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Programmed Cell Death 10 Proteins (PDCD10)

PDCD10 encodes an evolutionarily conserved protein associated with cell apoptosis. Additionally we are shipping PDCD10 Antibodies (55) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PDCD10 11235 Q9BUL8
PDCD10 56426 Q8VE70
Rat PDCD10 PDCD10 494345 Q6NX65
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Top PDCD10 Proteins at antibodies-online.com

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Xenopus laevis His tag   1 mg Log in to see 56 to 66 Days
$2,522.67
Details
HOST_Escherichia coli (E. coli) Human His tag   20 μg Log in to see 15 to 19 Days
$281.82
Details
HOST_Escherichia coli (E. coli) Human His tag   20 μg Log in to see 5 Days
$167.48
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PDCD10 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Programmed Cell Death 10 (PDCD10) Interaction Partners

Human Programmed Cell Death 10 (PDCD10) interaction partners

  1. Studies suggest that the 3 proteins of the Cerebral Cavernous Malformations (CCM) complex KRIT1/CCM1 (show KRIT1 Proteins), CCM2/malcavernin (show CCM2 Proteins) and CCM3/PDCD10 not only require one another for reciprocal stabilization, but also act as a platform for signal transduction.

  2. Study highlights the potential role of CCM3 in regulating tight junction complex organization and brain endothelial barrier permeability through CCM3-ERK1/2-cortactin (show CTTN Proteins) cross-talk

  3. A novel CCM3 missense mutation (c.422T>G) detected in 2 Greek brothers with cerebral cavernous malformations causes a loss of function in Pdcd10 protein due to its localization in the 8th helix. It affects Leu141. It may play a role in angiogenesis.

  4. The proto-oncogene (show RAB1A Proteins) PDCD10 is direct target of miR (show MLXIP Proteins)-103 that can suppress Prostate cancer proliferation and migration by down-regulating the PDCD10.

  5. We report for the first time that PDCD10 expression is downregulated in GBM, which is associated with the activation of Akt (show AKT1 Proteins) signaling protein

  6. miR (show MLXIP Proteins)-181b was upregulated by hypoxia in retinoblastoma in an HIF-1a (show HIF1A Proteins)-independent manner. Additionally, miR (show MLXIP Proteins)-181b exerts its angiogenic function, at least in part, by inhibiting PDCD10 and GATA6 (show GATA6 Proteins).

  7. Results broaden our knowledge on the mechanisms by which CCM3 deficiency results in disease and open new avenues of research into both CCM3 and senescence biology.

  8. Study shows that PDCD10 mutations result in vascular permeability mediated by ROCK activity and a particularly severe clinical phenotype of patients and mouse model for cerebral cavernous malformation disease.

  9. A causative mutation in the PDCD10 gene (p.Gln112PhefsX13) was identified in an Italian family with cerebral cavernous malformations associated with meningioma.

  10. Our results suggest that MST4 (show MST4 Proteins), STK25 (show STK25 Proteins) and PDCD10 are upregulated in prostate cancer and may play roles in prostate tumorigenesis.

Mouse (Murine) Programmed Cell Death 10 (PDCD10) interaction partners

  1. CCM3 expression and it's role during ovary and testis development

  2. Study shows that PDCD10 mutations result in vascular permeability mediated by ROCK activity and a particularly severe clinical phenotype of patients and mouse model for cerebral cavernous malformation disease.

  3. Data show that sulindac sulfide (show SQRDL Proteins) and sulindac sulfone, which attenuate beta-catenin (show CTNNB1 Proteins) transcription activity, reduce vascular malformations in endothelial programmed cell death 10 protein CCM3-deficient mice.

  4. CCM3 has both cell autonomous and cell non-autonomous functions in neural progenitors and is specifically required in radial glia and newly born pyramidal neurons migrating through the subventricular zone

  5. Although CCM3 stabilizes STK24, it counteracts STK24-mediated inhibition of exocytosis by recruiting STK24 away from the C2B domain through its Ca(2+)-sensitive interaction with UNC13D C2A domain.

  6. Pdcd10 has a different role in cerebral cavernous malformation than Ccm2 (show CCM2 Proteins) and Krit1 (show KRIT1 Proteins)

  7. Ccm3 has both neural cell autonomous and nonautonomous functions.

  8. Stabilization of VEGFR2 (show KDR Proteins) signaling by cerebral cavernous malformation 3 (also known as PDCD10) is critical for vascular development.

PDCD10 Protein Profile

Protein Summary

This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Gene names and symbols associated with PDCD10

  • programmed cell death 10 (LOC100232628)
  • programmed cell death 10 (PDCD10)
  • programmed cell death 10 (Pdcd10)
  • programmed cell death 10 (pdcd10)
  • 2410003B13Rik protein
  • Ccm3 protein
  • Tfa15 protein
  • Tfar15 protein

Protein level used designations for PDCD10

programmed cell death 10 , TF-1 cell apoptosis-related protein 15 , apoptosis-related protein 15 , cerebral cavernous malformations 3 protein , programmed cell death protein 10

GENE ID SPECIES
100232628 Taeniopygia guttata
11235 Homo sapiens
56426 Mus musculus
494345 Rattus norvegicus
425003 Gallus gallus
100157978 Sus scrofa
379916 Xenopus laevis
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