATP-dependent Gating of Kir6.2 Potassium Channels.

  2. ATP-sensitive potassium currents from channels formed by Kir6 and a modified cardiac mitochondrial SUR2 (show ABCC9 Antibodies) variant

  3. The Kir6.2-containing K-ATP channel is required for cardioprotection of resveratrol.

  4. Report mechanical dyssynchrony as an early marker of cardiomyopathic disease in ATP-sensitive K channel (show KCNC4 Antibodies)-deficient dilated cardiomyopathy.

  5. a role of K(ATP)-channel-dependent neuronal excitability in catecholaminergic neurons in maintaining thermogenic BAT (show BAAT Antibodies) sympathetic tone and energy homeostasis.

  6. Data indicate that betaIV-Spectrin-targeted CaMKII (show CAMK2G Antibodies) directly phosphorylates the inwardly-rectifying potassium channel (show KCNAB2 Antibodies), Kir6.2.

  7. Kir6.2 subunits are critical in resistance to endotoxemia-induced cardiac dysfunction through reducing myocardial damage by inhibition of apoptosis and inflammation.

  8. These findings reveal unrecognized slide helix elements that are required for functional channel expression and control of Kir6.2 gating by intracellular ATP.

  9. We found that perfused hearts from Kir6.2(-/-) mice exhibited a normal baseline response to ischemia-reperfusion injury, were not protected by ischemic preconditioning

  10. Data from Kir6.2 knockout mice suggest that KATP channel-independent mechanism mediated by vagus nerve plays critical role in insulin (show INS Antibodies) secretion by pancreatic beta cells in response to eating of dietary carbohydrates.

Human Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11) interaction partners

  1. This studypredict response ketogenic dietary therapies. showed that Common variants in KCNJ11 and BAD do not response to ketogenic diety therapy.

  2. KCNJ11 genetic variants may have a role in the development of diabetes mellitus [review]

  3. Mutations in KCNJ11 are associated with neonatal diabetes mellitus.

  4. The hORs were coupled to the Kir6.2 potassium channel (show KCNAB2 Antibodies) for simple odorant detection.

  5. We performed a retrospective cohort study using data on 58 individuals with neonatal diabetes due to KCNJ11 mutations

  6. Polymorphism rs5219 of KCNJ11 gene is associated with type 2 diabetes.

  7. KCNJ11 SNP was associated with diabetic retinopathy in Chinese Han patients with T2DM.

  8. These calculations identified causal genetic variation within the ABCC8 (show ABCC8 Antibodies)/KCNJ11 region for type 2 diabetes mellitus.

  9. A190A-TT or E23K-GG of the KCNJ11 in carriers had higher systolic blood pressure (SBP (show SHBG Antibodies)) than CC or AA carriers in the non-diabetic control and T2DM groups (both p < 0.05).

  10. The KCNJ11 gene encodes for the Kir6.2 subunit of the ATP-sensitive potassium channel (show KCNAB2 Antibodies) in the pancreatic beta cell; thus, mutations in this gene cause impaired insulin (show INS Antibodies) secretion.

Rabbit Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11) interaction partners

  1. Although the expression level of Kir6.2 channel subtype does not differ between aortic smooth muscle cells of control and hypertrophied models, those of Kir6.1 (show KCNJ8 Antibodies) and SUR2B (show ABCC9 Antibodies) subtypes are reduced in left ventricular hypertrophy models.

Pig (Porcine) Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11) interaction partners

  1. islets express mRNA transcripts for sulfonylurea receptor 1 (Sur1 (show ABCC8 Antibodies)), inward rectifying potassium channel (show KCNAB2 Antibodies) (Kir6.2, associated with Sur1 (show ABCC8 Antibodies)), glucagon-like peptide 1 receptor (GLP1R (show GLP1R Antibodies)), and adrenergic receptor alpha 2A (show ADRA2A Antibodies) (ADRalpha2A)

  2. The predominant K(ATP) channel expressed in pig urethral smooth muscle possesses a unique, heteromeric pore structure with a pore-forming subunit composition of (Kir6.1 (show KCNJ8 Antibodies))(3)-(Kir6.2).

Potassium Inwardly-Rectifying Channel, Subfamily J, Member 11 (KCNJ11) Antigen Profile

Protein Summary

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Gene names and symbols associated with KCNJ11

  • potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11) antibody
  • potassium inwardly-rectifying channel, subfamily J, member 11 (kcnj11) antibody
  • potassium inwardly rectifying channel, subfamily J, member 11 (Kcnj11) antibody
  • BIR antibody
  • HHF2 antibody
  • IKATP antibody
  • KIR6.2 antibody
  • mBIR antibody
  • PHHI antibody
  • TNDM3 antibody

Protein level used designations for KCNJ11

potassium inwardly-rectifying channel, subfamily J, member 11 , potassium inwardly-rectifying channel J11 , ATP-sensitive inward rectifier potassium channel 11 , ATP-sensitive inward rectifier potassium channel 11-like , inward rectifier K(+) channel Kir6.2 , BIR , potassium channel, inwardly rectifying subfamily J member 11 , potassium inwardly-rectifying channel subfamily J member 11 , IKATP , inward rectifier potassium channel Kir6.2 , beta-cell inward rectifier subunit , inwardly rectifying potassium channel KIR6.2 , potassium channel inwardly rectifing subfamily J member 11 , potassium inwardly rectifying channel, subfamily J, member 11 , ATP-sensitive inward rectifier potassium channel Kir6.2 , inwardly rectifying potassium channel Kir6.2

GENE ID SPECIES
428846 Gallus gallus
466450 Pan troglodytes
664687 Danio rerio
100401039 Callithrix jacchus
100456411 Pongo abelii
16514 Mus musculus
83535 Rattus norvegicus
100135564 Cavia porcellus
3767 Homo sapiens
485401 Canis lupus familiaris
100008648 Oryctolagus cuniculus
100158240 Sus scrofa
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