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The protein encoded by PKD2 belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. Additionally we are shipping PKD2 Kits (11) and PKD2 Proteins (10) and many more products for this protein.
Showing 10 out of 124 products:
Human Polyclonal PKD2 Primary Antibody for IP, WB - ABIN152061
Liu, Evans, Britton, Zachary: The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis. in Oncogene 2008
Show all 8 references for ABIN152061
Human Polyclonal PKD2 Primary Antibody for EIA, IHC (p) - ABIN360330
Stayner, Zhou: Polycystin channels and kidney disease. in Trends in pharmacological sciences 2001
Show all 5 references for ABIN360330
Novel PKD2 mutations in Chinese autosomal dominant polycystic kidney disease patients
Two neutral missense PKD2 variants indentified in exon1 c.83G>C (p.R28P) and c.568G>A (p.A190T), which the former segregate with the mutation in affected relatives, and two new intronic and 3'UTR (show UTS2R Antibodies) variants, c.1548+63C>T and c.*363delA.
this study presents the cryo-EM structure of PKD2 in lipid bilayers at 3.0 A resolution, which establishes PKD2 as a homotetrameric ion channel and provides insight into potential mechanisms for its activation.
PCs expression and p53 (show TP53 Antibodies) activation as a regulator of cell proliferation were further evaluated in vivo and in 69 advanced human carotid atherosclerotic plaques.
PKD2 and RSK1 (show RPS6KA1 Antibodies) regulate integrin beta4 phosphorylation at threonine 1736 to stabilize keratinocyte cell adhesion and its hemidesmosomes.
The coiled-coil domain in the PC2 (show KRT6B Antibodies) C-terminal forms a stable helix bundle regardless of the presence of Ca(2 (show CA2 Antibodies)+).
Results show that some of the previously reported missense or synonymous mutations in PKD2 gene caused altered pre-mRNA splicing.
PKD2 is a core factor in the formation of this multiprotein complex at the TGN (show TG Antibodies) that controls constitutive secretion of matrix metalloproteinase (show MMP20 Antibodies) cargo.
Human polycystin-2 transgene dose-dependently rescues autosomal-dominant polycystic kidney disease phenotypes in Pkd2 mutant mice
FLNA (show FLNA Antibodies) anchors PC2 (show KRT6B Antibodies) to the actin cytoskeleton through complex PC2 (show KRT6B Antibodies)-FLNA (show FLNA Antibodies)-actin to reduce degradation and increase stability, and possibly regulate PC2 (show KRT6B Antibodies) function in a Ca-dependent manner.
Our studies demonstrate that PKD1 (show PKD1 Antibodies)/2 is a key regulator of MVB maturation and exosome secretion, and constitutes a mediator of the DGK alpha (show DGKA Antibodies) effect on MVB secretory traffic.
Results reveal that whereas protein kinase D1 (show PRKD1 Antibodies) and protein kinase D2 are essential for neuronal polarity, there exists a functional redundancy between the two proteins.
PKD2 acted as an amplification checkpoint for antigen-stimulated digital cytokine responses and translated the differential strength of TCR signaling to determine the number of naive CD8 (show CD8A Antibodies)(+) T cells that became effector cells.
Protein kinase D2 promotes in vitro osteoclast differentiation and fusion
A bioinformatic screen identified the serine-threonine kinase (show CDK4 Antibodies) protein kinase D2 (PRKD2) as a potential effector of GABP in hematopoietic stem cells
Transcriptional profiling reveals the full consequences of PKD2 loss and maps in detail the selective, but critical, function for PKD2 in signalling by alpha/beta mature TCR complexes in peripheral T-cells.
PKD2 is a common signaling target downstream of various agonist receptors in platelets and G(q)-mediated signals along with calcium and novel PKC (show PKC Antibodies) isoforms, in particular, PKCdelta (show PKCd Antibodies) activate PKD2 in platelets.
Data demonstrate that, unlike PKD1 (show PKD1 Antibodies), PKD2 catalytic activity is dispensable for normal embryogenesis.
PKD2, like PKD (show PRKD1 Antibodies), facilitates mitogenesis in 3T3 cells
The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms.
protein kinase D2
, serine/threonine-protein kinase D2-like
, autosomal dominant polycystic kidney disease type II protein
, transient receptor potential cation channel, subfamily P, member 2
, serine/threonine-protein kinase D2