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may regulate renin release and renal ion transport. Additionally we are shipping and Protein Kinase, CGMP-Dependent, Type II Kits (6) and many more products for this protein.
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Human Polyclonal PRKG2 Primary Antibody for IHC (p), WB - ABIN392537
Vaandrager, Hogema, Edixhoven, van den Burg, Bot, Klatt, Ruth, Hofmann, Van Damme, Vandekerckhove, de Jonge: Autophosphorylation of cGMP-dependent protein kinase type II. in The Journal of biological chemistry 2003
Show all 7 Pubmed References
This study indicates that loss of PRKG2 function results in differential expression of P53 (show TP53 Antibodies) regulated genes as well as additional pathways consistent with increased proliferation and apoptosis in the growth plate due to achondroplastic dwarfism.
PRKG2 R678X as a causative mutation for dwarfism cattle was presented.
These affinity and activation measurements show that beta-phenyl-1,N2-ethenoguanosine 3',5'-monophosphate (PET-cGMP) is most selective for PKG (show PRKG1 Antibodies) I, whereas 8-(4-chlorophenylthio)guanosine-3'-5'-cyclic monophosphate (8-pCPT-cGMP) is most selective for PKG (show PRKG1 Antibodies) II.
PKG (show PRKG1 Antibodies) II inhibits EGFinduced activation of HER2 (show ERBB2 Antibodies) through binding with and causing threonine 686 phosphorylation of this oncogenic protein.
The C-terminal cyclic nucleotide binding (CNB (show PPP3R1 Antibodies)-B) domain of cGMP-dependent protein kinase II binds cGMP with higher affinity and selectivity when compared with its N-terminal CNB (CNB (show PPP3R1 Antibodies)-A) domain.
Han Chinese patients with rs10033237 polymorphism of cGKII/PRKG2 gene are more likely to suffer from gout.
Our replication study suggests that cGKII is not involved in gout susceptibility.
we determined a crystal structure of the PKG (show PRKG1 Antibodies) II LZ-Rab11b (show RAB11B Antibodies) complex. The PKG (show PRKG1 Antibodies) II LZ domain presents a mostly nonpolar surface onto which Rab11b (show RAB11B Antibodies) docks, through van (show TNIP1 Antibodies) der (show GDF3 Antibodies) Waals interactions
PKGII inhibits RhoA (show RHOA Antibodies) activity by binding to this small GTPase (show RACGAP1 Antibodies) and causing phosphorylation at its Ser188 site.
PKG (show PRKG1 Antibodies) II also inhibits the activation of the EGFR (show EGFR Antibodies) caused by diverse ligands of the receptor.
These data suggest that increased PKG (show PRKG1 Antibodies) II activity attenuates bFGFinduced proliferation and migration by inhibiting the MAPK/ERK (show MAPK1 Antibodies) signaling pathway, whereas PKG (show PRKG1 Antibodies) I does not
type II cGMPdependent protein kinase (show CDK7 Antibodies) prevented the EGF (show EGF Antibodies)-induced phosphorylation/activation of ERK (show EPHB2 Antibodies) and JNK (show MAPK8 Antibodies), but not the phosphorylation of p38MAPK (show MAPK14 Antibodies) induced by EGF (show EGF Antibodies).
cGKII may play a role in the integration of information that conveys both anxiety-provoking stimuli as well as the spatial and environmental cues that facilitate functional memory processes and appropriate behavioral response.
urine volume was decreased significantly in cGKII-KO subjected to volume load.
Cyclic GMP kinase (show GUK1 Antibodies) II (cGKII) inhibits NHE3 (show SLC9A3 Antibodies) by altering its trafficking and phosphorylating NHE3 (show SLC9A3 Antibodies) at three required sites
Increased PKG2 activity alters homeostasis by suppressing proliferation and apoptosis while promoting differentiation. The PKG2-dependent mechanism was shown to involve increased DUSP10 (show DUSP10 Antibodies) and subsequent inhibition of JNK (show MAPK8 Antibodies) activity.
cGKII KO mice are significantly deficient in spatial learning while exhibiting facilitated motor coordination. Data suggest that the role of cGKII may be more robust in particular regions.
cGKII and HCN2 (show HCN2 Antibodies) interact and colocalize with each other
The homeobox (show PRRX1 Antibodies) gene Nkx family is critical for the transcriptional regulation of cGK-II during chondrogenesis.
Inhibition of cGMP-dependent protein kinase II by its own splice isoform
study provides in vivo and in vitro genetic evidence that cGKII plays a critical role in C-type natriuretic peptide (show NPPC Antibodies)-mediated endochondral ossification
results show that the fast phase of autophosphorylation of cGMP dependent protein kinase II has a small effect on its activity, whereas the secondary phase involving Ser126 phosphorylation may generate an active form
may regulate renin release and renal ion transport
protein kinase, cGMP-dependent, type II
, cGMP-dependant type II protein kinase
, cGMP-dependent protein kinase 2
, cGMP-dependent protein kinase 2-like
, cGK 2
, cGMP-dependent protein kinase II
, CGK 2
, cGMP dependent protein kinase type II
, protein kinase cGMP- dependent type 2
, protein kinase, cGMP- dependent, type 2
, protein kinase, cGMP- dependent, type II
, type II cGMP-dependent protein kinase