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DNA helicase that modulates androgen receptor (AR)- dependent transactivation in a promoter-dependent manner. Additionally we are shipping RAD54L2 Antibodies (16) and RAD54L2 Kits (5) and many more products for this protein.
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p62 (show GTF2H1 Proteins) is a novel binding partner for ARIP4, and that its binding regulates the cellular protein level of ARIP4 under conditions of metabolic stress.
ARIP4 is an AR coregulator in Sertoli cells in vivo, but the expression in the germ cells implies that it has also AR-independent functions in spermatogenesis.
ARIP4 plays an essential role in mouse embryonic development and cell proliferation, and it appears to coordinate multiple essential biological processes, possibly through a complex chromatin remodeling system.
The ATPase activity of ARIP4 was stimulated in the presence of sumoylated Ad4BP/SF-1 (show NR5A1 Proteins) and the Ad4BP/SF-1 (show NR5A1 Proteins)-binding site containing double-stranded DNA.
DNA helicase that modulates androgen receptor (AR)- dependent transactivation in a promoter-dependent manner. Not able to remodel mononucleosomes in vitro. Acts as an AR-coregulator in Sertoli cells.
, RAD54-like protein 2
, androgen receptor-interacting protein 4
, helicase ARIP4
, steroid receptor-interacting SNF2 domain protein