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PCDH17 belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. Additionally we are shipping PCDH17 Antibodies (54) and many more products for this protein.
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PCDH17 methylation in serum is a frequent event in early-stage prostate cancer, and it is an independent predictor of BCR (show BCR Proteins) after radical prostatectomy
PCDH17 methylation occurred more frequently and was associated with malignant clinicopathological characteristics and poor prognosis in clear cell renal cell carcinoma (show MOK Proteins) patients
PCDH17 promoter methylation is closely associated with bladder cancer malignancy and may be used as an independent predictor of clinical outcomes in patients with bladder cancer.
PCDH17 promoter methylation was significantly associated with malignant behaviour and poor prognosis of bladder cancer
This study demonistrated that critical role for PCDH17 in the synaptic development of specific corticobasal ganglia circuits and suggest the involvement of PCDH17 in such circuits in depressive behaviors.
PCDH17 acts as a tumour suppressor, exerting its anti-proliferative activity through inducing apoptosis and autophagy, and is frequently silenced in gastric and colorectal cancers.
Our study clearly demonstrates that PCDH17 is transcriptionally downregulated in gastric cancer due to aberrant promoter CpG island methylation
statistical significant downregulation of PCDH17/PCH68 and PTPRD (show PTPRD Proteins) was observed
results suggest that silencing of PCDH17 expression through hypermethylation of the promoter or other mechanisms leads to loss of its tumour-suppressive activity, which may be a factor in the carcinogenesis of a subgroup of ESCCs
Azoospermic testis showed down-regulation of CDH18 (show CDH18 Proteins) and PCDH17.
Pcdh17 recruits the WAVE complex, Lamellipodin, and Ena/VASP (show VASP Proteins) to cell-cell contacts, converting these sites into motile structures.
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The encoded protein contains six extracellular cadherin domains, a transmembrane domain, and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein may play a role in the establishment and function of specific cell-cell connections in the brain.