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PPP4R1 encodes one of several alternate regulatory subunits of serine\\/threonine protein phosphatase 4 (PP4). Additionally we are shipping Protein Phosphatase 4, Regulatory Subunit 1 Proteins (4) and many more products for this protein.
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Human Polyclonal PPP4R1 Primary Antibody for ICC, IF - ABIN4347137
Wu, Ma, Qian, Liu: PP4R1 accelerates cell growth and proliferation in HepG2 hepatocellular carcinoma. in OncoTargets and therapy 2015
Show all 2 references for ABIN4347137
PP4R1 could mediate the dephosphorylation of TRAF2 (show TRAF2 Antibodies) Ser11.
PP4R1 expression was triggered upon activation and proliferation of primary human T lymphocytes and deficiency for PP4R1 caused sustained and increased IKK (show CHUK Antibodies) activity, T cell hyperactivation, and aberrant NF-kappaB (show NFKB1 Antibodies) signaling in NF-kappaB (show NFKB1 Antibodies)-addicted T cell lymphomas
LCMT-1 (show LCMT1 Antibodies) homozygous knock-out MEFs exhibited hyperphosphorylation of HDAC3 (show HDAC3 Antibodies), a reported target of the methylation-dependent PP4R1-PP4c (show PPP4C Antibodies) complex. Collectively, our data suggest that LCMT-1 (show LCMT1 Antibodies) coordinately regulates the carboxyl methylation of PP2A (show PPP2R2B Antibodies)-related phosphatases and, consequently, their holoenzyme assembly and function.
This gene encodes one of several alternate regulatory subunits of serine/threonine protein phosphatase 4 (PP4). The protein features multiple HEAT repeats. This protein forms a complex with PP4RC. This complex may have a distinct role from other PP4 complexes, including regulation of HDAC3 (Zhang et al., PMID: 15805470). There is also a transcribed pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants.
protein phosphatase 4, regulatory subunit 1
, serine/threonine phosphatase 4
, serine/threonine-protein phosphatase 4 regulatory subunit 1