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The protein encoded by PDXK phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. Additionally we are shipping Pyridoxal Kinase Antibodies (84) and Pyridoxal Kinase Kits (23) and many more products for this protein.
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Human PDXK Protein expressed in Escherichia coli (E. coli) - ABIN667835
Hanna, Turner, Kirkness: Human pyridoxal kinase. cDNA cloning, expression, and modulation by ligands of the benzodiazepine receptor. in The Journal of biological chemistry 1997
Show all 2 references for ABIN667835
Data suggest that molting hormone (beta-ecdysterone) stimulates expression of genes coding for pyridoxal kinase (Pdxk) and pyridoxine 5'-phosphate oxidase (Pnpo (show PNPO Proteins)) in silk gland and fat body of Bombyx mori larva; juvenile hormone III appears to work against molting hormone.
direct evidence that residue Trp (show TBPL1 Proteins)(230) is crucial to maintain the structural and functional integrity of Bombyx mori pyridoxal kinase
This article describes how a cDNA encoding PLK was cloned from Bombyx mori.
The pyridoxal kinase showed decreased levels and was highly carbonylated in the gene-on mice
This study identified a DNA variant (rs2010795) in PDXK associated with an increased risk of PD in the German cohort This association was confirmed in the British and Italian cohorts individually and reached a combined value.
Pyridoxal kinase expression was compared in fetal Down syndrome (DS) brain and controls; PDXK levels were found to be similar.
The crystal structure of the MgATP complex also reveals Mg(2 (show MUC7 Proteins)+) and Na(+) acting in tandem to anchor the ATP at the active site of pyridoxal kinase.
It appears that specific interactions occur between PK and pyridoxal-5-phosphate-dependent enzymes, and the binding affinities of PK for PLP (show PLP1 Proteins)-dependent enzymes decrease in the presence of PLP (show PLP1 Proteins)
The phenotype, stress responses, vitamer levels, and regulation of the vitamin B6 pathway genes in Arabidopsis plants mutant in pyridoxine/pyridoxamine 5'-phosphate oxidase (show PNPO Proteins) (PDX3) and SALT OVERLY SENSITIVE4 (SOS4) are reported.
The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
, Pyridoxal kinase
, hypothetical protein
, pyridoxamine kinase
, pyridoxine kinase
, vitamin B6 kinase
, pyridoxal kinase (pyridoxine kinase)