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Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum. Additionally we are shipping RINT1 Antibodies (20) and many more products for this protein.
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Results suggest that high RAD50 interactor 1 (RINT1) expression may represent a risk factor for low-grade gliomas (LGGs)-related seizures.
Results identified RINT1 as a putative breast cancer predisposition gene that also seems to be associated with risk for a spectrum of other cancers similar to those that have previously been described for Lynch syndrome.
RINT-1 is also required for endosome-to-trans-Golgi network trafficking.
RINT1 was validated as a novel glioblastoma oncogene (show RAB1A Proteins)
RINT-1 coordinates the localization and function of ZW10 (show ZW10 Proteins) by serving as a link between ZW10 (show ZW10 Proteins) and the SNARE (show NAPA Proteins) complex comprising syntaxin 18 (show STX18 Proteins).
These findings suggest that RINT-1 serves as a novel tumor suppressor essential for maintaining the dynamic integrity of the Golgi apparatus and the centrosome, a prerequisite to their proper coordination during cell division.
Rab6 (show RAB6A Proteins) regulates distinct Golgi trafficking pathways involving two separate protein complexes: ZW10 (show ZW10 Proteins)/RINT-1 and COG (show TG Proteins).
Results together suggest that NAG (show NAGLU Proteins) links between p31 (show ATP6V1E1 Proteins) and ZW10 (show ZW10 Proteins)-RINT-1 and is involved in Golgi-to-ER transport.
Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum. May play a role in cell cycle checkpoint control. Essential for telomere length control.
RAD50-interacting protein 1