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The protein encoded by PDYN is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. Additionally we are shipping PDYN Kits (20) and PDYN Proteins (3) and many more products for this protein.
Showing 10 out of 112 products:
Mouse (Murine) Polyclonal PDYN Primary Antibody for WB - ABIN611204
Agarwal, Baek, Jeon, Miyamoto, Ueno, Yoon: Stimulation of transcript elongation requires both the zinc finger and RNA polymerase II binding domains of human TFIIS. in Biochemistry 1991
Show all 4 references for ABIN611204
Human Polyclonal PDYN Primary Antibody for IHC (fro), IHC (p) - ABIN121536
Beck, Goussakov, Lie, Helmstaedter, Elger: Synaptic plasticity in the human dentate gyrus. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2000
Show all 3 references for ABIN121536
Guinea Pig Polyclonal PDYN Primary Antibody for IHC (fro), RIA - ABIN121537
Neal, Newman et al.: Prodynorphin peptide distribution in the forebrain of the Syrian hamster and rat: a comparative study with antisera against dynorphin A, dynorphin B, and the C-terminus of the prodynorphin precursor ... in The Journal of comparative neurology 1989
Show all 2 references for ABIN121537
Mammalian Monoclonal PDYN Primary Antibody for IHC - ABIN283766
Commons: Neuronal pathways linking substance P to drug addiction and stress. in Brain research 2010
The Xen-dorphin prohormone is a new opioid-like prohormone distinct from proenkephalin (show PENK Antibodies) and prodynorphin.
Influence of age and 17beta-estradiol on kisspeptin, neurokinin B, and prodynorphin gene expression in the arcuate-median eminence.
This study found a significant haplotype-by-sex interaction, suggesting association with alcohol dependence in males but not females. The findings suggest that sex-dependent effects of PDYN variants in alcohol dependence are phenotype-specific.
PDYN gene promoter polymorphism might contribute to familial-risk temporal lobe epilepsy. (Review, meta-analysis)
The results demonstrate that DYN 1-17 and certain N-terminal fragments, produced in an inflamed environment, play an anti-inflammatory role by inhibiting NF-kappaB (show NFKB1 Antibodies)/p65 (show GORASP1 Antibodies) translocation.
Enhanced event-related potentials amplitudes suggest a hyper-active performance monitoring system in high PDYN expression individuals, and this might also be an indicator of a higher risk for internalizing disorders
This study generated the first mouse model for SCA23 and shown that mice expressing PDYN-R212W recapitulate many characteristics of the human phenotype of SCA23
Studied differential DNA-protein interactions of PDYN and OPRK1 (show OPRK1 Antibodies) SNPs significantly associated with alcohol dependence.
REST represses PDYN expression in SH-SY5Y cells and the adult human brain and may have implications for mental health and brain/mental disorders.
This study demonistratedn that Neurocognitive and neuroinflammatory correlates of PDYN mRNA expression in the anterior cingulate in postmortem brain of HIV-infected subjects.
Data indicate that the minor allele of PDYN rs2281285 was associated with an increased risk of drinking to avoid/escape unwanted emotional or somatic events.
To investigate the frequency of SCA23 among the Chinese Han population, we performed polymerase chain reaction (PCR) and DNA direct sequencing of the PDYN gene in 305 unrelated ataxia (show USP14 Antibodies) patients
The expression of the genes coding for proopiomelanocortin (POMC (show POMC Antibodies)), proenkephalin (PENK (show PENK Antibodies)) and prodynorphin (PDYN) in porcine luteal cells isolated from corpora lutea (CL) collected on days 3-6, 8-10 and 13-16 of the oestrous cycle is reported.
We found potential links between the alterations in expression of Tsc22d3 (show TSC22D3 Antibodies), Nfkbia (show NFKBIA Antibodies) and Pdyn, and different aspects of susceptibility to stress.
This study identify that photostimulation of dyn-expressing cells in discrete subregions within the NAcSh drive opposing motivational behavioral states
The results of this study indicated that PDYN have a differential role in cue-induced reinstatement of cocaine-seeking behavior.
Double NPY (show NPY Antibodies) and dynorphin deletion resulted in heavier mice, with increased adiposity, despite no significant changes in food intake or UCP-1 (show UCP1 Antibodies) activity.
These findings identify a unique cellular process by which orexin (show OX Antibodies) can occlude the reward threshold-elevating effects of coreleased dynorphin and thereby act in a permissive fashion to facilitate reward.
Data suggest that activation of neurokinin 3 and kappa-opioid receptors (NK3R (show TACR3 Antibodies) and KOR (show OPRK1 Antibodies)) excites and inhibits kisspeptin, neurokinin B (NKB), and dynorphin (KNDy neurons).
The results of this study suggested that elevated Pdyn expression during normal aging reduces mGluR (show GRM8 Antibodies) expression and signaling, which in turn impairs cognitive functions and increases anxiety.
Thus the dynorphin system, acting via neuropeptide y (show NPY Antibodies), may represent a pathway by which higher processes including stress, reward/addiction and depression influence skeletal metabolism
sex and genetic background have an effect on anxiety-related and stress-induced behaviour of prodynorphin-deficient mice
A role of dynorphin and kappa opioid receptor (show OPRK1 Antibodies) signaling are established in fear extinction that resulted in impaired extinction of context-specific fear response.
The investigation of Dyn (show SPTBN4 Antibodies) A 1-17 metabolism at the blood-brain barrier (BBB (show ALMS1 Antibodies)) is important since the metabolites exhibit unique biological functions compared to the parent compound.
The protein encoded by this gene is a preproprotein that is proteolytically processed to form the secreted opioid peptides beta-neoendorphin, dynorphin, leu-enkephalin, rimorphin, and leumorphin. These peptides are ligands for the kappa-type of opioid receptor. Dynorphin is involved in modulating responses to several psychoactive substances, including cocaine. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
, dorphin A
, dorphin B
, proenkephalin-B preproprotein
, neoendorphin-dynorphin-enkephalin prepropeptide
, preproenkephalin B
, proenkephalin B