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Regulatory subunit of protein phosphatase 1 (By similarity).. Additionally we are shipping Protein Phosphatase 1, Regulatory Subunit 7 Proteins (8) and many more products for this protein.
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Schizosaccharomyces pombe Polyclonal PPP1R7 Primary Antibody for IF, IP - ABIN2452121
Ohkura, Yanagida: S. pombe gene sds22+ essential for a midmitotic transition encodes a leucine-rich repeat protein that positively modulates protein phosphatase-1. in Cell 1991
Show all 3 Pubmed References
a Fra-1 (show FOSL1 Antibodies)-miR (show MLXIP Antibodies)-134 axis drives a positive feedback loop that amplifies ERK (show EPHB2 Antibodies)/JNK (show MAPK8 Antibodies) signaling and reduces chemosensitivity in ovarian cancer cells.
Mechanistically, the phosphorylation of Sds22 by PLK1 (show PLK1 Antibodies) strengthens the binding of Sds22 to PP1 (show PPA1 Antibodies) and inhibits the dephosphorylation of Thr (show TRH Antibodies)(232) of Aurora B (show AURKB Antibodies) to ensure a robust, error-free metaphase-anaphase transition.
there is a second, parallel signalling pathway which triggers the relaxation of the polar cell cortex at mid anaphase--independent of furrow formation, centrosomes and microtubules, pathway depends on PP1 (show PPA1 Antibodies) phosphatase and regulatory subunit Sds22
a model in which I3 regulates an SDS22-mediated PP1 (show PPA1 Antibodies) activation step in solution that precedes SDS22 dissociation and transfer of PP1 (show PPA1 Antibodies) to kinetochores, and which is required for PP1 (show PPA1 Antibodies) to efficiently antagonize Aurora B (show AURKB Antibodies).
It was shown that Repo-Man (show CDCA2 Antibodies) and Sds22 contribute to timely Aurora B kinase (show AURKB Antibodies) substrate dephosphorylation on anaphase chromatin.
human Sds22 is focally deleted and downregulated in multiple carcinomas, and this downregulation correlates with tumor progression, suggesting that sds22 inactivation may contribute to tumorigenesis and metastatic potential
Sds22 specifically defines protein phosphatase 1 (show PPP1CB Antibodies) function and localization in mitosis.
Sds22 and Inhibitor-3 (show PPP1R11 Antibodies) form a heterotrimeric complex with PP1 (show PPA1 Antibodies), both in cell lysates and after purification. A pool of PP1 (show PPA1 Antibodies) is complexly controlled by both Sds22 and Inhibitor-3 (show PPP1R11 Antibodies).
Regulatory subunit of protein phosphatase 1 (By similarity).
protein phosphatase 1 regulatory subunit 22
, protein phosphatase 1 regulatory subunit 7
, protein phosphatase-1 regulatory subunit 7
, protein phosphatase 1, regulatory (inhibitor) subunit 7
, protein phosphatase-1 regulatory subunit 7 alpha2
, protein phosphatase-1 regulatory subunit 7 beta1
, protein phosphatase-1 regulatory subunit 7 beta2