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RAB21 belongs to the RAB family of small GTP-binding proteins that regulate intracellular vesicle targeting (Opdam et al., 2000 [PubMed 10887961]).[supplied by OMIM, Nov 2008].. Additionally we are shipping RAB21 Antibodies (67) and many more products for this protein.
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Human RAB21 Protein expressed in Escherichia coli (E. coli) - ABIN667873
Pellinen, Tuomi, Arjonen, Wolf, Edgren, Meyer, Grosse, Kitzing, Rantala, Kallioniemi, Fässler, Kallio, Ivaska: Integrin trafficking regulated by Rab21 is necessary for cytokinesis. in Developmental cell 2008
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Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 (show VAMP8 Proteins) to promote autophagosome-lysosome fusion.
High RAB21 expression is associated with glioma.
Taken together, these data suggest that Rab21 plays a negative role in the EGF (show EGF Proteins)-mediated MAPK (show MAPK1 Proteins) signaling pathway. Overexpression of Rab21 attenuated EGF (show EGF Proteins)-mediated mitogen-activated protein kinase (show MAPK1 Proteins) (MAPK (show MAPK1 Proteins)) signaling by inducing EGFR (show EGFR Proteins) degradation.
Rab21 (and Rab5 (show RAB5A Proteins)) associate with the cytoplasmic domains of alpha-integrin chains, and their expression influences the endo/exocytic traffic of integrins. This function of Rab21 is dependent on its GTP (show AK3 Proteins)/GDP cycle and proper membrane targeting
Results show that targeted trafficking of integrins to and from the cleavage furrow is required for successful cytokinesis, and that this is regulated by Rab21.
show that TI-VAMP (show VAMP7 Proteins) interacts with the Vps9 domain and ankyrin-repeat-containing protein Varp (show ANKRD27 Proteins), a guanine nucleotide exchange factor (show RASGRF1 Proteins) of the small GTPase (show RACGAP1 Proteins) Rab21, through a specific domain herein called the interacting domain.
this novel finding that Rab21 regulates SSTR3 (show SSTR3 Proteins) trafficking suggests that Rab21 may play a role in trafficking of other GPCRs.
Mechanistically, p120RasGAP (show RASA1 Proteins) interacted with the cytoplasmic domain of integrin alpha-subunits via its GAP domain and competed with Rab21 for binding to endocytosed integrins.
data indicate that Rab21 is a transient component of early and intermediate stages of macropinocytosis, and probably functions in macropinosome maturation before fusing with lysosomal compartments
RAB21 belongs to the RAB family of small GTP-binding proteins that regulate intracellular vesicle targeting (Opdam et al., 2000
ras-related protein Rab-21
, RAB21, member RAS oncogene family