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Proopiomelanocortin Proteins (POMC)

POMC encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. Additionally we are shipping POMC Antibodies (232) and POMC Kits (77) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
POMC 18976 P01193
POMC 5443 P01189
POMC 24664  
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Top POMC Proteins at

Showing 10 out of 23 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
HOST_Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Rat His tag,GST tag 100 μg Log in to see 11 to 13 Days
HOST_Escherichia coli (E. coli) Human His tag,HIS-T7 100 μg Log in to see 11 to 13 Days
Yeast Oncorhynchus keta His tag   1 mg Log in to see 56 to 66 Days
Yeast Sheep His tag   1 mg Log in to see 56 to 66 Days
Yeast Guinea Pig His tag   1 mg Log in to see 56 to 66 Days
Yeast Macaca nemestrina His tag   1 mg Log in to see 56 to 66 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days

POMC Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,
Human , ,
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Rat (Rattus) , ,
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Top referenced POMC Proteins

  1. Human POMC Protein expressed in Escherichia coli (E. coli) - ABIN667920 : Belgardt, Okamura, Brüning: Hormone and glucose signalling in POMC and AgRP neurons. in The Journal of physiology 2009 (PubMed)
    Show all 2 references for ABIN667920

  2. Human POMC Protein expressed in Wheat germ - ABIN1315730 : La Rosa, Uccella, Dainese, Marchet, Placidi, Vigetti, Capella: Characterization of c-kit (CD117) expression in human normal pituitary cells and pituitary adenomas. in Endocrine pathology 2008 (PubMed)

More Proteins for Proopiomelanocortin (POMC) Interaction Partners

Zebrafish Proopiomelanocortin (POMC) interaction partners

  1. We identify the neuronal regulatory region of zebrafish pomca and confirm that it is not homologous to the mammalian enhancers.

  2. Hypothalamic pro-opiomelanocortin and AgRP (show AGRP Proteins) neurons are hypophysiotropic, projecting to the pituitary to coordinately regulate multiple pituitary hormones.

  3. cloning and characterization of the pro-opiomelanocortin gene

  4. Zebrafish proopiomelanocortin (zfPOMC) contains the consensus sequences for ACTH, gamma-LPH, beta-MSH and beta-endorphin (beta-END). RT-PCR expression studies indicate that zfPOMC is selectively expressed in nervous tissue and in the pituitary gland.

  5. Pituitary expression of proopiomelanocortin provides a unique marker for pituitary anterior and intermediate lobe morphogenesis.

Mouse (Murine) Proopiomelanocortin (POMC) interaction partners

  1. Epo (show EPO Proteins) regulates hypothalamus POMC expression via STAT3 (show STAT3 Proteins) activation.

  2. Data suggest that the solitary tract pro-opiomelanocortin (NTSPOMC) neurons were involved in cardiorespiratory control and endogenous analgesia.

  3. hypothalamic arcuate nucleus (Arc (show NOL3 Proteins))POMC-deficient mice, which develop severe obesity and insulin (show INS Proteins) resistance, unexpectedly exhibit improved glucose tolerance and remain protected from hyperglycemia via decreased renal GLUT2 (show SLC2A2 Proteins) expression and glycosuria.

  4. Hypomethylation of POMC promoter occurred in the hypothalamus of the high sucrose diet offspring compared with controls.

  5. Together, these results suggest that alpha-MSH alleviates Dex-induced damages to cultured osteoblasts through activating MC4R (show MC4R Proteins)-SphK1 (show SPHK1 Proteins) signaling.

  6. These data indicate that glucose induces distinct excitatory synaptic plasticity in different subpopulations of POMC neurons.

  7. Although genetic deletion of either Atg12 (show ATG12 Proteins) or Atg5 (show ATG5 Proteins) renders POMC neurons autophagy-deficient, mice lacking Atg5 (show ATG5 Proteins) in POMC neurons do not exhibit these phenotypes.

  8. Data indicate that LIM-homeodomain (show LHX2 Proteins) transcription factor Islet 1 (show ISL1 Proteins) is necessary for hypothalamic proopiomelanocortin gene (Pomc) expression during embryogenesis.

  9. these results reveal that cooperative interactions between the enhancers confer robustness of Pomc expression against gene regulatory disturbances and preclude deleterious metabolic phenotypes caused by Pomc deficiency in adulthood

  10. In contrast to mice with total hypothalamic Pomc deficiency, which are severely obese, mice with Lepr (show LEPR Proteins)-restricted Pomc expression displayed fully normal body weight, food consumption, glucose homeostasis, and locomotor activity.

Human Proopiomelanocortin (POMC) interaction partners

  1. The aim of this survey is to evaluate the association of genetic variants of melanocortin-4-receptor (MC4R (show MC4R Proteins)), pro-opiomelanocortin (POMC), apolipoprotein E (APOE (show APOE Proteins)) and agouti-related protein (AGRP (show AGRP Proteins)) with obesity in the North Indian population.

