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The protein encoded by PTCRA is a single-pass type I membrane protein that is found in immmature but not mature T-cells. Additionally we are shipping PTCRA Antibodies (22) and many more products for this protein.
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pre-TCR expression is not essential for thymic differentiation to DP cells or for V-DJbeta suppression
Combined expression of pTalpha and Notch3 (show NOTCH3 Proteins) in T cell leukemia identifies the requirement of preTCR for leukemogenesis
The cytoplasmic tail of pTalpha plays a critical role in T lymphocyte development.
pTalpha plays a role in protecting developing thymocytes from DNA damage in mice
the dosage of E2A (show TCF3 Proteins), HEB, and SCL (show TAL1 Proteins) determines pT alpha gene expression in immature T cells
when in competition with pTalpha, TCRalpha induced defective proliferation, survival, and differentiation of alphabeta T lymphocyte precursors
High levels of pre-T cell receptor alpha-chain mRNA splice forms have been demonstrated in immature CD2 (show CD2 Proteins)+CD7 (show CDK7 Proteins)+CD3 (show CD3 Proteins)- T cells of the jejunal mucosa, both intraepithelially and in lamina propria.
identified a polyproline-arginine sequence in the pTalpha cytoplasmic tail that interacted in vitro with SH3 domains of the CIN85 (show SH3KBP1 Proteins)/CMS (show Cd2ap Proteins) family of adaptors, and mediated the recruitment of multiprotein complexes involving all (CMS (show Cd2ap Proteins), CIN85 (show SH3KBP1 Proteins), and CD2BP3 (show SH3KBP1 Proteins)) members
The protein encoded by this gene is a single-pass type I membrane protein that is found in immmature but not mature T-cells. Along with TCRB and CD3 complex, the encoded protein forms the pre-T-cell receptor complex, which regulates early T-cell development. Four transcript variants encoding different isoforms have been found for this gene.
pre T-cell antigen receptor alpha
, pre-T-cell receptor alpha chain