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Protoporphyrinogen Oxidase Proteins (PPOX)

PPOX encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Additionally we are shipping Protoporphyrinogen Oxidase Antibodies (52) and Protoporphyrinogen Oxidase Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
PPOX 15171 O55241
PPOX 5498 P50336
Rat PPOX PPOX 289219  
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Top Protoporphyrinogen Oxidase Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Macaca fascicularis His tag   1 mg Log in to see 56 to 66 Days
$3,345.83
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

PPOX Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

More Proteins for Protoporphyrinogen Oxidase (PPOX) Interaction Partners

Mouse (Murine) Protoporphyrinogen Oxidase (PPOX) interaction partners

  1. Awake dynamics and brain-wide direct inputs of hypothalamic MCH and orexin/hypocretin networks have been discovered.

  2. Histamine Transmission Modulates the Phenotype of Murine Narcolepsy Caused by Orexin Neuron Deficiency

  3. observation that inhibition of the Orexin-1 receptor signaling blunted binge-like Ethanol, and saccharin drinking suggests that reward-related Orexin circuits participate in the consumption of salient reinforcers regardless of calories.

  4. Results suggest that exercise produces antidepressant effects via suppression of Hcrt/Orx and melanin-concentrating hormone (show PMCH Proteins) neural systems in the basolateral amygdala

  5. Hcrt neuronal activity and Hcrt-mediated stress responses were inhibited by the satiety hormone leptin (show LEP Proteins).

  6. This study demonstrated that the GABAergic input property of orexin neurons responds rapidly to sleep deprivation.

  7. sleep deprivation or increasing wakefulness by rescue of orexinergic neurons in APP/PS1 mice lacking orexin increased the amount of amyloid beta pathology in the brain.

  8. orexin activates the mTOR (show FRAP1 Proteins) pathway, a central regulator of cell growth and metabolism, in the mouse brain and cell lines that express GPCRs, OX1R (show HCRTR1 Proteins), or OX2R (show CD200R1 Proteins)

  9. This study demonistrated that absence of the Hcrt peptide has gender-specific effects. In contrast, Hcrt-ataxin mice and human narcoleptics, with loss of the whole Hcrt cell, show weight gain in both sexes.

  10. These results suggest that orexin neuronal activity plays a crucial role in the maintenance of wakefulness especially in the active phase in mice.

Human Protoporphyrinogen Oxidase (PPOX) interaction partners

  1. GAPDH (show GAPDH Proteins) and protoporphyrinogen oxidase were shown to have higher expression in faster growing cell lines and primary tumors. Pharmacologic inhibition of GAPDH (show GAPDH Proteins) or PPOX reduced the growth of colon cancer cells in vitro

  2. Variegate porphyria is the result of decreased protoporphyrinogen oxidase activity. Diet supplementation with vitamins E and C restores PPOX gene expression in lymphocytes of variegate porphyria patients.

  3. in the hepatic cancer tissue of two acute porphyria patients, somatic second-hit mutations result in nearly complete inactivation of PPOX and HMBS (show HMBS Proteins)

  4. The c.851G>T and the c.1013C>G of PPOX gene were found in two and four unrelated families respectively. 1 experienced only photosensitivity, 1 only neurological symptoms and the 2 both clinical manifestations.

  5. The mutation 1082-1083insC(1 base pair insertion at position 1082) in exon 10 of the PPOX gene was prevalent in the Swiss population.

  6. findings emphasize the usefulness of MLPA analysis as a complement to PPOX gene sequencing analysis for comprehensive genetic diagnostics in patients with variegate prophyria

  7. Information required for targeting to the mitochondria is contained within the first 250 amino acid residues of human PPOX.

  8. Modulation of penetrance by the wild-type allele in dominantly inherited erythrohepatic and acute hepatic porphyrias was studied using PPOX.