  2. The expression of Pomc mRNA was stimulated in the arcuate nucleus after skin exposure to UVB.

  3. hsa (show CD24 Proteins)-miR (show MLXIP Proteins)-34a can regulate the CRH (show CRH Proteins)/CRHR1 (show CRHR1 Proteins)/POMC axis and may influence body mass index.

  4. these common variants in PCSK1 (show PCSK1 Proteins) and POMC were not the major cause of obesity in the Thai subjects sampled. However, variants in PCSK1 (show PCSK1 Proteins) did affect cholesterol level, LDL-C level, and waist circumference.

  5. ACTH was readily detected at significantly higher levels in regions of ACTH-secreting adenomas and in normal anterior adenohypophysis compared with non-secreting adenoma and neurohypophysis.

  6. CSF (show CSF2 Proteins) POMC was higher in lean vs. overweight/obese subjects.

  7. There was a non-linear association between leukocyte telomere length and plasma ACTH after laboratory stressor in elderly adults.

  8. Synovial fluid alpha-MSH levels showed an independent and negative correlation with articular cartilage degeneration in patients with knee ACL (show ACLY Proteins) deficiency.

  9. This study suggest the involvement of genetic variants of POMC in the outcome of antidepressant treatment in patients with MDD, and indicate the possibility of an interaction of this association with stressful life events.

  10. Term infants born with meconium-stained amniotic fluid (MSAF) and who experienced respiratory distress had significantly lower levels of ACTH and cortisol at birth compared with well term infants born with MSAF or clear amniotic fluid.

Pig (Porcine) Proopiomelanocortin (POMC) interaction partners

  1. The expression of the genes coding for proopiomelanocortin (POMC), proenkephalin (PENK (show PENK Proteins)) and prodynorphin (PDYN (show PDYN Proteins)) in porcine luteal cells isolated from corpora lutea (CL) collected on days 3-6, 8-10 and 13-16 of the oestrous cycle is reported.

Cow (Bovine) Proopiomelanocortin (POMC) interaction partners

  1. The association has been reported between polymorphisms of the CRH (show CRH Proteins) and POMC genes with economic traits in Korean cattle.

  2. Expression of the hepatic endocannabinoid system and proopiomelanocortin was altered by plane of dietary energy prepartum particularly during the first 2-week postpartum.

  3. Significant associations were observed between POMC c.288C>T with start-of-finishing weight (SOF (show GJA1 Proteins) WT; P = 0.04), hot carcass weight (HCW; P = 0.02), average fat and grade fat (both P = 0.05), carcass rib-eye area (REA (show PHB2 Proteins); P = 0.03) and marbling

  4. The polymorphism of POMC gene is associated with the growth traits of Nanyang cattle.

POMC Protein Profile

Protein Summary

This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used\; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.

Gene names and symbols associated with Proopiomelanocortin Proteins (POMC)

  • proopiomelanocortin a (pomca)
  • pro-opiomelanocortin-alpha (Pomc)
  • proopiomelanocortin (POMC)
  • proopiomelanocortin (Pomc)
  • proopiomelanocortin preproprotein-like (LOC100344462)
  • ACTH protein
  • alpha-MSH protein
  • alphaMSH protein
  • BE protein
  • Beta-LPH protein
  • beta-MSH protein
  • CLIP protein
  • Gamma-LPH protein
  • gamma-MSH protein
  • LPH protein
  • MSH protein
  • NPP protein
  • POC protein
  • pomc protein
  • Pomc-1 protein
  • Pomc1 protein
  • Pomc2 protein
  • SI:bZ36D5.1 protein
  • si:bz36d5.2 protein
  • SI:bZ36D5.4 protein

Protein level used designations for Proopiomelanocortin Proteins (POMC)

beta-endorphin , pro-opiomelanocortin , adrenal corticotropic hormone , adrenocorticotropic hormone , alpha-melanocyte stimulating hormone , corticotropin-like intermediary peptide , corticotropin-lipotropin , melanotropin gamma , met-enkephalin , adrenocorticotropin , alpha-MSH , alpha-melanocyte-stimulating hormone , beta-LPH , beta-MSH , beta-melanocyte-stimulating hormone , gamma-LPH , gamma-MSH , lipotropin beta , lipotropin gamma , melanotropin alpha , melanotropin beta , opiomelanocortin prepropeptide , pro-ACTH-endorphin , proopiomelanocortin preproprotein , pro-opiomelanocortin-alpha , proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin) , proopiomelanocortin, beta (endorphin, beta) , proopoimelanocortin, beta (endorphin, beta) , Corticotropin-lipotropin , beta-lipotropin , beta-melanocyte stimulating hormone , pro-opiomelanocortin a-1 , pro-opiomelanocortin a-2 , pro-opiomelanocortin b-1 , pro-opiomelanocortin b-2

353221 Danio rerio
18976 Mus musculus
5443 Homo sapiens
24664 Rattus norvegicus
443212 Ovis aries
100720803 Cavia porcellus
396863 Sus scrofa
281416 Bos taurus
100861398 Capra hircus
403659 Canis lupus familiaris
422011 Gallus gallus
100344462 Oryctolagus cuniculus
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