Purinergic Receptor P2Y, G-Protein Coupled, 12 (P2RY12) ELISA Kits

The product of P2RY12 belongs to the family of G-protein coupled receptors. Additionally we are shipping P2RY12 Antibodies (30) and P2RY12 Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
P2RY12 70839 Q9CPV9
P2RY12 64805 Q9H244
P2RY12 64803 Q9EPX4
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Top P2RY12 ELISA Kits at antibodies-online.com

Showing 10 out of 22 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human 0.057 ng/mL 0.15-10 ng/mL 96 Tests Log in to see 13 to 16 Days
Rat 0.1 ng/mL 10-250 ng/mL   96 Tests Log in to see 15 to 18 Days
  96 Tests Log in to see 15 to 18 Days
  96 Tests Log in to see 15 to 18 Days
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Guinea Pig
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More ELISA Kits for P2RY12 Interaction Partners

Mouse (Murine) Purinergic Receptor P2Y, G-Protein Coupled, 12 (P2RY12) interaction partners

  1. Vessel wall P2Y12 receptor, which promotes VSMCs migration through cofilin (show CFL1 ELISA Kits) dephosphorylation, plays a critical role in the development of atherosclerotic lesions.

  2. P2Y12 null mice are refractory to sepsis-induced lung injury, suggesting a key role for activated platelets and the P2Y12 receptor during sepsis.

  3. excessive mechanical stress may induce a sustained release of ADP and promote SMC senescence via P2ry12-dependent sustained Ras activation, thereby contributing to excessive inflammation and degeneration, which provides insights into TAAD formation and progression.

  4. AHR (show AHR ELISA Kits) and airway inflammation in a mouse model of asthma. P2Y12 can be a novel therapeutic target to the suppression of eosinophils in asthma.

  5. quinine/bupivacaine-sensitive potassium channels are the functional effectors of the P2Y12R-mediated signaling in microglia activation following neuronal injury

  6. Disrupting P2Y12 alters the microglial response to monocular deprivation and abrogates ocular dominance plasticity.

  7. P2RY12-mediated activation of juxtavascular microglial cells contributes to the rapid closure of small openings in the BBB (show ALMS1 ELISA Kits).

  8. study reports robust involvement of P2Y12R in inflammatory pain: anti-hyperalgesic effect of P2Y12R antagonism could be mediated by the inhibition of both central and peripheral cytokine production and involves alpha7-receptor mediated efferent pathways

  9. demonstrating that these P2Y12 inhibitors may not be effective in preventing early disease

  10. indicate that P2Y12R undergoes slow desensitization; ADP-P2Y12 signaling is tightly regulated by Entpd1 (show ENTPD1 ELISA Kits)/Nt5e (show NT5E ELISA Kits) activity and adenosine receptors

Human Purinergic Receptor P2Y, G-Protein Coupled, 12 (P2RY12) interaction partners

  1. Abnormalities of P2Y12 receptor include congenital deficiencies or high activity in diseases like diabetes mellitus and chronic kidney disease, exposing such patients to a prothrombotic condition. (Review)

  2. Data suggest that PAR4 (show PAWR ELISA Kits) and P2Y12 heterodimer internalization/endocytosis is required for beta-arrestin-2 (show ARRB2 ELISA Kits) recruitment to endosomes and up-regulation of Akt (show AKT1 ELISA Kits) signaling; activation of PAR4 (show PAWR ELISA Kits) but not of P2Y12 drives internalization of the PAR4 (show PAWR ELISA Kits)-P2Y12 heterodimer. (PAR4 (show PAWR ELISA Kits) = protease-activated receptor 4 (show F2RL3 ELISA Kits); P2Y12 = purinergic receptor P2Y (show P2RY1 ELISA Kits), G-protein coupled, 12 protein; Akt (show AKT1 ELISA Kits) = proto-oncogene (show RAB1A ELISA Kits) protein c (show PROC ELISA Kits)-akt (show AKT1 ELISA Kits))

  3. Studies indicate that purinergic receptor P2Y12 (P2Y12 receptor) gene C34T and G52T polymorphism might be a risk factor for the poor response to the platelet in patients on clopidogrel therapy.

  4. studies describe 2 novel modes of action of ticagrelor, inhibition of platelet ENT1 and inverse agonism at the P2Y12R that contribute to its effective inhibition of platelet activation.

  5. apart from the established association of the CYP2C19 (show CYP2C19 ELISA Kits) *2 and *3 LOF alleles with high on-treatment platelet reactivity (HTPR), haplotypes of P2RY12 rs6798347, rs6787801, rs6801273, and rs6785930 rather than rs2046934 (T744C) that related to pharmacodynamics of clopidogrel in patients with ACS (show PLA2G15 ELISA Kits) were independently associated with HTPR

  6. The present report illustrates an update of dysfunctional platelet P2Y12R mutations diagnosed with congenital lifelong bleeding problems. [review]

  7. aim of this study was to evaluate the effects of platelet receptor gene (P2Y12, P2Y1 (show P2RY1 ELISA Kits)) and glycoprotein gene (GPIIIa (show ITGB3 ELISA Kits)) polymorphisms, as well as their interactions, on antiplatelet drug responsiveness and clinical outcomes in patients with acute MIS (show AMH ELISA Kits)

  8. The Conundrum of Platelet P2Y12 Inhibition in ST-Segment Elevation Myocardial Infarction.

  9. P2Y12R gene rs2046934 C>T and rs3732759 A>G polymorphisms might be associated with the risk of coronary artery disease and the efficacy of clopidogrel treatment for CAD (show CAD ELISA Kits).

  10. No association was found in genotype frequencies of P2Y12 and responsiveness to clopidogrel in coronary heart disease patients of Han ethnicity.

P2RY12 Antigen Profile

Antigen Summary

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is involved in platelets aggregation, and is a potential target for the treatment of thromboembolisms and other clotting disorders. Two transcript variants encoding the same isoform have been identified for this gene.

Gene names and symbols associated with P2RY12

  • purinergic receptor P2Y, G-protein coupled 12 (P2ry12) antibody
  • purinergic receptor P2Y, G-protein coupled, 12 (P2RY12) antibody
  • purinergic receptor P2Y, G-protein coupled, 12 (P2ry12) antibody
  • 2900079B22Rik antibody
  • 4921504D23Rik antibody
  • ADPG-R antibody
  • BDPLT8 antibody
  • HORK3 antibody
  • P2T(AC) antibody
  • P2Y(12)R antibody
  • P2Y(AC) antibody
  • P2Y(ADP) antibody
  • P2Y(cyc) antibody
  • P2y12 antibody
  • SP1999 antibody

Protein level used designations for P2RY12

P2Y purinoceptor 12 , ADP-glucose receptor , G-protein coupled receptor SP1999 , Gi-coupled ADP receptor HORK3 , P2Y12 platelet ADP receptor , purinergic receptor P2RY12 , putative G-protein coupled receptor

70839 Mus musculus
64805 Homo sapiens
64803 Rattus norvegicus
442958 Canis lupus familiaris
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