  9. Protoporphyrinogen oxidase targeting mechanism to the mitochondrion.

  10. Mutation in protoporphyrinogen oxidase is associated with variegate porphyria

Arabidopsis thaliana Protoporphyrinogen Oxidase (PPOX) interaction partners

  1. The tetrapyrrole biosynthetic enzyme PPO1 is required for plastid RNA editing.

Protoporphyrinogen Oxidase (PPOX) Protein Profile

Protein Summary

This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified.

Gene names and symbols associated with PPOX

  • Protoporphyrinogen oxidase (Ppox)
  • protoporphyrinogen oxidase (ppox)
  • protoporphyrinogen oxidase (hemY)
  • protoporphyrinogen oxidase (Mrub_1406)
  • protoporphyrinogen oxidase (Mesil_2992)
  • protoporphyrinogen oxidase (Trad_0583)
  • protoporphyrinogen oxidase (Calni_0746)
  • protoporphyrinogen oxidase (Ocepr_1049)
  • protoporphyrinogen oxidase (Tmar_0766)
  • protoporphyrinogen oxidase (Intca_1907)
  • protoporphyrinogen oxidase (Despr_0642)
  • protoporphyrinogen oxidase (Plabr_2407)
  • protoporphyrinogen oxidase (Deipr_2130)
  • protoporphyrinogen oxidase (Hipma_0622)
  • hypocretin (Hcrt)
  • protoporphyrinogen oxidase (Ppox)
  • protoporphyrinogen oxidase (PPOX)
  • BcDNA:LD41392 protein
  • CG5796 protein
  • Dmel\\CG5796 protein
  • ESTS:9F2T protein
  • hemG protein
  • HEMG1 protein
  • Ppo protein
  • PPO1 protein
  • PPOX protein
  • PROTOPORPHYRINOGEN OXIDASE protein
  • TC0121 protein
  • V290M protein
  • VP protein
  • zgc:123252 protein

Protein level used designations for PPOX

protoporphyrinogen oxidase , CG5796-PA , Ppox-PA , protoporphyrinogen-oxidase , mno , montalcino , ppo , orexin , orexin A , orexin B , prepro-orexin , protoporhyrinogen oxidase

GENE ID SPECIES
42939 Drosophila melanogaster
664750 Danio rerio
887711 Mycobacterium tuberculosis H37Rv
894184 Bacillus halodurans C-125
910131 Mycobacterium leprae TN
1017310 Oceanobacillus iheyensis HTE831
1121814 Staphylococcus aureus subsp. aureus Mu50
1245655 Chlamydia muridarum Nigg
2860707 Staphylococcus aureus subsp. aureus MRSA252
3204574 Bacillus clausii KSM-K16
3958489 Chlamydophila felis Fe/C-56
5331016 Staphylococcus aureus subsp. aureus str. Newman
5560658 Staphylococcus aureus subsp. aureus Mu3
6226299 Mycobacterium marinum M
7324674 Mycobacterium leprae Br4923
7550597 Staphylococcus carnosus subsp. carnosus TM300
8767366 Bacillus pseudofirmus OF4
8879503 Meiothermus ruber DSM 1279
9252515 Meiothermus silvanus DSM 9946
9279560 Truepera radiovictrix DSM 17093
10008757 Calditerrivibrio nitroreducens DSM 19672
10015901 Oceanithermus profundus DSM 14977
10081140 Thermaerobacter marianensis DSM 12885
10084727 Intrasporangium calvum DSM 43043
10173352 Desulfobulbus propionicus DSM 2032
10239818 Planctomyces brasiliensis DSM 5305
10265450 Deinococcus proteolyticus MRP
10391952 Hippea maritima DSM 10411
15171 Mus musculus
19044 Mus musculus
5498 Homo sapiens
478980 Canis lupus familiaris
515770 Bos taurus
289219 Rattus norvegicus
100153636 Sus scrofa
100340158 Oryctolagus cuniculus
827991 Arabidopsis thaliana
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