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RAB4A is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. Additionally we are shipping RAB4A, Member RAS Oncogene Family Antibodies (86) and many more products for this protein.
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Human RAB4A Protein expressed in Escherichia coli (E. coli) - ABIN667483
Li, Omata, Kojima, Shibata: Direct interaction of Rab4 with syntaxin 4. in The Journal of biological chemistry 2001
Show all 2 references for ABIN667483
The results contradict the model of feedback activation of Rab5 (show RAB5A Proteins) and instead indicate that Rbpt5 is recruited by both Rabex5 (show RABGEF1 Proteins) recognizing ubiquitylated cargo and by Rab4 to activate Rab5 (show RAB5A Proteins) in a feed-forward manner.
Rab4 expression is up-regulated by laminar shear stress, which contributed to improved vascular endothelial cell autophagy and function.
Together the findings indicate that Arl1 links Rab4-dependent formation of endosomal sorting domains with downstream assembly of adaptor protein complexes that constitute the endosomal sorting machinery.
HRES-1/Rab4 regulates autophagy through promoting the formation of LC3 (show MAP1LC3A Proteins)(+) autophagosomes and the preservation of mitochondria.
Data indicate that Rab4 regulates ether-a-go-go-related (show KCNH2 Proteins) gene (hERG (show KCNH2 Proteins)) channel density via neural precursor cell-expressed developmentally down-regulated protein 4 (show NEDD4 Proteins)-2 (Nedd4-2 (show NEDD4L Proteins)).
our findings suggest an evolutionarily conserved function of HDPTP-Rab4 in the regulation of endocytic trafficking, cell adhesion and migration.
TBC1D16 (show TBC1D16 Proteins) is a GTPase activating protein (show RASA1 Proteins) for Rab4A that regulates transferrin receptor recycling and EGFR (show EGFR Proteins) trafficking and signaling.
Upregulated expression of rab4, rab5 (show RAB5A Proteins), rab7 (show RAB7B Proteins) and rab27 (show RAB27A Proteins) correlates with antemortem measures of cognitive decline in individuals with mild cognitive impairment and Alzheimer disease.
Thus down- or up-regulation of Rab4A expression or Rab4A function triggered inhibition or increase of procathepsin L secretion respectively.
Overexpression of Rab4 regulates angiotensin II type I receptor phosphorylation and sensitization.
Insulin (show INS Proteins)-dependent Rab4a redistribution, probably reflecting stimulation of vesicle-mediated transport, is inhibited in adipocytes subjected to differentiation in the presence of IL-6 (show IL6 Proteins), IL-8 (show IL8 Proteins), or IL-15 (show IL15 Proteins).
Reduced Akt2 (show AKT2 Proteins) leads to up-regulation of Rab4a expression in cardiomyocytes in a cell-autonomous fashion that may involve activation of PPARalpha (show PPARA Proteins).
insulin (show INS Proteins) signaling stimulates Rab4 activity, the association of Rab4 with kinesin, the interaction of KIF3 (show KIF3A Proteins) with microtubules and this process is mediated by insulin (show INS Proteins)-induced PI3-kinase (show PIK3CA Proteins)-dependent PKC-lambda activation and participates in GLUT4 (show SLC2A4 Proteins) exocytosis
p85alpha protein may play a role in the down-regulation of activated receptors through its temporal control of the GTPase (show RACGAP1 Proteins) cycles of Rab5 (show RAB5A Proteins) and Rab4
Rab4 is a rate-limiting factor for the recycling of endogenous beta-AR; and augmentation of Rab4-mediated traffic enhances beta-AR function in cardiac myocytes
Rabip4s, possibly via their interaction with Rab4, regulate integrin trafficking and are involved in the migration of NIH 3T3 fibroblasts
Sorting of PDGF (show PDGFA Proteins) beta-receptors on early endosomes is regulated by sequential activation of PKCalpha (show PKCa Proteins) and Rab4a and that this sorting step could constitute a point of cross-talk with other receptors.
Receptor recycling is mediated by AP-1 (show JUN Proteins)/clathrin-coated vesicles and regulated by rab4 and rabaptin-5/rabex-5 (show RABGEF1 Proteins).
This gene is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and recycling. The protein also plays a role in regulating the recycling of receptors from endosomes to the plasma membrane. Alternatively spliced transcript variants have been observed for this gene.
RAB4A, member RAS oncogene family
, ras-related protein Rab-4A
, Ras-related small GTP binding protein 4