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Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum. Additionally we are shipping RINT1 Antibodies (21) and many more products for this protein.
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Results suggest that high RAD50 interactor 1 (RINT1) expression may represent a risk factor for low-grade gliomas (LGGs)-related seizures.
Results identified RINT1 as a putative breast cancer predisposition gene that also seems to be associated with risk for a spectrum of other cancers similar to those that have previously been described for Lynch syndrome.
RINT-1 is also required for endosome-to-trans-Golgi network trafficking.
RINT1 was validated as a novel glioblastoma oncogene (show RAB1A Proteins)
RINT-1 coordinates the localization and function of ZW10 (show ZW10 Proteins) by serving as a link between ZW10 (show ZW10 Proteins) and the SNARE (show NAPA Proteins) complex comprising syntaxin 18 (show STX18 Proteins).
These findings suggest that RINT-1 serves as a novel tumor suppressor essential for maintaining the dynamic integrity of the Golgi apparatus and the centrosome, a prerequisite to their proper coordination during cell division.
Rab6 (show RAB6A Proteins) regulates distinct Golgi trafficking pathways involving two separate protein complexes: ZW10 (show ZW10 Proteins)/RINT-1 and COG (show TG Proteins).
Results together suggest that NAG (show NAGLU Proteins) links between p31 (show ATP6V1E1 Proteins) and ZW10 (show ZW10 Proteins)-RINT-1 and is involved in Golgi-to-ER transport.
A crucial role of Rint1 in vivo in genomic stability maintenance, as well as in prevention of endoplasmic reticulum stress and autophagy.
Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum. May play a role in cell cycle checkpoint control. Essential for telomere length control.
RAD50-interacting protein 1