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RAB27A, Member RAS Oncogene Family Proteins (RAB27A)

The protein encoded by RAB27A belongs to the small GTPase superfamily, Rab family. Additionally we are shipping RAB27A Antibodies (78) and RAB27A Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RAB27A 5873 P51159
RAB27A 11891 Q9ERI2
RAB27A 50645 P23640
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Top RAB27A Proteins at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$286.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,552.00
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,552.00
Details
Yeast Dog His tag   1 mg Log in to see 56 to 66 Days
$2,552.00
Details
HOST_Escherichia coli (E. coli) Human His tag   1 mg Log in to see 3 to 4 Days
$2,524.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$322.14
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

RAB27A Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced RAB27A Proteins

  1. Human RAB27A Protein expressed in Escherichia coli (E. coli) - ABIN666995 : Kuroda, Fukuda, Ariga, Mikoshiba: The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain. in The Journal of biological chemistry 2002 (PubMed)

More Proteins for RAB27A, Member RAS Oncogene Family (RAB27A) Interaction Partners

Human RAB27A, Member RAS Oncogene Family (RAB27A) interaction partners

  1. decreased expression of Rab27A and Rab27B (show RAB27B Proteins), especially Rab27A, closely correlated with tumor progression and are valuable prognostic indicators in colorectal cancer patients.

  2. We report two unrelated teenagers with hemophagocytic lymphohistiocytosis and an identical heterozygous RAB27A mutation (c.259G-->C).

  3. Data suggest that microRNA miR (show MLXIP Proteins)-582-5p may function as a tumor suppressor in the development of colorectal carcinoma (CRC (show CALR Proteins)) by targeting RAS-related GTP-binding protein (show RAB10 Proteins) (Rab27a), indicating a novel therapeutic strategy for patients with CRC (show CALR Proteins).

  4. Experimental data are reviewed with a focus on the secretory Rab27 family of small GTPases and their implications in cancer progression.

  5. miR (show MLXIP Proteins)-122 has a Rab27a-dependent function in the hepatitis C virus lifecycle

  6. Rab27A may be used as a valuable prognostic biomarker for colorectal carcinoma patients.

  7. Our data indicate that RAB27A expression is an independent prognostic marker for pancreatic ductal adenocarcinoma

  8. This study identified a common variant located in RAB27A gene influencing FeNO levels specifically in adults and with a biological relevance to the regulation of FeNO levels.

  9. These studies highlight the need for RAB27A sequencing in patients with FHL (show FHL1 Proteins) with normal pigmentation and identify a critical binding site for Munc13-4 (show UNC13D Proteins) on Rab27a, revealing the molecular basis of this interaction.

  10. Data show that cystic fibrosis (show S100A8 Proteins) (CF) neutrophils release less secondary and tertiary granule components and that activation of the low-molecular-mass GTP-binding protein Rab27a, involved in the regulation of granule trafficking, is defective.

Mouse (Murine) RAB27A, Member RAS Oncogene Family (RAB27A) interaction partners

  1. Given that GTP (show AK3 Proteins)- and GDP-bound Rab27a regulate exocytosis.

  2. This paper showed an inhibitory effect of Rab27a directly at the pore forming CaV1.3 (show CACNA1D Proteins) subunit of L-type channels, leading to decreased current density and reduced VEGF-A (show VEGFA Proteins) secretion by the retinal pigment epithelium.

  3. results show that Rab27A is present in mouse pancreatic acinar cells and mainly regulates secretion through the minor-regulated pathway

  4. Rab27A deficiency shows the increased surface level of c-fms (show CSF1R Proteins), and the delayed downregulation of RANK in ashen cells, resulting in enhanced signaling of M-CSF (show CSF1R Proteins) and RANKL (show TNFSF11 Proteins).

  5. Rab27b (show RAB27B Proteins) is expressed in bone marrow derived neutrophils and Rab27b (show RAB27B Proteins) knockout (Rab27b (show RAB27B Proteins) KO) along with Rab27a/b double knockout (Rab27DKO) neutrophils exhibit impaired transwell migration in vitro in response to chemokines MIP-2 (show CXCL2 Proteins) and LTB4 (show PTGR1 Proteins).

  6. Our findings indicate that Slp2-a (show SYTL2 Proteins) controls renal cell size through regulation of Rap (show LRPAP1 Proteins)-ezrin (show EZR Proteins) signaling independently of Rab27.

  7. The results showed that Rab27A(Q78L) is unable to localize on mature melanosomes and that its inhibitory activity on melanosome transport is completely dependent on its binding to the Rab27A effector Slac2-a/melanophilin (show MLPH Proteins).

  8. Rab27a has a key role in eosinophil degranulation. Furthermore, these findings have implications for Rab27a-dependent eosinophil degranulation in airway inflammation.

  9. Upregulation of the Rab27a-dependent lysosomal trafficking and secretory pathways contributes to the correction of some of the cellular defects induced by lysosomal overload in cystinosis, including endoplasmic reticulum stress.

  10. Data suggest that Rab27a and Rab27b (show RAB27B Proteins) regulate distinct steps in the bone marrow-derived mast cells (BMMC) degranulation pathway, with Rab27a/Mlph (show MLPH Proteins)/MyoVa (show MYO5A Proteins) regulating cortical actin stability upstream of Rab27a/b/Munc13-4 (show UNC13D Proteins)-dependent granule exocytosis.

RAB27A Protein Profile

Protein Summary

The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. The protein is membrane-bound and may be involved in protein transport and small GTPase mediated signal transduction. Mutations in this gene are associated with Griscelli syndrome type 2. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.

Gene names and symbols associated with RAB27A

  • RAB27A, member RAS oncogene family (rab27a)
  • RAB27A, member RAS oncogene family (RAB27A)
  • RAB27A, member RAS oncogene family (rab27a-b)
  • RAB27A, member RAS oncogene family (Rab27a)
  • 2210402C08Rik protein
  • 2410003M20Rik protein
  • 4933437C11Rik protein
  • ash protein
  • GS2 protein
  • HsT18676 protein
  • MGC80943 protein
  • MGC89827 protein
  • RAB27 protein
  • RAB27A protein
  • RAM protein
  • zgc:114135 protein

Protein level used designations for RAB27A

RAB27A, member RAS oncogene family , Ras-related protein Rab-27A , rab27a, member ras oncogene family , ras-related protein Rab-27A , GTP-binding protein Ram , rab-27 , member RAS oncogene family, RAB27A , ashen , low Mr GTP-binding protein , ram p25 , RAS oncogene family member

GENE ID SPECIES
444290 Xenopus laevis
453455 Pan troglodytes
493339 Xenopus (Silurana) tropicalis
494641 Xenopus laevis
570907 Danio rerio
5873 Homo sapiens
606749 Sus scrofa
618035 Bos taurus
11891 Mus musculus
50645 Rattus norvegicus
608699 Canis lupus familiaris
415410 Gallus gallus
101086976 Felis catus
101122791 Ovis aries
100720981 Cavia porcellus
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