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The protein encoded by RAB18 is a member of a family of Ras-related small GTPases that regulate membrane trafficking in organelles and transport vesicles. Additionally we are shipping RAB18, Member RAS Oncogene Family Proteins (12) and RAB18, Member RAS Oncogene Family Kits (7) and many more products for this protein.
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Chicken Polyclonal RAB18 Primary Antibody for WB - ABIN2777760
Ohsaki, Maeda, Maeda, Tauchi-Sato, Fujimoto: Recruitment of TIP47 to lipid droplets is controlled by the putative hydrophobic cleft. in Biochemical and biophysical research communications 2006
Warburg Micro syndrome is caused by RAB18 deficiency.
findings suggest that RAB18 rs3765133 polymorphism affects the development of specific brain regions, particularly the cerebellum, in healthy people
These results suggest that Rab18 has an important role in viral assembly through the trafficking of the hepatitis C virus core protein to lipid droplets.
High RAB18 expression is associated with glioma.
Rab18-mediated membrane trafficking of FASN (show FASN Antibodies) and NS3 facilitates dengue virus replication.
Rab18 and a Rab18 GEF (show SLC2A4RG Antibodies) complex of Rab3GAP1 (show RAB3GAP1 Antibodies) and Rab3GAP2 (show RAB3GAP2 Antibodies) have roles in the endoplasmic reticulum structure
Rab18 interacts with the HCV nonstructural protein NS5A.
One-hundred and forty-four Micro and nine Martsolf families were investigated, identifying mutations in RAB3GAP1 (show RAB3GAP1 Antibodies) in 41% of cases, mutations in RAB3GAP2 (show RAB3GAP2 Antibodies) in 7% of cases, and mutations in RAB18 in 5% of cases
Hepatitis B virus X protein enhances proliferation of hepatoma cells through Rab18.
Micro syndrome has been associated with causative mutations in three disease genes: RAB3GAP1 (show RAB3GAP1 Antibodies), RAB3GAP2 (show RAB3GAP2 Antibodies) and RAB18. Martsolf syndrome has been associated with a mutation in RAB3GAP2 (show RAB3GAP2 Antibodies). [Review]
Retinoid and cholesterol metabolism are linked in stellate cells by the LD-associated protein Rab18 and may have significant therapeutic benefit in liver fibrosis.
The results of this study indicated that the sensory nervous system is more vulnerable to Rab18 deficiency and WARBM is not only a neurodevelopmental but also neurodegenerative disease.
apparent similarities between the WARBM phenotype and the phenotype that we describe here indicate that the Rab18-mutant mouse provides an important platform for investigation of the disease pathogenesis and therapeutic interventions
Data suggest that overexpression of Rab18 in its GDP-bound state favors peroxisome proliferation in hepatocytes; Rab18 (as well as Rab6 (show RAB6A Antibodies), Rab10 (show RAB10 Antibodies), and Rab14 (show RAB14 Antibodies)) localizes to the peroxisomal compartment.
Rab18 regulates lipid droplet-associated membrane formation
results show that a Rab (show HRB Antibodies) protein localizes directly to the monolayer surface of lipid droplets
in neuroendocrine cells, Rab18 acts as a negative regulator of secretory activity, likely by impairing secretory granule transport
The protein encoded by this gene is a member of a family of Ras-related small GTPases that regulate membrane trafficking in organelles and transport vesicles. Knockdown studies is zebrafish suggest that this protein may have a role in eye and brain development. Mutations in this gene are associated with Warburg micro syndrome type 3. Alternatively spliced transcript variants have been found for this gene.
RAB18, member RAS oncogene family
, RAB18 small GTPase
, Ras-related protein Rab-18
, ras-related protein Rab-18
, GTP-binding protein Rab18