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PCDH11Y belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. Additionally we are shipping Protocadherin 11 Y-Linked Antibodies (24) and many more products for this protein.
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PCDH11Y expression was detected in the fetal neocortex, ganglionic eminences, cerebellum, and inferior olive. In the adult brain, the cerebral cortex, hippocampal formation, and cerebellum and brain stem were immunoreactive.
the PCDH11X (show PCDH11 Proteins)/Y gene pair determines cerebral asymmetry by initiating the right shift in Homo sapiens
Our data...extended the lack of association of late-onset Alzheimer's disease to common PCDH11Y variants.
The present article investigated the patterns of alternative splicing and expression of the PCDH11X (show PCDH11 Proteins)/Y genes.
A 4.8 kb cDNA was cloned from TPA (show PLAT Proteins)-resistance LNCaP prostate cancer cells. It is an unusual protocadherin family gene with 2 large overlapping ORFs encoding homologous polypeptides, one with and one without a signal sequence. [protocadherin-PC]
Findings do not support the role of PCDH11Y, or more generally of a frequent specific Y chromosome, in the susceptibility to these neuropsychiatric disorders.
Our findings suggest a novel mechanism for the progression of CaP involving expression of PCDH-PC. This novel protocadherin induces Wnt (show WNT2 Proteins) signaling, promotes malignant behavior and hormone-resistance of CaP cells.
This study provided the evidence for positive selection on Protocadherin Y gene in human lineage for schizophrenia.
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein consists of an extracellular domain containing 7 cadherin repeats, a transmembrane domain and a cytoplasmic tail that differs from those of the classical cadherins. The gene is located in a major X/Y block of homology and its most closely related cadherin superfamily member is located in this homologous region on the X chromosome. The protein is thought to play a fundamental role in cell-cell recognition essential for the segmental development and function of the central nervous system. Transcripts arising from alternative splicing encode isoforms with N- and C-terminal variation.
protocadherin 11 X-linked
, protocadherin 11 Y-linked
, protocadherin 22
, protocadherin on the Y chromosome
, protocadherin prostate cancer
, protocadherin-11 Y-linked