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Pyridoxal 5-prime-phosphate (PLP) is the active form of vitamin B6 that acts as a coenzyme in maintaining biochemical homeostasis. Additionally we are shipping PDXP Antibodies (24) and PDXP Kits (19) and many more products for this protein.
Showing 9 out of 11 products:
Chronophin has a role in coordinating cell leading edge dynamics by controlling active cofilin (show CFL1 Proteins) levels
Splicing of SH3BP1 (show SH3BP1 Proteins) and CIN gene loci produces the novel brain specific (show CALY Proteins) splice variant BGIN.
analysis of pyridoxal phosphatase cloning, expression and tissue distribution
We report the biochemical isolation of chronophin (CIN), a unique cofilin (show CFL1 Proteins)-activating phosphatase of the haloacid dehalogenase (HAD) superfamily and an important novel regulator of cofilin (show CFL1 Proteins)-mediated actin reorganization.
Results suggest that the transduction of the PEP-1-PLPP fusion protein can be one mode of PLP (show PLP1 Proteins) level regulation, and to replenish this enzyme in the various neurological disorders related to vitamin B(6).
Study demonstrates the ATP-sensitive interaction of the cofilin (show CFL1 Proteins) phosphatase chronophin (CIN) with the chaperone hsp90 (show HSP90 Proteins) to form a biosensor that mediates cofilin (show CFL1 Proteins)/actin rod formation.
Evolutionary and structural analyses of mammalian haloacid dehalogenase-type phosphatases AUM and chronophin provide insight into the basis of their different substrate specificities.
Dimer formation is essential for an intermolecular arginine-arginine-tryptophan stacking interaction that positions a critical histidine residue in the substrate specificity loop of chronophin for PLP (show C3 Proteins) coordination.
Pyridoxal 5-prime-phosphate (PLP) is the active form of vitamin B6 that acts as a coenzyme in maintaining biochemical homeostasis. The preferred degradation route from PLP to 4-pyridoxic acid involves the dephosphorylation of PLP by PDXP (Jang et al., 2003
, pyridoxal phosphate phosphatase
, pyridoxal phosphatase
, reg I binding protein I
, reg I-binding protein 1